Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity

Autor: Silvia Panarello, Aleix González-Díez, Alice E. Berizzi, Fanny Malhaire, Roser Borràs-Tudurí, Xavier Rovira, Carme Serra, Laurent Prézeau, Jean-Philippe Pin, Cyril Goudet, Amadeu Llebaria, Xavier Gómez-Santacana

Publikováno v: iScience, Vol 27, Iss 6, Pp 110123- (2024)

Summary: Metabotropic glutamate receptors (mGlu) regulate multiple functions in the nervous systems and are involved in several neurological disorders. However, selectively targeting individual mGlu subtypes with spatiotemporal precision is still an

Externí odkaz: https://doaj.org/article/b18db773dee3473cb3b7f29e86502ea3

Bariatric surgery and LDL cholesterol (BASALTO) trial study protocol: randomised controlled study evaluating the effect of gastric bypass versus sleeve gastrectomy on high LDL cholesterol

Autor: David Benaiges, Albert Goday, Juana A Flores-Le Roux, Montserrat Fitó, Oscar Pozo, Jose Rodríguez-Morató, Carme Serra, Manuel Pera, Gemma Llauradó, Elisenda Climent, Olga Castañer, Jose M Ramon, Juan Pedro-Botet

Publikováno v: BMJ Open, Vol 10, Iss 9 (2020)

Introduction Observational studies have shown gastric bypass to be superior to sleeve gastrectomy in terms of low-density lipoprotein (LDL) cholesterol improvement. If these results are confirmed in randomised controlled trials, presurgical LDL chole

Externí odkaz: https://doaj.org/article/0ff7a68f3f81441c9b689de8ad4b12bb

A Novel Family of Lysosomotropic Tetracyclic Compounds for Treating Leukemia

Autor: José M. Carbó, Josep M. Cornet-Masana, Laia Cuesta-Casanovas, Jennifer Delgado-Martínez, Antònia Banús-Mulet, Lise Clément-Demange, Carme Serra, Juanlo Catena, Amadeu Llebaria, Jordi Esteve, Ruth M. Risueño

Publikováno v: Cancers; Volume 15; Issue 6; Pages: 1912

Acute myeloid leukemia (AML) is a heterogeneous hematological cancer characterized by poor prognosis and frequent relapses. Aside from specific mutation-related changes, in AML, the overall function of lysosomes and mitochondria is drastically altere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378eda04dc8e34603f1902a3e7f6d3b5
http://hdl.handle.net/10261/306238

Identification of differential polypharmacology between the PARP inhibitor rucaparib and its major metabolite

Autor: Huabin Hu, Carme Serra, Amadeu Llebaria, Albert A. Antolin

The (poly)pharmacology of drug metabolites is seldom comprehensively characterized in drug discovery and development. However, some drug metabolites can reach high plasma concentrations and display relevant in vivo activity, which can be distinct fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668ca5b4e9fc4eaa0c64af4cf342c1a3
https://doi.org/10.1101/2022.11.22.517505

Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses

Autor: Amadeu Llebaria, Punyanganie S. de Silva, Joana F. Neves, Shankar S. Iyer, Thomas Gensollen, Gurdyal S. Besra, Richard S. Blumberg, Frédéric Collin, Anthony Maxwell, Russell Hauser, Sungwhan F. Oh, R. Balfour Sartor, Amit Gandhi, Jonathan N. Glickman, Carme Serra, Richard Lavin

Publikováno v: Iyer, S S, Gensollen, T, Gandhi, A, Oh, S F, Neves, J F, Collin, F, Lavin, R, Serra, C, Glickman, J N, de Silva, P S A, Sartor, R B, Besra, G, Hauser, R, Maxwell, A, Llebaria, A & Blumberg, R S 2018, ' Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses. ', Cell, vol. 173, no. 5, pp. 1123-1134.e11 . https://doi.org/10.1016/j.cell.2018.04.037

Genome-wide association studies have identified risk loci associated with the development of inflammatory bowel disease, while epidemiological studies have emphasized that pathogenesis likely involves host interactions with environmental elements who

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b85349a98d325b020d4ab824900ec41
https://doi.org/10.1016/j.cell.2018.04.037