Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Carly R. Desmond"'
Autor:
Claudia L.K. Hung, Laura E Bowie, Carly R. Desmond, Tamara Maiuri, Ray Truant, Jianrun Xia, Susie Son
Publikováno v:
Journal of Biological Chemistry. 294:1915-1923
Huntington's disease (HD) is a neurodegenerative, age-onset disorder caused by a CAG DNA expansion in exon 1 of the HTT gene, resulting in a polyglutamine expansion in the huntingtin protein. Nuclear accumulation of mutant huntingtin is a hallmark of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a7430ce99693c2bfddaa6394203ab6
https://doi.org/10.1074/jbc.ra117.001440
https://doi.org/10.1074/jbc.ra117.001440
Publikováno v:
Proceedings of the National Academy of Sciences. 110:14610-14615
Huntington disease (HD) is a neurodegenerative disorder caused by a CAG expansion within the huntingtin gene that encodes a polymorphic glutamine tract at the amino terminus of the huntingtin protein. HD is one of nine polyglutamine expansion disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3105195473d24a93966f6755b349a2e4
https://doi.org/10.1073/pnas.1301342110
https://doi.org/10.1073/pnas.1301342110
Publikováno v:
FEBS Journal. 275:4252-4262
After the successful cloning of the first gene for a polyglutamine disease in 1991, the expanded polyglutamine tract in the nine polyglutamine disease proteins became an obvious therapeutic target. Early hypotheses were that misfolded, precipitated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::531ff37f37a15e88f91b10401fd78065
https://doi.org/10.1111/j.1742-4658.2008.06561.x
https://doi.org/10.1111/j.1742-4658.2008.06561.x
Publikováno v:
The Journal of biological chemistry. 287(47)
Among the known pathways of protein nuclear import, the karyopherin β2/transportin pathway is only the second to have a defined nuclear localization signal (NLS) consensus. Huntingtin, a 350-kDa protein, has defined roles in the nucleus, as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71912df85129189b81725a665bfc4312
https://pubmed.ncbi.nlm.nih.gov/23012356
https://pubmed.ncbi.nlm.nih.gov/23012356
Publikováno v:
Journal of Cell Science.
Cofilin protein is involved in regulating the actin cytoskeleton during typical steady state conditions, as well as during cell stress conditions where cofilin saturates F-actin forming cofilin-actin rods. Cofilin can enter the nucleus through an act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e41daa3f6847d2b340d23f5e4eb67cfd
https://doi.org/10.1242/jcs.097667
https://doi.org/10.1242/jcs.097667
Autor:
Randy Singh Atwal, Ray Truant, Jianrun Xia, Carly R. Desmond, Simonetta Sipione, Tamara Maiuri, Nicholas S. Caron
Publikováno v:
Nature chemical biology. 7(7)
Two serine residues within the first 17 amino acid residues of huntingtin (N17) are crucial for modulation of mutant huntingtin toxicity in cell and mouse genetic models of Huntington's disease. Here we show that the stress-dependent phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1005eff478df2fe568fc6ad9cf2655
https://pubmed.ncbi.nlm.nih.gov/21685885
https://pubmed.ncbi.nlm.nih.gov/21685885
Publikováno v:
Communicative & Integrative Biology
Nuclear accumulation of the polyglutamine-expanded mutant huntingtin protein remains one of the most predictive cell biological phenotypes of Huntington’s disease (HD) progression in patient brain samples and mouse models of the disease. Yet, the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6163dbc22620e9e0bb8c7e3210043d5b
https://doi.org/10.4161/cib.23318
https://doi.org/10.4161/cib.23318
Publikováno v:
Nature Methods. 6:317-317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42b1d8bc8eb6be7252966dddeb2e5082
https://doi.org/10.1038/nmeth0509-317
https://doi.org/10.1038/nmeth0509-317