Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Carlos R. Gil Del Alcazar"'
Autor:
Maša Alečković, Simona Cristea, Carlos R. Gil Del Alcazar, Pengze Yan, Lina Ding, Ethan D. Krop, Nicholas W. Harper, Ernesto Rojas Jimenez, Donghao Lu, Anushree C. Gulvady, Pierre Foidart, Marco Seehawer, Benedetto Diciaccio, Katherine C. Murphy, Jason Pyrdol, Jayati Anand, Kodie Garza, Kai W. Wucherpfennig, Rulla M. Tamimi, Franziska Michor, Kornelia Polyak
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
TGFβ signalling is reported to regulate hormone-responsive mammary epithelial progenitors that are associated with breast cancer risk. Here, the authors find that short-term TGFBR1 inhibition prevents tumour formation in rat breast cancer models and
Externí odkaz:
https://doaj.org/article/1cad67a83e124a70947f561786bfe0e4
Autor:
Kornelia Polyak, Senthil K. Muthuswamy, Deborah A. Dillon, Gordon J. Freeman, Sara M. Tolaney, Eliezer M. Van Allen, Tanya E. Keenan, Katherine C. Murphy, Bethlehem Lulseged, Ethan D. Krop, Shanshan Xie, Michael U.J. Oliphant, Nicholas W. Harper, Ernesto Rojas Jimenez, Maša Alečković, Anne Trinh, Carlos R. Gil Del Alcazar
Supplementary Figure from Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3e63f003b1e1eafb910ef2ba844d94
https://doi.org/10.1158/2326-6066.22544781
https://doi.org/10.1158/2326-6066.22544781
Autor:
Kornelia Polyak, Senthil K. Muthuswamy, Deborah A. Dillon, Gordon J. Freeman, Sara M. Tolaney, Eliezer M. Van Allen, Tanya E. Keenan, Katherine C. Murphy, Bethlehem Lulseged, Ethan D. Krop, Shanshan Xie, Michael U.J. Oliphant, Nicholas W. Harper, Ernesto Rojas Jimenez, Maša Alečković, Anne Trinh, Carlos R. Gil Del Alcazar
Animal models are critical for the preclinical validation of cancer immunotherapies. Unfortunately, mouse breast cancer models do not faithfully reproduce the molecular subtypes and immune environment of the human disease. In particular, there are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c53be361367e588cf66a62c9dd98b28
https://doi.org/10.1158/2326-6066.c.6550743
https://doi.org/10.1158/2326-6066.c.6550743
Autor:
Kornelia Polyak, Senthil K. Muthuswamy, Deborah A. Dillon, Gordon J. Freeman, Sara M. Tolaney, Eliezer M. Van Allen, Tanya E. Keenan, Katherine C. Murphy, Bethlehem Lulseged, Ethan D. Krop, Shanshan Xie, Michael U.J. Oliphant, Nicholas W. Harper, Ernesto Rojas Jimenez, Maša Alečković, Anne Trinh, Carlos R. Gil Del Alcazar
Supplementary Table from Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c9b07e181291f79292007acc15d6e1
https://doi.org/10.1158/2326-6066.22544772.v1
https://doi.org/10.1158/2326-6066.22544772.v1
Autor:
Kornelia Polyak, Joe Gray, Catherine Wu, Joon Jeong, So Yeon Park, C. Marcelo Aldaz, Bojana Jovanović, Jennifer Eng, Guillaume Thibault, Young Hwan Chang, Koei Chin, Sachet A. Shukla, Carlos R. Gil Del Alcazar, Anne Trinh
S1. Overview of patient cohort. S2. Whole exome sequencing of matched DCISand IDC transition. S3. Mutationalprofiling of the DCIS-to-IDC transition. S4.Phenotypic immune properties of patient cohort. S5.Immune-related genomicchanges and neoantigen lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7edba2c92e3ebffa2d8110c7b4f0c5
https://doi.org/10.1158/1541-7786.22526628.v1
https://doi.org/10.1158/1541-7786.22526628.v1
Autor:
Kornelia Polyak, Franziska Michor, So Yeon Park, Joon Jeong, D. Craig Allred, Kristie Bobolis, Rong Fan, Judy E. Garber, Lisa M. Coussens, Therese Sorlie, Deborah Dillon, Gordon J. Freeman, Ron Rowberry, Jon Wagner, Charles H. McDonnell, Elizabeth Min Hui Kim, Kirsten Babski, Andrea L. Richardson, Hege G. Russnes, Lina Ding, Ying Su, Helga Bergholtz, Minsuk Kwak, Xiaoyuan Zi, Francisco Beca, Lin L. Liu, Anne Trinh, Muhammad B. Ekram, Sung Jin Huh, Carlos R. Gil Del Alcazar
