Comparative Analysis of the Physicochemical and Biological Characteristics of Freeze-Dried PEGylated Cationic Solid Lipid Nanoparticles

Autor: David A. Narváez-Narváez, María Duarte-Ruiz, Sandra Jiménez-Lozano, Cristina Moreno-Castro, Ronny Vargas, Anna Nardi-Ricart, Encarna García-Montoya, Pilar Pérez-Lozano, Josep Mª Suñé-Negre, Cristina Hernández-Munain, Carlos Suñé, Marc Suñé-Pou

Publikováno v: Pharmaceuticals, Vol 16, Iss 11, p 1583 (2023)

Cationic solid-lipid nanoparticles (cSLNs) have become a promising tool for gene and RNA therapies. PEGylation (PEG) is crucial in enhancing particle stability and protection. We evaluated the impact of PEG on the physicochemical and biological chara

Externí odkaz: https://doaj.org/article/6d61431077e54d538826a4b5650aea07

Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease

Autor: Marc Suñé-Pou, María J. Limeres, Cristina Moreno-Castro, Cristina Hernández-Munain, Josep M. Suñé-Negre, María L. Cuestas, Carlos Suñé

Publikováno v: Frontiers in Genetics, Vol 11 (2020)

Alternative splicing of pre-mRNA contributes strongly to the diversity of cell- and tissue-specific protein expression patterns. Global transcriptome analyses have suggested that >90% of human multiexon genes are alternatively spliced. Alterations in

Externí odkaz: https://doaj.org/article/24b50357724844d5b9421be20eb53e2a

Functional Consequences for Apoptosis by Transcription Elongation Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative Splicing.

Autor: Marta Montes, Mayte Coiras, Soraya Becerra, Cristina Moreno-Castro, Elena Mateos, Jara Majuelos, F Javier Oliver, Cristina Hernández-Munain, José Alcamí, Carlos Suñé

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0139812 (2015)

Here, we present evidence for a specific role of the splicing-related factor TCERG1 in regulating apoptosis in live cells by modulating the alternative splicing of the apoptotic genes Bcl-x and Fas. We show that TCERG1 modulates Bcl-x alternative spl

Externí odkaz: https://doaj.org/article/df90d38a9abd498fb5a7a8f4d76f1230

Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease

Autor: María Luján Cuestas, Cristina Hernández-Munain, Cristina Moreno-Castro, Marc Suñé-Pou, Josep M. Suñé-Negre, Carlos Suñé, María J. Limeres

Publikováno v: Frontiers in Genetics, Vol 11 (2020)
Dipòsit Digital de la UB
Universidad de Barcelona
Frontiers in Genetics
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Alternative splicing of pre-mRNA contributes strongly to the diversity of cell- and tissue-specific protein expression patterns. Global transcriptome analyses have suggested that >90% of human multiexon genes are alternatively spliced. Alterations in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f537e671ab99cd918b49e537a4ac7dc6
https://www.frontiersin.org/article/10.3389/fgene.2020.00731/full

Improved formulation of cationic solid lipid nanoparticles displays cellular uptake and biological activity of nucleic acids

Autor: Cristina Hernández-Munain, Pilar Pérez-Lozano, Josep Mª Suñé-Negre, Encarna García-Montoya, Marc Suñé-Pou, Sofía Boyero-Corral, Josep R. Ticó, Anna Fàbregas, Montserrat Miñarro, Carlos Suñé, Silvia Prieto-Sánchez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Non-viral delivery using cationic solid lipid nanoparticles (SLNs) represents a useful strategy to introduce large DNA and RNA molecules to target cells. A careful selection of components and their amounts is critical to improve transfection efficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4525c8b49c69d5e09bda77f10dbc17
https://doi.org/10.1016/j.ijpharm.2016.11.026