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Autor:
Goncalves, Maria B., Yue Wu, Clarke, Earl, Grist, John, Moehlin, Julien, Mendoza-Parra, Marco Antonio, Hobbs, Carl, Kalindjian, Barret, Fok, Henry, Mander, Adrian P., Hassanin, Hana, Bendel, Daryl, Täubel, Jörg, Mant, Tim, Carlstedt, Thomas, Jack, Julian, Corcoran, Jonathan P. T.
Publikováno v:
Frontiers in Molecular Neuroscience; 2024, p1-18, 18p
Publikováno v:
In World Neurosurgery July 2017 103:28-36
Autor:
Funakoshi, Hiroshi, Risling, Marten, Carlstedt, Thomas, Lendahl, Urban, Timmusk, Tonis, Metsis, Madis, Yamamoto, Yuji, Ibanez, Carlos F.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1998 Apr . 95(9), 5269-5274.
Externí odkaz:
https://www.jstor.org/stable/44703
Publikováno v:
In Journal of Pain June 2014 15(6):664-675
Publikováno v:
In Experimental Neurology May 2011 229(1):168-173
Autor:
Goncalves, Maria B., Clarke, Earl, Jarvis, Christopher, Kalindjian, S. Barret, Pitcher, Thomas, Grist, John, Hobbs, Carl, Carlstedt, Thomas, Jack, Julian, Brown, Jane T., Mills, Mark, Mumford, Peter, Borthwick, Alan D., Corcoran, Jonathan P.T.
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Goncalves, M B, Clarke, E, Jarvis, C, Kalindjian, S B, Pitcher, T, Grist, J, Hobbs, C, Carlstedt, T, Jack, J, Brown, J T, Mills, M, Mumford, P, Borthwick, A D & Corcoran, J P T 2019, ' Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury ', Bioorganic & medicinal chemistry letters, vol. 29, no. 8, pp. 995-1000 . https://doi.org/10.1016/j.bmcl.2019.02.011
Goncalves, M B, Clarke, E, Jarvis, C, Kalindjian, S B, Pitcher, T, Grist, J, Hobbs, C, Carlstedt, T, Jack, J, Brown, J T, Mills, M, Mumford, P, Borthwick, A D & Corcoran, J P T 2019, ' Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury ', Bioorganic & medicinal chemistry letters, vol. 29, no. 8, pp. 995-1000 . https://doi.org/10.1016/j.bmcl.2019.02.011
Graphical abstract
Oxadiazole replacement of an amide linkage in an RARα agonist template 1, followed by lead optimisation, has produced a highly potent and selective RARβ agonist 4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benzoic
Oxadiazole replacement of an amide linkage in an RARα agonist template 1, followed by lead optimisation, has produced a highly potent and selective RARβ agonist 4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benzoic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::212eb1e845c6f4ef01aa7ee308576bc8
http://europepmc.org/articles/PMC6419571
http://europepmc.org/articles/PMC6419571
Autor:
Goncalves, Maria B., Wu, Yue, Trigo, Diogo, Clarke, Earl, Malmqvist, Tony, Grist, John, Hobbs, Carl, Carlstedt, Thomas P., Corcoran, Jonathan P.T.
Publikováno v:
Neurobiology of Disease, Vol 111, Iss, Pp 70-79 (2018)
Neurobiology of Disease
Neurobiology of Disease
Stimulation of retinoic acid (RA) mediated signalling pathways following neural injury leads to regeneration in the adult nervous system and numerous studies have shown that the specific activation of the retinoic acid receptor β (RARβ) is required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::02e3619770b89d6ea61c7e6b74d71f73
http://www.sciencedirect.com/science/article/pii/S0969996117302954
http://www.sciencedirect.com/science/article/pii/S0969996117302954