Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Carly M. Knuth"'
Autor:
Carly M. Knuth, Dalia Barayan, Ju Hee Lee, Christopher Auger, Lauar de Brito Monteiro, Zachary Ricciuti, Dea Metko, Lisa Wells, Hoon-Ki Sung, Robert A. Screaton, Marc G. Jeschke
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113584- (2024)
Summary: Severe burns induce a chronic hypermetabolic state that persists well past wound closure, indicating that additional internal mechanisms must be involved. Adipose tissue is suggested to be a central regulator in perpetuating hypermetabolism,
Externí odkaz:
https://doaj.org/article/28447df79fd644b48867df243ef615fa
Autor:
Christopher Auger, Carly M. Knuth, Abdikarim Abdullahi, Osai Samadi, Alexandra Parousis, Marc G. Jeschke
Publikováno v:
Molecular Metabolism, Vol 29, Iss , Pp 12-23 (2019)
Objective: Browning, the conversion of white adipose tissue (WAT) to a beige phenotype, has gained interest as a strategy to induce weight loss and improve insulin resistance in metabolic disorders. However, for hypermetabolic conditions stemming fro
Externí odkaz:
https://doaj.org/article/895ff41249ce44a5af0335fc4220500a
Autor:
Abdikarim Abdullahi, Carly M. Knuth, Christopher Auger, Thibacg Sivayoganathan, Alexandra Parousis, Marc G. Jeschke
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
BACKGROUND The incidence of burn injuries in older patients is dramatically increasing as the population of older people grows. Despite the increased demand for elderly burn care, the mechanisms that mediate increased morbidity and mortality in older
Externí odkaz:
https://doaj.org/article/a01eb3d9c691406385647f9429e3c99b
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Severe burn-induced inflammation and subsequent hypermetabolic response can lead to profound infection and sepsis, resulting in multiple organ failure and high mortality risk in patients. This represents an extremely challenging issue for clinicians
Externí odkaz:
https://doaj.org/article/809da06ed0db4b0fb25c8587e5542245
Autor:
Supreet Kaur, Christopher Auger, Dalia Barayan, Priyal Shah, Anna Matveev, Carly M. Knuth, Thurl E. Harris, Marc G. Jeschke
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Abstract Hypermetabolism following severe burn injuries is associated with adipocyte dysfunction, elevated beige adipocyte formation, and increased energy expenditure. The resulting catabolism of adipose leads to detrimental sequelae such as fatty li
Externí odkaz:
https://doaj.org/article/49d63209710d49869a903e83f5759917
Publikováno v:
Shock (Augusta, Ga.). 58(2)
Sepsis has become the leading cause of death in burn patients. Furthermore, sepsis and septic complications result in significant morbidities and longer hospitalization, which has profound impacts on the healthcare system. Despite this, sepsis in bur
Autor:
Carly M. Knuth, Zachary Ricciuti, Dalia Barayan, Sarah Rehou, Abdikarim Abdullahi, Lauar de Brito Monteiro, Marc G. Jeschke
Publikováno v:
Annals of Surgery.
Autor:
Ichitaro Abe, Yasuo Oguri, Anthony R.P. Verkerke, Lauar B. Monteiro, Carly M. Knuth, Christopher Auger, Yunping Qiu, Gregory P. Westcott, Saverio Cinti, Kosaku Shinoda, Marc G. Jeschke, Shingo Kajimura
Publikováno v:
Developmental cell. 57(23)
De novo beige adipocyte biogenesis involves the proliferation of progenitor cells in white adipose tissue (WAT); however, what regulates this process remains unclear. Here, we report that in mouse models but also in human tissues, WAT lipolysis-deriv
Autor:
Ichitaro Abe, Yasuo Oguri, Anthony R.P. Verkerke, Lauar B. Monteiro, Carly M. Knuth, Christopher Auger, Yunping Qiu, Gregory P. Westcott, Saverio Cinti, Kosaku Shinoda, Marc G. Jeschke, Shingo Kajimura
Publikováno v:
SSRN Electronic Journal.