Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Carly Kiselycznyk"'
Autor:
Mounira Banasr, Colin N. Haile, Ryan Webler, Carly Kiselycznyk, Sanjay J. Mathew, Samuel T. Wilkinson
Publikováno v:
Journal of Affective Disorders. 241:514-518
Background Serum brain-derived neurotrophic factor (BDNF) is decreased in individuals with major depressive disorder (MDD). Pre-clinical and clinical reports suggest that the glutamate release inhibitor riluzole increases BDNF and may have antidepres
Autor:
Carly Kiselycznyk, Rolf Sprengel, Lindsay R. Halladay, Masayoshi Mishina, Andrew Holmes, Per Svenningsson, Seth G. N. Grant, Nicholas J. Jury, Kazu Nakazawa
Publikováno v:
Behavioural Brain Research
Drugs targeting the glutamate N-methyl-D-aspartate receptor (NMDAR) may be efficacious for treating mood disorders, as exemplified by the rapid antidepressant effects produced by single administration of the NMDAR antagonist ketamine. Though the prec
Autor:
J. Nicholas P. Rawlins, Carly Kiselycznyk, David M. Bannerman, Lisa M. Saksida, Lisa M. Wiedholz, Carolyn Graybeal, Wolfram B. Schmitt, Tara Wright, Alicia Izquierdo, Rolf Sprengel, Michael Feyder, Chris Barkus, Andrew Holmes, David J. Sanderson, Timothy J. Bussey
Publikováno v:
Neuropharmacology
The glutamate system has been strongly implicated in the pathophysiology of psychotic illnesses, including schizophrenia and schizoaffective disorder. We recently found that knockout (KO) mice lacking the AMPA GluA1 subunit displayed behavioral abnor
Autor:
Andrew Holmes, Ozge Gunduz-Cinar, Aaron Plitt, Masayoshi Mishina, Benita Hurd, Seth G. N. Grant, Lauren DeBrouse, Alyssa Todaro, Marguerite Camp, Carly Kiselycznyk
Publikováno v:
Alcoholism: Clinical and Experimental Research
Alcoholism: Clinical and Experimental Research; Vol 37
DeBrouse, L, Hurd, B, Kiselycznyk, C, Plitt, A, Todaro, A, Mishina, M, Grant, S G N, Camp, M, Gunduz-Cinar, O & Holmes, A 2013, ' Probing the Modulation of Acute Ethanol Intoxication by Pharmacological Manipulation of the NMDAR Glycine Co-Agonist Site ', Alcoholism: Clinical and Experimental Research, vol. 37, no. 2, pp. 223-233 . https://doi.org/10.1111/j.1530-0277.2012.01922.x
Alcoholism: Clinical and Experimental Research; Vol 37
DeBrouse, L, Hurd, B, Kiselycznyk, C, Plitt, A, Todaro, A, Mishina, M, Grant, S G N, Camp, M, Gunduz-Cinar, O & Holmes, A 2013, ' Probing the Modulation of Acute Ethanol Intoxication by Pharmacological Manipulation of the NMDAR Glycine Co-Agonist Site ', Alcoholism: Clinical and Experimental Research, vol. 37, no. 2, pp. 223-233 . https://doi.org/10.1111/j.1530-0277.2012.01922.x
Background Stimulating the glycineB binding site on the N-methyl-d-aspartate ionotropic glutamate receptor (NMDAR) has been proposed as a novel mechanism for modulating behavioral effects of ethanol (EtOH) that are mediated via the NMDAR, including a
Publikováno v:
Neuroscience. 193:259-268
Glutamate and N-methyl-d-aspartate receptor (NMDAR) dysfunction is strongly implicated in the pathophysiology of mood and anxiety disorders. Treatment with NMDAR antagonists has antidepressant efficacy in treatment-resistant depressives. In preclinic
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2006, 103 (36), pp.13543-13548. ⟨10.1073/pnas.0602750103⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2006, 103 (36), pp.13543-13548. ⟨10.1073/pnas.0602750103⟩
A number of electrophysiological experiments have shown that odor exposure alone, unaccompanied by behavioral training, changes the response patterns of neurons in the olfactory bulb. As a consequence of these changes, across mitral cells in the olfa
Autor:
Carly Kiselycznyk, Gerard Sanacora
Publikováno v:
Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders ISBN: 9781493910557
The majority of treatments for neuropsychiatric disorders have been based on serendipitous discoveries, with little understanding of the pathogenic and pathophysiological mechanisms underlying these disorders. As many of these disorders are sensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16db08d73c2abe0094e9e7499606e648
https://doi.org/10.1007/978-1-4939-1056-4_17
https://doi.org/10.1007/978-1-4939-1056-4_17
Publikováno v:
The international journal of neuropsychopharmacology. 16(4)
Anxiety and depression are highly prevalent and frequently co-morbid conditions. The ionotropic glutamate receptors N-methyl-d-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) mediate actions of monoaminergic antidepressants
The prefrontal cortex (PFC) mediates higher-order cognitive and executive functions that subserve various complex, adaptable behaviors, such as cognitive flexibility, attention, and working memory. Deficits in these functions typify multiple neuropsy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac744e424bb54c0639846961f8a31d63
https://europepmc.org/articles/PMC3351527/
https://europepmc.org/articles/PMC3351527/
Autor:
Daniel F Fisher, Jason A. Bubier, Andrew Holmes, Lauren Lederle, Benita Hurd, Elissa J. Chesler, Aaron Plitt, Carly Kiselycznyk
Publikováno v:
Mammalian Genome
Individual variation in sensitivity to acute ethanol (EtOH) challenge is associated with alcohol drinking and is a predictor of alcohol abuse. Previous studies have shown that the C57BL/6J (B6) and 129S1/SvImJ (S1) inbred mouse strains differ in resp