Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Carmela Ciardullo"'
Autor:
Carmela Ciardullo, Erhan Aptullahoglu, Laura Woodhouse, Wei-Yu Lin, Jonathan P Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec
Publikováno v:
Haematologica, Vol 104, Iss 12 (2019)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous hematologic malignancy. In approximately 90% of cases the TP53 gene is in its wildtype state at diagnosis of this malignancy. As mouse double-minute-2 homolog (MDM2) is a primary repres
Externí odkaz:
https://doaj.org/article/7ecccf9c482b45a5821d7071778cdfac
Autor:
Silvia Rasi, Hossein Khiabanian, Carmela Ciardullo, Lodovico Terzi-di-Bergamo, Sara Monti, Valeria Spina, Alessio Bruscaggin, Michaela Cerri, Clara Deambrogi, Lavinia Martuscelli, Alessandra Biasi, Elisa Spaccarotella, Lorenzo De Paoli, Valter Gattei, Robin Foà, Raul Rabadan, Gianluca Gaidano, Davide Rossi
Publikováno v:
Haematologica, Vol 101, Iss 4 (2016)
Externí odkaz:
https://doaj.org/article/d170070b966d4797b82b81771b522525
Autor:
Nicholas Turner, Christos Vaklavas, Emiliano Calvo, Javier Garcia-Corbacho, Jason Incorvati, Manuel Ruiz Borrego, Chris Twelves, Anne Armstrong, Begoña Bermejo, Erika Hamilton, Mafalda Oliveira, Eva Ciruelos, Peter Kabos, Manish R Patel, Maria Borrell, Howard Burris, Bruno de Paula, Alejandro Falcon, Cristina Hernando, Irene Moreno, Ciara S. O’Brien, Elena Shagisultanova, Ivan Victoria Ruiz, Judy S. Wang, Mei Wei, Tim Brier, Danielle Carroll, Carmela Ciardullo, Lisa Gibbons, itziar irurzun-Arana, Tony Jack, bistra kirova, Teresa Klinowska, Justin Lindemann, Julie Maidment, Alastair Mathewson, Rhiannon Maudsley, Robert McEwen, Christopher Morrow, Andy Sykes, Richard D. Baird
Background: SERENA-1 (NCT03616587) is a Phase 1, multi-part, open-label study of camizestrant in women with ER+/HER2− advanced breast cancer. Parts A/B and C/D (escalation/expansion) examined camizestrant as monotherapy and in combination with palb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3b0f1e0fcbdd82a029a528d47540d2
https://www.repository.cam.ac.uk/handle/1810/350214
https://www.repository.cam.ac.uk/handle/1810/350214
Autor:
Erhan Aptullahoglu, Carmela Ciardullo, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2410
Volume 24
Issue 3
Pages: 2410
Several molecular subtypes of cancer are highly dependent on splicing for cell survival. There is a general interest in the therapeutic targeting of splicing by small molecules. E7107, a first-in-class spliceosome inhibitor, showed strong growth inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68f1c3a71c65e0712498fe951c28d5b
Autor:
Carmela Ciardullo, Katarzyna Szoltysek, Peixun Zhou, Monika Pietrowska, Lukasz Marczak, Elaine Willmore, Amir Enshaei, Anna Walaszczyk, Jia Yee Ho, Vikki Rand, Scott Marshall, Andrew G. Hall, Christine J. Harrison, Meera Soundararajan, Jeyanthy Eswaran
Publikováno v:
Cancers; Volume 14; Issue 1; Pages: 23
Cancers, Vol 14, Iss 23, p 23 (2022)
Cancers
Cancers, Vol 14, Iss 23, p 23 (2022)
Cancers
Simple Summary Chronic lymphocytic leukaemia (CLL) is the most frequent type of leukaemia with a highly variable presentation, clinical course, and outcome. The overall aim of our study was to determine the clinical and functional significance of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7bb282e088df208cee73fc44cb4c01
https://doi.org/10.3390/cancers14010023
https://doi.org/10.3390/cancers14010023
Autor:
Scott Marshall, Anna Walaszczyk, Carmela Ciardullo, Katarzyna Szoltysek, Andrew G. Hall, Meera Soundararajan, Elaine Willmore, Vikki Rand, P Zhou, Christine J. Harrison, Jeyanthy Eswaran
