Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Carmel M. O'Brien"'
Autor:
Ryan J. Farr, Nathan Godde, Christopher Cowled, Vinod Sundaramoorthy, Diane Green, Cameron Stewart, John Bingham, Carmel M. O’Brien, Megan Dearnley
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Despite being vaccine preventable, rabies (lyssavirus) still has a significant impact on global mortality, disproportionally affecting children under 15 years of age. This neurotropic virus is deft at avoiding the immune system while travelling throu
Externí odkaz:
https://doaj.org/article/b24e887c7bd34c15a221782c04d4c147
Autor:
Alexander J. McAuley, Petrus Jansen van Vuren, Muzaffar-Ur-Rehman Mohammed, Faheem, Sarah Goldie, Shane Riddell, Nathan J. Gödde, Ian K. Styles, Matthew P. Bruce, Simran Chahal, Stephanie Keating, Kim R. Blasdell, Mary Tachedjian, Carmel M. O’Brien, Nagendrakumar Balasubramanian Singanallur, John Noel Viana, Aditya V. Vashi, Carl M. Kirkpatrick, Christopher A. MacRaild, Rohan M. Shah, Elizabeth Vincan, Eugene Athan, Darren J. Creek, Natalie L. Trevaskis, Sankaranarayanan Murugesan, Anupama Kumar, Seshadri S. Vasan
Publikováno v:
Viruses, Vol 14, Iss 11, p 2417 (2022)
The repurposing of licenced drugs for use against COVID-19 is one of the most rapid ways to develop new and alternative therapeutic options to manage the ongoing pandemic. Given circa 7817 licenced compounds available from Compounds Australia that ca
Externí odkaz:
https://doaj.org/article/f5bfde929e31460aa993d8fbbab0208e
Autor:
Vinod Sundaramoorthy, Nathan Godde, Ryan J. Farr, Diane Green, John M. Haynes, John Bingham, Carmel M. O’Brien, Megan Dearnley
Publikováno v:
Viruses, Vol 12, Iss 4, p 359 (2020)
Rabies is a zoonotic neurological infection caused by lyssavirus that continues to result in devastating loss of human life. Many aspects of rabies pathogenesis in human neurons are not well understood. Lack of appropriate ex-vivo models for studying
Externí odkaz:
https://doaj.org/article/9b3aff3cb3c74c0b83b05ddf92256103
Autor:
Esther Lestrell, Yaping Chen, Stella Aslanoglou, Carmel M. O’Brien, Roey Elnathan, Nicolas H. Voelcker
Publikováno v:
ACS applied materialsinterfaces. 14(40)
Cell nuclear size and shape are strictly regulated, with aberrations often leading to or being indicative of disease. Nuclear mechanics are critically responsible for intracellular responses to extracellular cues, such as the nanotopography of the ex
Autor:
Anna L. Leichter, Carmel M. O’Brien, David R. Powell, Hun S. Chy, Jahnvi Pflueger, Ziyi Huang, Guizhi Sun, Amander T. Clark, Joseph Chen, Jacob M. Paynter, Andrew L. Laslett, Xin Yi Choo, Sam Buckberry, Christian M. Nefzger, Haroon Naeem, Jaber Firas, Pratibha Tripathi, John F. Ouyang, Vincent Tano, Daniela S. Valdes, Jia Ping Tan, Susan K. Nilsson, Michael R. Larcombe, Daniel Poppe, Di Chen, Fernando J. Rossello, Jan Schröder, Xiaodong Liu, Alexandra Grubman, Anja S Knaupp, Owen J. L. Rackham, Jose M. Polo, Ryan Lister, Yu Bo Yang Sun, Luciano G. Martelotto, Laurent David, William A. Pastor, Kathryn C. Davidson, Partha Pratim Das
Publikováno v:
Nature. 586:101-107
The reprogramming of human somatic cells to primed or naive induced pluripotent stem cells recapitulates the stages of early embryonic development 1–6. The molecular mechanism that underpins these reprogramming processes remains largely unexplored,
Publikováno v:
Acta Biomaterialia. 101:102-116
This study investigates the utility of a tailored poly(ethylene glycol) diacrylate-crosslinked porous polymeric tissue engineering scaffold, with mechanical properties specifically optimised to be comparable to that of mammalian brain tissue for 3D h
Publikováno v:
Acta biomaterialia. 135
Commercial nerve guidance conduits (NGCs) for repair of peripheral nerve discontinuities are of little use in gaps larger than 30 mm, and for smaller gaps they often fail to compete with the autografts that they are designed to replace. While recent
Autor:
Nathan Godde, Megan Dearnley, Diane Green, John M. Haynes, Ryan J. Farr, Carmel M. O’Brien, John Bingham, Vinod Sundaramoorthy
Publikováno v:
Viruses
Volume 12
Issue 4
Viruses, Vol 12, Iss 4, p 359 (2020)
Volume 12
Issue 4
Viruses, Vol 12, Iss 4, p 359 (2020)
Rabies is a zoonotic neurological infection caused by lyssavirus that continues to result in devastating loss of human life. Many aspects of rabies pathogenesis in human neurons are not well understood. Lack of appropriate ex-vivo models for studying
Publikováno v:
Advanced Therapeutics. 4:2100061
Autor:
Margeaux Hodgson-Garms, Ethan Ford, Joseph Chen, Jahnvi Pflueger, Jacob M. Paynter, Carmel M. O’Brien, Cheng Huang, Susan K. Nilsson, Ketan Mishra, Christian M. Nefzger, Andrew L. Laslett, Natasha Jansz, Xiaodong Liu, Sarah M. Williams, Fernando J. Rossello, Ralf B. Schittenhelm, Hun S. Chy, Anja S Knaupp, Marnie E. Blewitt, Jose M. Polo, Ryan Lister, Jaber Firas
Publikováno v:
Nature Methods. 14:1055-1062
Recent reports on the characteristics of naive human pluripotent stem cells (hPSCs) obtained using independent methods differ. Naive hPSCs have been mainly derived by conversion from primed hPSCs or by direct derivation from human embryos rather than