Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Carlson Tsui"'
Autor:
Wei Shi, Daniel T. Utzschneider, Sarah S. Gabriel, Nicholas D. Huntington, Manuela Llano-León, Patrick M Gubser, David Chisanga, Laurent Bartholin, Flora Weber, Axel Kallies, Carlson Tsui, Fernando Souza-Fonseca-Guimaraes
Publikováno v:
Immunity. 54(8)
Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate, a process known as exhaustion. Exhausted T cells are sustained by precursors of exhausted (Tpex) cells that self-renew while continuously generating exhaus
Autor:
Selina Jessica Keppler, Nuria Martinez-Martin, Paula Maldonado, Marie-Charlotte Domart, Francesca Gasparrini, Marianne Burbage, Bruno Frederico, Harold B.J. Jefferies, Beatriz Montaner, Carlson Tsui, Lucy M. Collinson, Shweta Aggarwal, Usha Nair, Facundo D. Batista, Andreas Bruckbauer, Sharon A. Tooze, Mauro Gaya, Yan G. Zhao
Publikováno v:
Science. 355:641-647
Autophagy is important in a variety of cellular and pathophysiological situations; however, its role in immune responses remains elusive. Here, we show that among B cells, germinal center (GC) cells exhibited the highest rate of autophagy during vira
Autor:
Andreas Bruckbauer, Mauro Gaya, Carlson Tsui, Angus J.M. Cameron, Michael Leitges, Peter J. Parker, Paula Maldonado, Merja Rossi, Miriam Llorian, Nathalie Legrave, James I. MacRae, Nuria Martinez-Martin, Facundo D. Batista
Publikováno v:
Tsui, C, Martinez-Martin, N, Gaya, M, Maldonado, P, Llorian, M, Legrave, N M, Rossi, M, MacRae, J I, Cameron, A J, Parker, P J, Leitges, M, Bruckbauer, A & Batista, F D 2018, ' Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis ', Immunity . https://doi.org/10.1016/j.immuni.2018.04.031
1159.e1-e5
Immunity
1159.e1-e5
Immunity
Summary PKCβ-null (Prkcb−/−) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immuniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0423a04be8bec0fe9fa7b02252b4415e
https://kclpure.kcl.ac.uk/en/publications/86eea9d7-b792-404a-8e4c-f2b4bc257255
https://kclpure.kcl.ac.uk/en/publications/86eea9d7-b792-404a-8e4c-f2b4bc257255
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells
Autor:
Paula Maldonado, Khader Ghneim, Malika Aid, Usha Nair, Padraic G. Fallon, Jessica Strid, Beatriz Montaner, Dan H. Barouch, Rafick-Pierre Sekaly, Marianne Burbage, Carlson Tsui, Patricia Barral, Facundo D. Batista, Andreas Bruckbauer, Alex K. Shalek, Mauro Gaya, Andrew W. Navia, Shweta Aggarwal
Publikováno v:
Gaya, M, Barral, P, Burbage, M, Aggarwal, S, Montaner, B, Warren Navia, A, Aid, M, Tsui, C, Maldonado, P, Nair, U, Ghneim, K, Fallon, P G, Sekaly, R-P, Barouch, D H, Shalek, A K, Bruckbauer, A, Strid, J & Batista, F D 2018, ' Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells ', Cell, vol. 172, no. 3, pp. 517-533.E20 . https://doi.org/10.1016/j.cell.2017.11.036
533.e20
Elsevier
533.e20
Elsevier
B cells constitute an essential line of defense from pathogenic infections through the generation of class-switched antibody-secreting cells (ASCs) in germinal centers. Although this process is known to be regulated by follicular helper T (TfH) cells
Autor:
Carlson Tsui, Lorenz Kretschmer, Svenja Rapelius, Sarah S. Gabriel, David Chisanga, Konrad Knöpper, Daniel T. Utzschneider, Simone Nüssing, Yang Liao, Teisha Mason, Santiago Valle Torres, Stephen A. Wilcox, Krystian Kanev, Sebastian Jarosch, Justin Leube, Stephen L. Nutt, Dietmar Zehn, Ian A. Parish, Wolfgang Kastenmüller, Wei Shi, Veit R. Buchholz, Axel Kallies
Publikováno v:
Nature
CD8+ T cells that respond to chronic viral infections or cancer are characterized by the expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by the impaired production of cytokines. This state of restrained functiona