Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Carlos T, Moraes"'
Autor:
Andressa Peres de Oliveira, Claudia D. C. Navarro, Pedro Rafael F. Dias, Tania Arguello, Brittni R. Walker, Sandra R. Bacman, Lizandra Maia Sousa, Roger F. Castilho, Sílvio R. Consonni, Carlos T. Moraes, Jörg Kobarg
Publikováno v:
Proteome Science, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background NEK10, a serine/threonine/tyrosine kinase belonging to the NEK (NIMA-related kinases) family, has been associated with diverse cellular processes. However, no specific target pathways have been identified. Our previous work knocki
Externí odkaz:
https://doaj.org/article/61aca976131e497f9613dfcf146b8532
Autor:
Brittni R Walker, Lise-Michelle Theard, Milena Pinto, Monica Rodriguez-Silva, Sandra R Bacman, Carlos T Moraes
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2210-2232 (2024)
Abstract Oxidative Phosphorylation (OXPHOS) defects can cause severe encephalopathies and no effective treatment exists for these disorders. To assess the ability of gene replacement to prevent disease progression, we subjected two different CNS-defi
Externí odkaz:
https://doaj.org/article/7ee838787fdb4b8a8f0b8075974cedd6
Autor:
Sandra R. Bacman, Jose Domingo Barrera-Paez, Milena Pinto, Derek Van Booven, James B. Stewart, Anthony J. Griswold, Carlos T. Moraes
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102132- (2024)
Mutations within mtDNA frequently give rise to severe encephalopathies. Given that a majority of these mtDNA defects exist in a heteroplasmic state, we harnessed the precision of mitochondrial-targeted TALEN (mitoTALEN) to selectively eliminate mutan
Externí odkaz:
https://doaj.org/article/18fda293f23a4e2c95e8138f074d89c9
Autor:
Christine B. Ryan, James S. Choi, Brian Kang, Seth Herr, Claudia Pereira, Carlos T. Moraes, Hassan Al-Ali, Jae K. Lee
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106370- (2024)
After spinal cord injury (SCI), infiltrating macrophages undergo excessive phagocytosis of myelin and cellular debris, forming lipid-laden foamy macrophages. To understand their role in the cellular pathology of SCI, investigation of the foamy macrop
Externí odkaz:
https://doaj.org/article/cf44ff5fe6334848bb34adf7fffb39dd
Autor:
Ugne Zekonyte, Sandra R. Bacman, Jeff Smith, Wendy Shoop, Claudia V. Pereira, Ginger Tomberlin, James Stewart, Derek Jantz, Carlos T. Moraes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Heteroplasmic mitochondrial DNA mutations lack effective treatments. Here the authors adapt I-CreI meganuclease to target the mitochondria and specifically-eliminate mtDNA with a m.5024C>T mutation in the mttRNA Ala gene.
Externí odkaz:
https://doaj.org/article/e7f6099041724090957f81336f63c028
Autor:
Alessandro Luciani, Anke Schumann, Marine Berquez, Zhiyong Chen, Daniela Nieri, Mario Failli, Huguette Debaix, Beatrice Paola Festa, Natsuko Tokonami, Andrea Raimondi, Alessio Cremonesi, Diego Carrella, Patrick Forny, Stefan Kölker, Francesca Diomedi Camassei, Francisca Diaz, Carlos T. Moraes, Diego Di Bernardo, Matthias R. Baumgartner, Olivier Devuyst
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Methylmalonic acidemia is an inherited metabolic disease caused by loss or mutation of the enzyme MMUT. Here the authors use cell and animal models to show that MMUT mutations lead to defective mitophagy and stress in kidney cells, contributing to th
Externí odkaz:
https://doaj.org/article/234e7b45b1d0490a93784df24510bfa0
Autor:
Claudia V Pereira, Susana Peralta, Tania Arguello, Sandra R Bacman, Francisca Diaz, Carlos T Moraes
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-17 (2020)
Abstract Myopathies are common manifestations of mitochondrial diseases. To investigate whether gene replacement can be used as an effective strategy to treat or cure mitochondrial myopathies, we have generated a complex I conditional knockout mouse
Externí odkaz:
https://doaj.org/article/6c69102eb710425295939e5f7c462f83
Autor:
Brittni R. Walker, Carlos T. Moraes
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 427 (2022)
Mitochondria, the cell’s major energy producers, also act as signaling hubs, interacting with other organelles both directly and indirectly. Despite having its own circular genome, the majority of mitochondrial proteins are encoded by nuclear DNA.
Externí odkaz:
https://doaj.org/article/1b5edaa8969641f982ef4622e7aa40e0
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
Complex I (also known as NADH-ubiquinone oxidoreductase) deficiency is the most frequent mitochondrial disorder present in childhood. NADH-ubiquinone oxidoreductase iron-sulfur protein 3 (NDUFS3) is a catalytic subunit of the mitochondrial complex I;
Externí odkaz:
https://doaj.org/article/bc79422302af4239856dcec7ae4756cf
Autor:
Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-11 (2018)
Abstract Pathogenic mitochondrial DNA (mtDNA) mutations often co‐exist with wild‐type molecules (mtDNA heteroplasmy). Phenotypes manifest when the percentage of mutant mtDNA is high (70–90%). Previously, our laboratory showed that mitochondria
Externí odkaz:
https://doaj.org/article/7a381d0d4b6e4d0eb16577d5be175b52