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7663, p 7663 (2020)
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7663, p 7663 (2020)
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the Western World and it is characterized by a marked degree of clinical heterogeneity. An impaired balance between pro- and anti-apoptotic stimuli determines chemorefractoriness
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4b5ce27a58d0dacef7822e49dd4df2
https://doi.org/10.3390/ijms21207663
https://doi.org/10.3390/ijms21207663
Autor:
Wei-Yu Lin, John Lunec, Laura Woodhouse, Helen Marr, Scott Marshall, Erhan Aptullahoglu, Elaine Willmore, Nick Bown, Carmela Ciardullo, Jonathan P. Wallis
Publikováno v:
Haematologica. 104(12)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous hematologic malignancy. In approximately 90% of cases the TP53 gene is in its wildtype state at diagnosis of this malignancy. As mouse double-minute-2 homolog (MDM2) is a primary repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0639c4368e5ad6464a3b8e991d2c8de6
https://pubmed.ncbi.nlm.nih.gov/31787615
https://pubmed.ncbi.nlm.nih.gov/31787615
Autor:
Fortunato Morabito, Davide Rossi, Stefano Molica, Caterina Musolino, Gabriella Ciceri, Manlio Ferrarini, Francesco Maura, Monica Colombo, Giovanna Cutrona, Carmela Ciardullo, Anna Grazia Recchia, Luca Agnelli, Gianluca Gaidano, Agostino Cortelezzi, Francesco Di Raimondo, Marta Lionetti, Serena Matis, Sonia Fabris, Laura Mosca, Massimo Gentile, Antonino Neri, Fiorella Ilariucci
Publikováno v:
British Journal of Haematology. 165:629-639
NOTCH1 mutations have recently emerged as new genetic lesions significantly correlated with survival in chronic lymphocytic leukemia (CLL). NOTCH1 c.7541_7542delCT is by far the most frequently observed NOTCH1 mutation in the disease. To estimate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7966769217cb0d2f98933a7190b8bc
https://doi.org/10.1111/bjh.12800
https://doi.org/10.1111/bjh.12800
Autor:
Lorenzo Cerroni, Laurence Mevellec, Andreas Rosenwald, Giorgio Inghirami, Luigi Barbarossa, Elena Lasorsa, Enrico Tiacci, Miguel A. Piris, Francesco Bertoni, Davide Rossi, Elisabetta Ercole, Nicoletta Chiesa, Filomena Di Giacomo, Domenico Novero, Maria Todaro, Alberto Zamò, Jorge Vialard, Ramona Crescenzo, Alexander Tzankov, Andrea Rinaldi, Lukas Kenner, Leonard D. Shultz, Francesco Abate, Thomas Tousseyn, Raul Rabadan, Javeed Iqbal, Dennis D. Weisenburger, Brunangelo Falini, Carmela Ciardullo, Elisa Ficarra, Wing C. Chan, Gianluca Gaidano, Elisa Spaccarotella, Andrea Acquaviva, Roberto Piva, Stefano Pileri, Fabrizio Tabbò, Marcello Gaudiano, Michela Boi, Marco Paulli, Maurilio Ponzoni
JAK/STAT3 signaling pathway is often deregulated in hematopoietic disorders including peripheral T-cell lymphoma. We describe two novel mechanisms leading to the constitutive activation of STAT3 in ALK- ALCL. Oncogenic JAK1 or STAT3 mutations are ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a9d987f67c88511b8a93dfda4325af
http://hdl.handle.net/11583/2598380
http://hdl.handle.net/11583/2598380
Publikováno v:
Immunology Letters. 155:51-55
The human genome era heralded a fundamental progress in the field of cancer genetics that shifted from a candidate gene approach toward global views of genomes and transcriptomes. Whole genome/exome sequencing has disclosed the genetic landscape of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed37c2ae0ed0371b4262dd934e9747a
https://doi.org/10.1016/j.imlet.2013.09.010
https://doi.org/10.1016/j.imlet.2013.09.010