Zobrazeno 1 - 10 of 107 pro vyhledávání: '"Carlota Lopez-Cara"'
1
Akademický článek
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
Autor: Cristina C. Clement, Angelo D’Alessandro, Sangeetha Thangaswamy, Samantha Chalmers, Raquel Furtado, Sheila Spada, Giada Mondanelli, Federica Ianni, Sarah Gehrke, Marco Gargaro, Giorgia Manni, Luisa Carlota Lopez Cara, Peter Runge, Wanxia Li Tsai, Sinem Karaman, Jorge Arasa, Ruben Fernandez-Rodriguez, Amanda Beck, Antonio Macchiarulo, Massimo Gadina, Cornelia Halin, Francesca Fallarino, Mihaela Skobe, Marc Veldhoen, Simone Moretti, Silvia Formenti, Sandra Demaria, Rajesh K. Soni, Roberta Galarini, Roccaldo Sardella, Gregoire Lauvau, Chaim Putterman, Kari Alitalo, Ursula Grohmann, Laura Santambrogio
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and ne
Externí odkaz: https://doaj.org/article/95a6bc7fc7a345f08d833daae479ee94
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2
Akademický článek
Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells
Autor: Romeo Romagnoli, Filippo Prencipe, Luisa Carlota Lopez-Cara, Paola Oliva, Stefania Baraldi, Pier Giovanni Baraldi, Francisco Estévez-Sarmiento, José Quintana, Francisco Estévez
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 727-742 (2018)
The combination of two pharmacophores into a single molecule represents one of the methods that can be adopted for the synthesis of new anticancer molecules. To investigate the influence of the position of the pyridine nitrogen on biological activity
Externí odkaz: https://doaj.org/article/c952a4ba515b4ef2aa958ab1d731b780
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3
Akademický článek
New Compounds with Bioisosteric Replacement of Classic Choline Kinase Inhibitors Show Potent Antiplasmodial Activity
Autor: Francisco José Aguilar-Troyano, Archimede Torretta, Gianluca Rubbini, Alberto Fasiolo, Pilar María Luque-Navarro, María Paz Carrasco-Jimenez, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Dolores González-Pacanowska, Emilio Parisini, Luisa Carlota Lopez-Cara
Publikováno v: Pharmaceutics, Vol 13, Iss 11, p 1842 (2021)
In the fight against Malaria, new strategies need to be developed to avoid resistance of the parasite to pharmaceutics and other prevention barriers. Recently, a Host Directed Therapy approach based on the suppression of the starting materials uptake
Externí odkaz: https://doaj.org/article/4ed42e0cc01e4a2db6f69fca8a4f731c
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4
Akademický článek
Crystal Structure of the Apo and the ADP-Bound Form of Choline Kinase from Plasmodium falciparum
Autor: Archimede Torretta, Luisa Carlota Lopez-Cara, Emilio Parisini
Publikováno v: Crystals, Vol 10, Iss 7, p 613 (2020)
Among the malaria-causing parasites, the deadliest is Plasmodium falciparum, which accounts for the majority of the fatalities. As the infection progresses inside erythrocytes, major cellular and metabolic changes take place. For its own growth, the
Externí odkaz: https://doaj.org/article/c336a998a0f44108866de6fbb5ebda88
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5
Akademický článek
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6
Crystal Structure of the Apo and the ADP-Bound Form of Choline Kinase from Plasmodium falciparum
Autor: Emilio Parisini, Archimede Torretta, Luisa Carlota Lopez-Cara
Publikováno v: Crystals, Vol 10, Iss 613, p 613 (2020)
Crystals
Volume 10
Issue 7
Among the malaria-causing parasites, the deadliest is Plasmodium falciparum, which accounts for the majority of the fatalities. As the infection progresses inside erythrocytes, major cellular and metabolic changes take place. For its own growth, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf943d6254068d61357b48e290d21579
https://www.mdpi.com/2073-4352/10/7/613
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10
Anticancer and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors
Autor: Giampietro Viola, Ramon Hurtado-Guerrero, Carmen Marco, María Kimatrai-Salvador, Pilar María Luque-Navarro, Elena Mariotto, Luisa Carlota Lopez-Cara, Pablo Ríos-Marco, María Paz Carrasco-Jiménez, Santiago Schiaffino-Ortega
Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Pharmaceutics
Volume 13
Issue 9
Pharmaceutics, Vol 13, Iss 1360, p 1360 (2021)
This research was funded by Convocatoria 2019 Proyectos de I + D + i - RTI Tipo B "Ministerio de Innovacion y Ciencia" grant number PID2019-109294RB-I00 and University of Granada, Cei-BioticProject grant number CEI2013-MP-1.
Choline kinase inhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118ae8f8ccd0cb0801e411d802ec4054
http://hdl.handle.net/10481/71080
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