MEFAS, a hybrid of artesunate-mefloquine active against asexual stages of Plasmodium vivax in field isolates, inhibits malaria transmission

Autor: Julia Penna-Coutinho, Maisa da Silva Araújo, Anna Caroline Campos Aguiar, Paula Miranda Sá, Carlos Tong Rios, Jansen Fernandes Medeiros, Dhélio Batista Pereira, Nubia Boechat, Antoniana Ursine Krettli

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 150-155 (2021)

Human malaria continues to be a public health problem and an important cause of morbidity and mortality in the world. Malaria control is achieved through both individual protection against mosquito bites and drug treatment, which is hampered by the s

Externí odkaz: https://doaj.org/article/e659fd55baea4a63a26c986c1ed8c3e4

Intensive trapping of blood-fed Anopheles darlingi in Amazonian Peru reveals unexpectedly high proportions of avian blood-meals.

Autor: Marta Moreno, Marlon P Saavedra, Sara A Bickersmith, Catharine Prussing, Adrian Michalski, Carlos Tong Rios, Joseph M Vinetz, Jan E Conn

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005337 (2017)

Anopheles darlingi, the main malaria vector in the Neotropics, has been considered to be highly anthropophilic. However, many behavioral aspects of this species remain unknown, such as the range of blood-meal sources. Barrier screens were used to col

Externí odkaz: https://doaj.org/article/578687868624476fbf5ed6a860add908

MEFAS, a hybrid of artesunate-mefloquine active against asexual stages of Plasmodium vivax in field isolates, inhibits malaria transmission

Autor: Carlos Tong Rios, Julia Penna-Coutinho, Jansen Fernandes Medeiros, Nubia Boechat, Antoniana U. Krettli, Dhelio Batista Pereira, Maisa da Silva Araujo, Anna Caroline Campos Aguiar, Paula Miranda Sá

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 150-155 (2021)
International Journal for Parasitology: Drugs and Drug Resistance

Human malaria continues to be a public health problem and an important cause of morbidity and mortality in the world. Malaria control is achieved through both individual protection against mosquito bites and drug treatment, which is hampered by the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ddf88d7088248a4197556cfc82ab38
http://www.sciencedirect.com/science/article/pii/S2211320721000464

Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection

Autor: Jaeson Calla, Elizabeth A. Winzeler, Alyaa Mohamed, Zaira Hellen Villa Galarce, Gregory LaMonte, Annie N. Cowell, Bing Yu Zou, Lawrence T. Wang, Joseph M. Vinetz, Justine Swann, Carlos Tong Rios, Pamela Orjuela-Sánchez, Shangzhong Li, Marta Moreno, Nathan E. Lewis

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature communications, vol 10, iss 1

The exoerythrocytic stage of Plasmodium infection is a critical window for prophylactic intervention. Using genome-wide dual RNA sequencing of flow-sorted infected and uninfected hepatoma cells we show that the human mucosal immunity gene, mucin-13 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ed722df4d47d8dd42a25588671ea21
http://link.springer.com/article/10.1038/s41467-019-08349-0

Developing Plasmodium vivax Resources for Liver Stage Study in the Peruvian Amazon Region

Autor: Brice Campo, Zaira Hellen Villa, Gregory LaMonte, Stephan Meister, Joseph M. Vinetz, Pamela Orjuela-Sánchez, Elizabeth A. Winzeler, Marta Moreno, Carlos Tong-Rios

Publikováno v: ACS Infectious Diseases. 4:531-540

To develop new drugs and vaccines for malaria elimination, it will be necessary to discover biological interventions, including small molecules that act against Plasmodium vivax exoerythrocytic forms. However, a robust in vitro culture system for P.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d68eca6019c865c66fa53b77cc3f18d
https://doi.org/10.1021/acsinfecdis.7b00198