Výsledky vyhledávání - "Carme Sarries"

Mutations in the tyrosine kinase domain of the EGFR gene associated with gefitinib response in non-small-cell lung cancer

Autor: María del Cristo Rodríguez Pérez, Kenichi Nishiyama, Jose Miguel Sanchez, Pedro Mendez, Teresa Moran, Cristina Queralt, Yukito Ichinose, Rafael Rosell, Miquel Taron, Jose Luis Mate, Carme Sarries, Beatriz Cirauqui, Jose Javier Sanchez, Benjamin Besse, Noemi Reguart

Publikováno v: Lung Cancer. 50:25-33

The potential relevance of epidermal growth factor receptor (EGFR) mutations to non-small-cell lung cancer treatment has recently been identified. We have examined the presence of EGFR mutations in Japanese and Spanish gefitinib-treated non-small-cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e41e05d201b9f59588bb595fda683f
https://doi.org/10.1016/j.lungcan.2005.05.017

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Single nucleotide polymorphisms and outcome in docetaxel–cisplatin-treated advanced non-small-cell lung cancer

Autor: Marta López-Brea, Dolores Isla, Carme Sarries, A. Paredes, B. Medina, L. Nuñez, Manuel Domine, Guillermo Lopez-Vivanco, Maria Sanchez-Ronco, M. Botia, Jose Javier Sanchez, Guillermo Alonso, Rafael Rosell, Angel Artal, Isidoro Barneto, Pilar Lianes, Miquel Taron, Carlos Camps

Publikováno v: Annals of Oncology. 15:1194-1203

Background: Platinum-based doublets are the standard chemotherapy for advanced non-small-cell lung cancer (NSCLC). Excision-repair cross-complementing 1 (ERCC1), xeroderma pigmentosum group D (XPD) and ribonucleotide reductase subunit M1 (RRM1) are e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8daf169b8c528603e6eb8a40865d9147
https://doi.org/10.1093/annonc/mdh319

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Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients

Autor: Miquel Taron, Mireia Margeli, Rafael Rosell, Carme Sarries, Barbara Roig, Jose Miguel Sanchez, Jose Luis Ramirez, Itziar de Aguirre, Cristina Queralt, Julio Astudillo, Jose Luis Manzano, Jose Javier Sanchez, Pedro López de Castro, Daniel Escuin

Publikováno v: Cancer letters. 193(2)

Gene methylation and K-ras mutations were examined in tumor and paired serum DNA of 50 resected non-small-cell lung cancer patients. RASSF1A, death associated protein kinase and target of methylation-induced silencing were methylated in 17/50 (34%),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b430f25f25079a93d5e1bb78031e6879
https://pubmed.ncbi.nlm.nih.gov/14744528

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O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme

Autor: Carme, Balaña, Jose Luis, Ramirez, Miquel, Taron, Yannis, Roussos, Aurelio, Ariza, Rosa, Ballester, Carme, Sarries, Pedro, Mendez, Jose Javier, Sanchez, Rafael, Rosell

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 9(4)

In glioblastoma multiforme (GBM), the cytotoxic effect of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and temozolamide is dependent on O(6) alkylation, which correlates inversely with expression of the DNA repair enzyme O(6)-methyl-guanine-DNA methyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5c952c3b8fd9a40e6c9c8d44394b0e3
https://pubmed.ncbi.nlm.nih.gov/12684420

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Nucleotide excision repair pathways involved in cisplatin resistance in non-small-cell lung cancer

Autor: Agustí Barnadas, Rafael Rosell, Carme Sarries, Miquel Taron, Barbara Roig, Giorgio V. Scagliotti

In spite of the growing list of genetic abnormalities identified as being involved in DNA repair pathways that alter chemosensitivity in non-small-cell lung cancer (NSCLC) patients, translational assays have not yet been developed for use in individu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5adba77b95edfc5ff219d52d0a377b
http://hdl.handle.net/2318/1691276

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Pharmacogenomic strategies for developing customized chemotherapy in non-small cell lung cancer

Autor: Albert Abad, Rafael Rosell, Carme Sarries, Barbara Roig, Miquel Taron, Eric B. Haura, Giorgio V. Scagliotti

Publikováno v: Pharmacogenomics. 3(6)

We deal with six groups of cytotoxic drugs commonly used in the treatment of non-small cell lung cancer (NSCLC). Although there are many reviews of thymidylate synthase (TS) and antifolate inhibitors, in this article, we have tried to highlight aspec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900b3bed344c0cfc3a2e12a71c632f57
https://pubmed.ncbi.nlm.nih.gov/12437479

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β-Tubulin mutational analysis: tantalizing findings

Autor: Cristina Queralt, Barbara Roig, Rafael Rosell, Carme Sarries, Miquel Taron

Publikováno v: Lung Cancer. 38:99-100

Resistance to taxanes could be due to alterations in the intracellular target, tubulin. Such alterations can include decreased tubulin, point mutations, altered expression of b-tubulin isotypes and acetylation of atubulin. Acquired b-tubulin mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452d4c94ddefce5eab8280c30d4eb499
https://doi.org/10.1016/s0169-5002(02)00188-5

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