The upregulation of K ⁺ and HCN channels in developing spiral ganglion neurons is mediated by cochlear inner hair cells.

Autor: Conrad LJ; School of Biosciences, University of Sheffield, Sheffield, UK., Grandi FC; INSERM, Institute de Myologie, Centre de Recherche en Myologie F-75013, Sorbonne Université, Paris, France., Carlton AJ; School of Biosciences, University of Sheffield, Sheffield, UK., Jeng JY; School of Biosciences, University of Sheffield, Sheffield, UK., de Tomasi L; School of Biosciences, University of Sheffield, Sheffield, UK., Zarecki P; School of Biosciences, University of Sheffield, Sheffield, UK., Marcotti W; School of Biosciences, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK., Johnson SL; School of Biosciences, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK., Mustapha M; School of Biosciences, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK.

Publikováno v: The Journal of physiology [J Physiol] 2024 Oct; Vol. 602 (20), pp. 5329-5351. Date of Electronic Publication: 2024 Sep 26.

A critical period of prehearing spontaneous Ca ²⁺ spiking is required for hair-bundle maintenance in inner hair cells.

Autor: Carlton AJ; School of Biosciences, University of Sheffield, Sheffield, UK., Jeng JY; School of Biosciences, University of Sheffield, Sheffield, UK., Grandi FC; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., De Faveri F; School of Biosciences, University of Sheffield, Sheffield, UK., Ceriani F; School of Biosciences, University of Sheffield, Sheffield, UK., De Tomasi L; School of Biosciences, University of Sheffield, Sheffield, UK., Underhill A; School of Biosciences, University of Sheffield, Sheffield, UK., Johnson SL; School of Biosciences, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK., Legan KP; School of Life Sciences, University of Sussex, Falmer, Brighton, UK., Kros CJ; School of Life Sciences, University of Sussex, Falmer, Brighton, UK., Richardson GP; School of Life Sciences, University of Sussex, Falmer, Brighton, UK., Mustapha M; School of Biosciences, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK., Marcotti W; School of Biosciences, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK.

Publikováno v: The EMBO journal [EMBO J] 2023 Feb 15; Vol. 42 (4), pp. e112118. Date of Electronic Publication: 2023 Jan 03.

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing.

Autor: Newton S; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Oxford, United Kingdom., Kong F; School of Sciences, University of Sheffield, Sheffield, United Kingdom., Carlton AJ; School of Sciences, University of Sheffield, Sheffield, United Kingdom., Aguilar C; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Oxford, United Kingdom., Parker A; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Oxford, United Kingdom., Codner GF; Mary Lyon Centre, MRC Harwell Institute, Harwell Oxford, United Kingdom., Teboul L; Mary Lyon Centre, MRC Harwell Institute, Harwell Oxford, United Kingdom., Wells S; Mary Lyon Centre, MRC Harwell Institute, Harwell Oxford, United Kingdom., Brown SDM; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Oxford, United Kingdom., Marcotti W; School of Sciences, University of Sheffield, Sheffield, United Kingdom.; Sheffield Neuroscience Institute, University of Sheffield, Sheffield, United Kingdom., Bowl MR; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Oxford, United Kingdom.; UCL Ear Institute, University College London, London, United Kingdom.

Publikováno v: PLoS genetics [PLoS Genet] 2022 Jan 31; Vol. 18 (1), pp. e1009937. Date of Electronic Publication: 2022 Jan 31 (Print Publication: 2022).

Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness.

Autor: Carlton AJ; Department of Biomedical Science, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK., Halford J; Oregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland, OR, USA., Underhill A; Department of Biomedical Science, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK., Jeng JY; Department of Biomedical Science, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK., Avenarius MR; Oregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland, OR, USA.; Present address: Department of Pathology Wexner Medical Center, The Ohio State University, Columbus, OH, USA., Gilbert ML; Oregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland, OR, USA.; Present address: US Army Medical Department Activity-Korea, Camp Humphreys, Republic of Korea., Ceriani F; Department of Biomedical Science, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK., Ebisine K; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Campus, Oxfordshire, UK., Brown SDM; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Campus, Oxfordshire, UK., Bowl MR; Mammalian Genetics Unit, MRC Harwell Institute, Harwell Campus, Oxfordshire, UK.; Present address: UCL Ear Institute, University College London, London, UK., Barr-Gillespie PG; Oregon Hearing Research Center & Vollum Institute, Oregon Health & Science University, Portland, OR, USA.; Oregon Hearing Research Center, Oregon Health & Science University, Portland, OR, USA., Marcotti W; Department of Biomedical Science, University of Sheffield, Sheffield, UK.; Neuroscience Institute, University of Sheffield, Sheffield, UK.

Publikováno v: The Journal of physiology [J Physiol] 2021 Feb; Vol. 599 (4), pp. 1173-1198. Date of Electronic Publication: 2020 Nov 26.

Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells.

Autor: Jeng JY; Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK., Johnson SL; Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK., Carlton AJ; Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK., De Tomasi L; Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK., Goodyear RJ; School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK., De Faveri F; Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK., Furness DN; School of Life Sciences, Keele University, Keele, ST5 5BG, UK., Wells S; Mary Lyon Centre, MRC Harwell Institute, Oxfordshire, UK., Brown SDM; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, UK., Holley MC; Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK., Richardson GP; School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK., Mustapha M; Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK., Bowl MR; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, UK., Marcotti W; Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK.

Publikováno v: The Journal of physiology [J Physiol] 2020 Sep; Vol. 598 (18), pp. 3891-3910. Date of Electronic Publication: 2020 Jul 22.