Effectiveness of bevacizumab in the treatment of metastatic colorectal cancer: a systematic review and meta-analysis.

Autor: Song, Yu¹ (AUTHOR), Mao, Qianqian² (AUTHOR), Zhou, Manling³ (AUTHOR), Liu, Cheng-Jiang⁴ (AUTHOR) mrliu0420@foxmail.com, Kong, Li¹ (AUTHOR) konglizy2@163.com, Hu, Ting⁵ (AUTHOR)

Publikováno v: BMC Gastroenterology. 2/1/2024, Vol. 24 Issue 1, p1-12. 12p.

Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study.

Autor: André T; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany. thierry.andre@aphp.fr., de Gramont A; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Vernerey D; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Chibaudel B; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Bonnetain F; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Tijeras-Raballand A; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Scriva A; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Hickish T; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Tabernero J; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Van Laethem JL; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Banzi M; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Maartense E; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Shmueli E; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Carlsson GU; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Scheithauer W; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Papamichael D; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Möehler M; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Landolfi S; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Demetter P; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Colote S; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Tournigand C; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Louvet C; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Duval A; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., Fléjou JF; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany., de Gramont A; Thierry André and Jean-François Fléjou, Hôpital St Antoine; Thierry André and Jean-François Fléjou, University Pierre et Marie Curie Paris VI; Thierry André, Benoist Chibaudel, Annemilaï Tijeras-Raballand, Soudhir Colote, and Aimery de Gramont, Groupe Coopérateur Multdisciplinaire en Ocologie (GERCOR) Oncology Multidisciplinary Group and GERCOR-Innovative Research Consortium; Christophe Louvet, Institut Mutualiste Montsouris; Alex Duval, L'Institut National de la Santé et de la Recherche Médicale UMRS 938, Paris; Armand de Gramont, Benoist Chibaudel, Annemilaï, Tijeras Raballand, Aurelie Scriva, and Aimery de Gramont, Institut Hospitalier Franco Britannique, Levallois-Perret; Dewi Vernerey and Franck Bonnetain, Hôpital Saint-Jacques, Besançon; Christophe Tournigand, Hôpital Henri Mondor, Créteil, France; Armand de Gramont, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Tamas Hickish, Dorset Bournemouth University, Dorset, United Kingdom; Josep Tabernero and Stefania Landolfi, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona; Josep Tabernero, TTD Group, Madrid, Spain; Jean Luc Van Laethem and Pieter Demetter, Hôpital Universitaire Erasme, Brussels, Belgium; Maria Banzi, Arcispedale Santa Maria Nuova, Reggio, Italy; Eduard Maartense, Reinier de Graaf Groep, Delft, the Netherlands; Einat Shmueli, Sheba Medical Center, Tel Hashomer, Israel; Goran U. Carlsson, Sahlgrenska University Hospital, Östra, Sweden; Werner Scheithauer, Medical University of Vienna, Vienna, Austria; Demetris Papamichael, B.O. Cyprus Oncology Centre, Nicosia, Cyprus; and Marcus Möehler, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2015 Dec 10; Vol. 33 (35), pp. 4176-87. Date of Electronic Publication: 2015 Nov 02.

Junior doctors' experiences of the medical internship: a qualitative study.

Autor: Carlsson, Yvonne¹ yvonne.carlsson@gu.se, Nilsdotter, Anna², Bergman, Stefan¹, Liljedahl, Matilda³

Publikováno v: International Journal of Medical Education. 2022, Vol. 13, p66-73. 8p.

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells.

Autor: El-Wetidy MS; Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11823, Egypt.; College of Medicine Research Center, King Saud University, Riyadh, 11461, Kingdom of Saudi Arabia., Ahmad R; Colorectal Research Chair, Department of Surgery, College of Medicine, King Saud University, PO Box 7805 (37), Riyadh, 11472, Kingdom of Saudi Arabia. arehan@ksu.edu.sa., Rady I; Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11823, Egypt.; Department of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, 53706, USA., Helal H; Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11823, Egypt., Rady MI; Zoology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11823, Egypt., Vaali-Mohammed MA; Colorectal Research Chair, Department of Surgery, College of Medicine, King Saud University, PO Box 7805 (37), Riyadh, 11472, Kingdom of Saudi Arabia., Al-Khayal K; Colorectal Research Chair, Department of Surgery, College of Medicine, King Saud University, PO Box 7805 (37), Riyadh, 11472, Kingdom of Saudi Arabia., Traiki TB; Colorectal Research Chair, Department of Surgery, College of Medicine, King Saud University, PO Box 7805 (37), Riyadh, 11472, Kingdom of Saudi Arabia., Abdulla MH; Colorectal Research Chair, Department of Surgery, College of Medicine, King Saud University, PO Box 7805 (37), Riyadh, 11472, Kingdom of Saudi Arabia. mabdulla@ksu.edu.sa.

Publikováno v: Cell stress & chaperones [Cell Stress Chaperones] 2021 May; Vol. 26 (3), pp. 473-493. Date of Electronic Publication: 2021 Mar 05.

50 Landmark Papers Every Colorectal Surgeon Should Know

Autor: John R.T. Monson, Lawrence Lee, Fergal J. Fleming

There has been an exponential increase in the volume and quality of published research relating to colorectal disease over the last decades. This book identifies the 50 key scientific articles in the field of colorectal disease and colorectal surgery