Supplementary Figure S1. Leukocyte frequencies in breast tissues. Supplementary Figure S2. Genes expressed in T cells. Supplementary Figure S3. Activity status of T cells. Supplementary Figure S4. TCR clonotypes in breast tissues. Supplementary Figur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4dbf5a64431466b58c0e00a5b286dd
https://doi.org/10.1158/2159-8290.22531790
https://doi.org/10.1158/2159-8290.22531790
Autor:
Kornelia Polyak, Joe Gray, Catherine Wu, Joon Jeong, So Yeon Park, C. Marcelo Aldaz, Bojana Jovanović, Jennifer Eng, Guillaume Thibault, Young Hwan Chang, Koei Chin, Sachet A. Shukla, Carlos R. Gil Del Alcazar, Anne Trinh
The drivers of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) transition are poorly understood. Here, we conducted an integrated genomic, transcriptomic, and whole-slide image analysis to evaluate changes in copy-number profiles,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4043beefe3b68d4bdf3955b02befc6cc
https://doi.org/10.1158/1541-7786.c.6545157.v1
https://doi.org/10.1158/1541-7786.c.6545157.v1
Autor:
Kornelia Polyak, Franziska Michor, So Yeon Park, Joon Jeong, D. Craig Allred, Kristie Bobolis, Rong Fan, Judy E. Garber, Lisa M. Coussens, Therese Sorlie, Deborah Dillon, Gordon J. Freeman, Ron Rowberry, Jon Wagner, Charles H. McDonnell, Elizabeth Min Hui Kim, Kirsten Babski, Andrea L. Richardson, Hege G. Russnes, Lina Ding, Ying Su, Helga Bergholtz, Minsuk Kwak, Xiaoyuan Zi, Francisco Beca, Lin L. Liu, Anne Trinh, Muhammad B. Ekram, Sung Jin Huh, Carlos R. Gil Del Alcazar
Supplementary Table S1. List of tissue samples used. Supplementary Table S2. Raw FACS data in each sample. Supplementary Table S3. List of differentially expressed genes. Supplementary Table S4. Results of GSEA analyses. Supplementary Table S5. Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8019566157c56da010a1fc1ade4031e9
https://doi.org/10.1158/2159-8290.22531784
https://doi.org/10.1158/2159-8290.22531784
Autor:
Kornelia Polyak, Joe Gray, Catherine Wu, Joon Jeong, So Yeon Park, C. Marcelo Aldaz, Bojana Jovanović, Jennifer Eng, Guillaume Thibault, Young Hwan Chang, Koei Chin, Sachet A. Shukla, Carlos R. Gil Del Alcazar, Anne Trinh
Summary of Supplementary Tables Supplementary Table S1. Clinicopathological characteristics of patient cohort Supplementary Table S2. Antibody panel for cyclic IF Supplementary Table S3. Summary of mutations and neoantigen expression in the recurrenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8219f4c5adf6583a5ab90bb7c999c7a1
https://doi.org/10.1158/1541-7786.22526625.v1
https://doi.org/10.1158/1541-7786.22526625.v1
Autor:
Carlos R. Gil Del Alcazar, Anne Trinh, Maša Alečković, Ernesto Rojas Jimenez, Nicholas W. Harper, Michael U.J. Oliphant, Shanshan Xie, Ethan D. Krop, Bethlehem Lulseged, Katherine C. Murphy, Tanya E. Keenan, Eliezer M. Van Allen, Sara M. Tolaney, Gordon J. Freeman, Deborah A. Dillon, Senthil K. Muthuswamy, Kornelia Polyak
Publikováno v:
Cancer Immunol Res
Animal models are critical for the preclinical validation of cancer immunotherapies. Unfortunately, mouse breast cancer models do not faithfully reproduce the molecular subtypes and immune environment of the human disease. In particular, there are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8831c6269935f7802d25316936319a86
https://europepmc.org/articles/PMC9177779/
https://europepmc.org/articles/PMC9177779/