Výsledky vyhledávání - "Carlos R. Lazo"

Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease

Autor: Yoland Smith, Ethel C. Garnier-Amblard, Gary W. Miller, Lauren P. Shapiro, Carlos R. Lazo, Stephen F. Traynelis, Stefka Gyoneva

Publikováno v: Neurobiology of Disease, Vol 67, Iss, Pp 191-202 (2014)

Microglia, the immune cells of the central nervous system, constantly survey the parenchyma in the healthy brain to maintain homeostasis. When a disturbance, such as cell death, results in ATP release in vivo , microglial processes respond by utilizi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3867c7950847dcf521db0ca3b06beaed
http://www.sciencedirect.com/science/article/pii/S0969996114000655

Zobrazit plný text záznamu

Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo

Autor: Xueliang Fan, Alison I. Bernstein, Gary W. Miller, Yingjie Li, Kristen A. Stout, Thomas S. Guillot, Minzheng Wang, Laura M. Vecchio, Carlos R. Lazo, Ellen J. Hess, Shawn P. Alter, Amy R. Dunn, Hong Yi, Kelly M. Lohr, Ali Salahpour, David S. Goldstein

Publikováno v: Proceedings of the National Academy of Sciences. 111:9977-9982

Disruption of neurotransmitter vesicle dynamics (transport, capacity, release) has been implicated in a variety of neurodegenerative and neuropsychiatric conditions. Here, we report a novel mouse model of enhanced vesicular function via bacterial art

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d58606a97f813ba69f2953719dad8d
https://doi.org/10.1073/pnas.1402134111

Zobrazit plný text záznamu

RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells

Autor: Elaine L. Pranski, Nirjari V. Dalal, Allan I. Levey, Marla Gearing, Gary W. Miller, Ranjita Betarbet, James J. Lah, Jeremy H. Herskowitz, Carson D. Van Sanford, Carlos R. Lazo

Publikováno v: Neurobiology of Disease, Vol 54, Iss, Pp 264-279 (2013)

Chronic activation of the NF-κB pathway is associated with progressive neurodegeneration in Parkinson's disease (PD). Given the role of neuronal RING finger protein 11 (RNF11) as a negative regulator of the NF-κB pathway, in this report we investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43fb8e499532b0380c01927c09304f7
http://www.sciencedirect.com/science/article/pii/S0969996113000090

Zobrazit plný text záznamu

Exposure to the polybrominated diphenyl ether mixture DE-71 damages the nigrostriatal dopamine system: Role of dopamine handling in neurotoxicity

Autor: Hye Mi Kim, Kristen A. Stout, Gary W. Miller, Douglas I. Walker, W. Wyatt Wilson, W. Michael Caudle, Joshua M. Bradner, Tiffany A. Suragh, Min Z. Wang, Carlos R. Lazo, Kurt D. Pennell, Jason R. Richardson

Publikováno v: Experimental Neurology. 241:138-147

In the last several decades polybrominated diphenyl ethers (PBDEs) have replaced the previously banned polychlorinated biphenyls (PCBs) in multiple flame retardant utilities. As epidemiological and laboratory studies have suggested PCBs as a risk fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f11135e0418c8aa97a22a223263585
https://doi.org/10.1016/j.expneurol.2012.12.013

Zobrazit plný text záznamu

Parkinson's disease and the environment: beyond pesticides

Autor: Carlos R. Lazo, Gary W. Miller, W. Michael Caudle, Thomas S. Guillot

Publikováno v: Neurotoxicology. 33(3)

The exposure of the human population to environmental contaminants is recognized as a significant contributing factor for the development of Parkinson’s disease (PD) and other forms of parkinsonism. While pesticides have repeatedly been identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26695ad790fd996a8bf66e0ff6f06b9
https://pubmed.ncbi.nlm.nih.gov/22309908

Zobrazit plný text záznamu

Traumatic brain injury in adult rats causes progressive nigrostriatal dopaminergic cell loss and enhanced vulnerability to the pesticide paraquat

Autor: David A. Hovda, Carlos R. Lazo, Farzad Mortazavi, Christopher C. Giza, Marie-Françoise Chesselet, C.B. Hutson

Publikováno v: Journal of neurotrauma. 28(9)

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of nigrostriatal dopaminergic neurons and the accumulation of alpha-synuclein. Both traumatic brain injury (TBI) and pesticides are risk factors for PD, but whether TB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f58f3f655916299d57417ac23b2e1fd
https://pubmed.ncbi.nlm.nih.gov/21644813

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání