Dynamics of a hippocampal neuronal ensemble encoding trace fear memory revealed by in vivo Ca2+ imaging.

Autor: Liang Zhang, Xuanmao Chen, Carlos Sindreu, Song Lu, Daniel R Storm, Larry S Zweifel, Zhengui Xia

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0219152 (2019)

Although the biochemical signaling events in area CA1 of the hippocampus underlying memory acquisition, consolidation, retrieval, and extinction have been extensively studied, little is known about the activity dynamics of hippocampal neurons in CA1

Externí odkaz: https://doaj.org/article/a06294cfd0934455aea2627b9345c0df

Synaptic proteomics as a means to identify the molecular basis of mental illness: Are we getting there?

Autor: Àlex Bayés, Rita Reig-Viader, Carlos Sindreu

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 84:353-361

Synapses are centrally involved in many brain disorders, particularly in psychiatric and neurodevelopmental ones. However, our current understanding of the proteomic alterations affecting synaptic performance in the majority of mental illnesses is li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260ac97eac58a3f485e06726379075aa
https://doi.org/10.1016/j.pnpbp.2017.09.011

Septal GABAergic Inputs to CA1 Govern Contextual Memory Retrieval

Autor: Srinidhi Desikan, Arnau Sans-Dublanc, Jaime de la Rocha, Marta Pascual, Adria Razzauti, Hannah Monyer, Carlos Sindreu

Whether projections from the medial septum regulate the function of the CA1 hippocampus in episodic memory retrieval is not known. Here we show that septal GABAergic inputs to CA1 promote contextual fear memory, blocking the activation of parvalbumin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c83300ed103d4bcaa79b870a72ca85

l -Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B -related pediatric encephalopathy

Autor: Roberto García-Díaz, Benoit Colsch, Mireia Olivella, Francisco Ciruela, Sílvia Locubiche, Macarena Gómez de Salazar, Àlex Bayés, Anna López-Sala, Xavier Altafaj, Esther Gratacòs-Batlle, Ana Santos-Gómez, Xavier Gasull, Angels García-Cazorla, Víctor Fernández-Dueñas, David Ramos-Vicente, Judith Armstrong, Clara Alcon, Emeline Chu-Van, Carlos Sindreu, Cristina Grau, David Soto

Publikováno v: Science Signaling
Science Signaling, American Association for the Advancement of Science (AAAS), 2019, 12 (586), ⟨10.1126/scisignal.aaw0936⟩
Science Signaling, American Association for the Advancement of Science, 2019, 12 (586), ⟨10.1126/scisignal.aaw0936⟩

International audience; Autosomal dominant mutations in GRIN2B are associated with severe encephalopathy, but little is known about the pathophysiological outcomes and any potential therapeutic interventions. Genetic studies have described the associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a485530372c1d7b5d759129f75ae94
https://doi.org/10.1126/scisignal.aaw0936

Dynamics of a hippocampal neuronal ensemble encoding trace fear memory revealed by in vivo Ca2+ imaging

Autor: Song Lu, Xuanmao Chen, Carlos Sindreu, Zhengui Xia, Larry S. Zweifel, Daniel R. Storm, Liang Zhang

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0219152 (2019)
PLoS ONE

Although the biochemical signaling events in area CA1 of the hippocampus underlying memory acquisition, consolidation, retrieval, and extinction have been extensively studied, little is known about the activity dynamics of hippocampal neurons in CA1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fc7c6764c1aa9f26373b2df0d3e163
https://doi.org/10.1371/journal.pone.0219152