Long-term effects of early antiretroviral initiation on HIV reservoir markers: a longitudinal analysis of the MERLIN clinical study

Autor: Marta Massanella, PhD, Rachel A Bender Ignacio, MD, Javier R Lama, MD, Amélie Pagliuzza, MSc, Sayan Dasgupta, PhD, Ricardo Alfaro, MS, Jessica Rios, MS, Carmela Ganoza, MD, Delia Pinto-Santini, PhD, Trupti Gilada, MD, Ann Duerr, ProfMD, Nicolas Chomont, PhD

Publikováno v: The Lancet Microbe, Vol 2, Iss 5, Pp e198-e209 (2021)

Summary: Background: Early antiretroviral therapy (ART) initiation (ie, within 3 months of infection) limits establishment of the HIV reservoir. However, the effect of early ART initiation on the long-term dynamics of the pool of infected cells remai

Externí odkaz: https://doaj.org/article/edfb4035302a4262bf5cbdd8a1fc440f

Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control.

Autor: Bruna Oriol-Tordera, Maria Berdasco, Anuska Llano, Beatriz Mothe, Cristina Gálvez, Javier Martinez-Picado, Jorge Carrillo, Julià Blanco, Clara Duran-Castells, Carmela Ganoza, Jorge Sanchez, Bonaventura Clotet, Maria Luz Calle, Alex Sánchez-Pla, Manel Esteller, Christian Brander, Marta Ruiz-Riol

Publikováno v: PLoS Pathogens, Vol 16, Iss 8, p e1008678 (2020)

GWAS, immune analyses and biomarker screenings have identified host factors associated with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms that regulate the expression of such host factors. Here, we aimed to asse

Externí odkaz: https://doaj.org/article/932994bc041b404db54d93aecb303cb6

Antiretroviral Initiation at ≥800 CD4+ Cells/mm3 Associated With Lower Human Immunodeficiency Virus Reservoir Size

Autor: Thomas A Rasmussen, Sunil K Ahuja, Locadiah Kuwanda, Michael J Vjecha, Fleur Hudson, Luxshimi Lal, Ajantha Rhodes, Judy Chang, Sarah Palmer, Paula Auberson-Munderi, Henry Mugerwa, Robin Wood, Sharlaa Badal-Faesen, Sandy Pillay, Rosie Mngqibisa, Alberto LaRosa, Jose Hildago, Kathy Petoumenos, Chris Chiu, Joseph Lutaakome, Jonathan Kitonsa, Esther Kabaswaga, Pietro Pala, Carmela Ganoza, Katie Fisher, Christina Chang, Sharon R Lewin, Edwina J Wright

Publikováno v: Rasmussen, T A, Ahuja, S K, Kuwanda, L, Vjecha, M J, Hudson, F, Lal, L, Rhodes, A, Chang, J, Palmer, S, Auberson-Munderi, P, Mugerwa, H, Wood, R, Badal-Faesen, S, Pillay, S, Mngqibisa, R, LaRosa, A, Hildago, J, Petoumenos, K, Chiu, C, Lutaakome, J, Kitonsa, J, Kabaswaga, E, Pala, P, Ganoza, C, Fisher, K, Chang, C, Lewin, S R & Wright, E J 2022, ' Antiretroviral Initiation at ≥800 CD4+ Cells/mm3 Associated With Lower Human Immunodeficiency Virus Reservoir Size ', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 75, no. 10, pp. 1781-1791 . https://doi.org/10.1093/cid/ciac249

Background Identifying factors that determine the frequency of latently infected CD4+ T cells on antiretroviral therapy (ART) may inform strategies for human immunodeficiency virus (HIV) cure. We investigated the role of CD4+ count at ART initiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f116ba0824e2958cc89046c4f89b6ea9
https://doi.org/10.1093/cid/ciac249

TL1A–DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1–Specific T Cell Responses

Autor: Beatriz Mothe, Bonaventura Clotet, Eugenia Negredo, Marta Massanella, Jorge Sanchez, Dennis J. Hartigan-O'Connor, Carmela Ganoza, Christian Brander, Marta Ruiz-Riol, Maria Luz Calle, Julià Blanco, Clara Duran-Castells, Judith Dalmau, Alex Olvera, Javier Martinez-Picado, Bruna Oriol-Tordera, Anuska Llano

Publikováno v: Journal of immunology (Baltimore, Md. : 1950), vol 205, iss 12
Journal of Immunology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
J Immunol
The Journal of Immunology

Relative control of HIV-1 infection has been linked to genetic and immune host factors. In this study, we analyzed 96 plasma proteome arrays from chronic untreated HIV-1–infected individuals using the classificatory random forest approach to discri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd6fdedc45576ea913c36834164c0b5
https://doi.org/10.4049/jimmunol.2000933

Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones

Autor: Jack A. Collora, Runxia Liu, Delia Pinto-Santini, Neal Ravindra, Carmela Ganoza, Javier R. Lama, Ricardo Alfaro, Jennifer Chiarella, Serena Spudich, Karam Mounzer, Pablo Tebas, Luis J. Montaner, David van Dijk, Ann Duerr, Ya-Chi Ho

Publikováno v: Immunity

Understanding the drivers and markers of clonally expanding HIV-1-infected CD4(+) T cells is essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface protein expression, cellular transcriptome, HIV-1 RNA, and TCR sequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5f9397094c8a423e3d1be590ef0108
https://europepmc.org/articles/PMC9203927/