Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Carly M. Sayers"'
Autor:
Joshua D. Mannheimer, Gregory Tawa, David Gerhold, John Braisted, Carly M. Sayers, Troy A. McEachron, Paul Meltzer, Christina Mazcko, Jessica A. Beck, Amy K. LeBlanc
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract Canine osteosarcoma is increasingly recognized as an informative model for human osteosarcoma. Here we show in one of the largest clinically annotated canine osteosarcoma transcriptional datasets that two previously reported, as well as de n
Externí odkaz:
https://doaj.org/article/2c94461c7d05411c96992ac3641930f3
Autor:
Xiyuan Zhang, Hannah E. Lou, Vishaka Gopalan, Zhihui Liu, Hilda M. Jafarah, Haiyan Lei, Paige Jones, Carly M. Sayers, Marielle E. Yohe, Prashant Chittiboina, Brigitte C. Widemann, Carol J. Thiele, Michael C. Kelly, Sridhar Hannenhalli, Jack F. Shern
Publikováno v:
Cell Reports. 40:111363
Loss-of-function mutations in the polycomb repressive complex 2 (PRC2) occur frequently in malignant peripheral nerve sheath tumor, an aggressive sarcoma that arises from NF1-deficient Schwann cells. To define the oncogenic mechanisms underlying PRC2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1351074c631e3b9614f7a1b3c17cd0
https://doi.org/10.1016/j.celrep.2022.111363
https://doi.org/10.1016/j.celrep.2022.111363
Autor:
Hsien-Chao Chou, Anna M. Chiarella, Jiji Chen, Javed Khan, Sukriti Bagchi, Xinyu Wen, Ranu S Sinniah, Ashley Walton, Nathaniel A. Hathaway, Silvia Pomella, Young Min Song, Jack F. Shern, Xiaoli S. Wu, Christopher R. Vakoc, Benjamin Z. Stanton, Berkley E. Gryder, Keji Zhao, Rossella Rota, Carly M. Sayers
Publikováno v:
Nature genetics
Core regulatory transcription factors (CR TFs) orchestrate the placement of super-enhancers (SEs) to activate transcription of cell-identity specifying gene networks, and are critical in promoting cancer. Here, we define the core regulatory circuitry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003017e0b7efbc5cd501cf8f53fed6b3
http://europepmc.org/articles/PMC6886578
http://europepmc.org/articles/PMC6886578
Autor:
Xiyuan Zhang, Hannah E. Lou, Vishaka Gopalan, Zhihui Liu, Hilda Jafarah, Haiyan Lei, Paige Jones, Carly M. Sayers, Marielle E. Yohe, Prashant Chittiboina, Brigitte C. Widemann, Carol J. Thiele, Michael C. Kelly, Sridhar Hannenhalli, Jack F. Shern
Publikováno v:
Cancer Research. 82:701-701
Objective: Recurrent mutations in the polycomb repressive complex 2 (PRC2) occur in ~80% of malignant peripheral nerve sheath tumors (MPNST), which originate from NF1-deficient Schwann cells. In MPNST, PRC2 loss results in a diverse set of transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6582c5e6acb60ffcde31b4e7705423f7
https://doi.org/10.1158/1538-7445.am2022-701
https://doi.org/10.1158/1538-7445.am2022-701
Autor:
Xiyuan Zhang, Carly M. Sayers, Zhihui Liu, Hannah E. Lou, Haiyan Lei, Vishaka Gopalan, Prashant Chittiboina, Catherine Paige Jones, Brigitte C. Widemann, Michael C. Kelly, Marielle E. Yohe, Carol J. Thiele, John F. Shern, Sridhar Hannenhalli
Publikováno v:
SSRN Electronic Journal.
Genetic alterations that result in the dysregulation of polycomb repressive complex 2 (PRC2) are common features of multiple cancer types. Loss-of-function mutations in the PRC2 genes, SUZ12 or EED, occur at high frequency in malignant peripheral ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45f126043ad8b1251336107f4cf09994
https://doi.org/10.2139/ssrn.3919932
https://doi.org/10.2139/ssrn.3919932
Autor:
Jack F. Shern, Steven Shema, Craig J. Thomas, Kelli M. Wilson, Haiyan Lei, Carly M. Sayers, Xiaohu Zhang, Lu Chen, Morgan B. Carter
Publikováno v:
Cancer Research. 80:457-457
Ewing sarcoma (EWS), a highly aggressive bone and soft tissue cancer occurring in children and young adults, is characterized by FET-ETS family gene fusions. Although event-free survival rates remain high in EWS patients with localized disease, those
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::109f07e06a86536d0d64c3ced7c21f6c
https://doi.org/10.1158/1538-7445.am2020-457
https://doi.org/10.1158/1538-7445.am2020-457
Autor:
Constantinos Koumenis, David M. Guttmann, Eric S. Witze, Albert C. Koong, Nancy L. Maas, J. Alan Diehl, Carly M. Sayers, Ioanna Papandreou
Publikováno v:
Molecular Pharmacology. 83:594-604
The Integrated Stress Response (ISR) is a signaling program that enables cellular adaptation to stressful conditions like hypoxia and nutrient deprivation in the tumor microenvironment. An important effector of the ISR is activating transcription fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c713766afc133be89c434359faca60fc
https://doi.org/10.1124/mol.112.081810
https://doi.org/10.1124/mol.112.081810
Autor:
X. S. Wan, Ann R. Kennedy, Carly M. Sayers, Jeffrey H. Ware, Manunya Nuth, Adam Rusek, Gabriel Krigsfeld, Jenine K. Sanzari, Stephen Avery
Publikováno v:
Radiation Research. 174:325-330
The present study evaluated the acute effects of radiation dose, dose rate and fractionation as well as the energy of protons in hematopoietic cells of irradiated mice. The mice were irradiated with a single dose of 51.24 MeV protons at a dose of 2 G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cb9cbc6a0a0e14c1ecbaa809df784a
https://doi.org/10.1667/rr1979.1
https://doi.org/10.1667/rr1979.1
Autor:
J. Alan Diehl, Stacey L. Lehman, Paul J. Zhang, George J. Cerniglia, Carly M. Sayers, Serge Y. Fuchs, Stephen W. Tuttle, Ioannis I. Verginadis, Souvik Dey, Michael Feldman, Constantinos Koumenis, Yi Cheng
The integrated stress response (ISR) is a critical mediator of cancer cell survival, and targeting the ISR inhibits tumor progression. Here, we have shown that activating transcription factor 4 (ATF4), a master transcriptional effector of the ISR, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b29706cc1609e8ac42242a866d8732
https://europepmc.org/articles/PMC4563676/
https://europepmc.org/articles/PMC4563676/
Publikováno v:
Hypoxia and Cancer ISBN: 9781461491668
Tumor cells employ multiple elaborate, evolutionarily conserved mechanisms that enable them to respond to stress conditions in the tumor microenvironment, including hypoxia. Although the most studied cellular signaling pathway induced by hypoxia is m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17498569db605f34ede157e97d39a3e0
https://doi.org/10.1007/978-1-4614-9167-5_10
https://doi.org/10.1007/978-1-4614-9167-5_10