Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Carlos R Machado"'
Autor:
Grazielle R Goes, Peter S Rocha, Aline R S Diniz, Pedro H N Aguiar, Carlos R Machado, Leda Q Vieira
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004555 (2016)
BACKGROUND:During Trypanosoma cruzi infection, macrophages produce reactive oxygen species (ROS) in a process called respiratory burst. Several works have aimed to elucidate the role of ROS during T. cruzi infection and the results obtained are somet
Externí odkaz:
https://doaj.org/article/778e1d58502148d49ac1cc9eb1798525
Autor:
Viviane Grazielle-Silva, Tehseen Fatima Zeb, Jason Bolderson, Priscila C Campos, Julia B Miranda, Ceres L Alves, Carlos R Machado, Richard McCulloch, Santuza M R Teixeira
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003870 (2015)
BACKGROUND:DNA repair mechanisms are crucial for maintenance of the genome in all organisms, including parasites where successful infection is dependent both on genomic stability and sequence variation. MSH2 is an early acting, central component of t
Externí odkaz:
https://doaj.org/article/bb5b7def7a3c4fb4abd4675659eae563
Autor:
Pedro HN de Aguiar, Débora N Santos, Francisco P Lobo, Túlio M Santos, Andréa M Macedo, Sérgio DJ Pena, Carlos R Machado, Glória R Franco
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 101, Pp 323-326 (2006)
In a previous study, the Schistosoma mansoni Rho1 protein was able to complement Rho1 null mutant Saccharomyces cerevisiae cells at restrictive temperatures and under osmotic stress (low calcium concentration) better than the human homologue (RhoA).
Externí odkaz:
https://doaj.org/article/dcfed521886f4b1f8766da6076e23f5d
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 99, Iss 1, Pp 1-12 (2004)
Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes.
Externí odkaz:
https://doaj.org/article/cbfe484e58c54a89af8a6876e1d05468
Autor:
Pedro H N Aguiar, Carolina Furtado, Bruno M Repolês, Grazielle A Ribeiro, Isabela C Mendes, Eduardo F Peloso, Fernanda R Gadelha, Andrea M Macedo, Glória R Franco, Sérgio D J Pena, Santuza M R Teixeira, Leda Q Vieira, Alessandra A Guarneri, Luciana O Andrade, Carlos R Machado
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 6, p e2279 (2013)
The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-o
Externí odkaz:
https://doaj.org/article/c3030a2328674338ab1d1c9ce0656a09
Autor:
Francisco P Lobo, Bruno E F Mota, Sérgio D J Pena, Vasco Azevedo, Andréa M Macedo, Andreas Tauch, Carlos R Machado, Glória R Franco
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6282 (2009)
Virus-host biological interaction is a continuous coevolutionary process involving both host immune system and viral escape mechanisms. Flaviviridae family is composed of fast evolving RNA viruses that infects vertebrate (mammals and birds) and/or in
Externí odkaz:
https://doaj.org/article/61056faf1e5d4f49962852a3d8bac344
Autor:
Jorge M Freitas, Luciana O Andrade, Simone F Pires, Ricardo Lima, Egler Chiari, Ricardo R Santos, Milena Soares, Carlos R Machado, Gloria R Franco, Sergio D J Pena, Andrea M Macedo
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5113 (2009)
We have previously demonstrated that both parasite genetic variability and host genetic background were important in determining the differential tissue distribution of the Col1.7G2 and JG T. cruzi monoclonal strains after artificial infections in mi
Externí odkaz:
https://doaj.org/article/f37398b19dfe459a97b4b454a8523fe9
Autor:
Marcela G Drummond, Carlos E Calzavara-Silva, Diego S D'Astolfo, Fernanda C Cardoso, Matheus A Rajão, Marina M Mourão, Elisandra Gava, Sérgio C Oliveira, Andréa M Macedo, Carlos R Machado, Sérgio D J Pena, Gregory T Kitten, Glória R Franco
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 11, p e547 (2009)
BACKGROUND: During its development, the parasite Schistosoma mansoni is exposed to different environments and undergoes many morphological and physiological transformations as a result of profound changes in gene expression. Characterization of prote
Externí odkaz:
https://doaj.org/article/8cc3acc5733d489abdbabc3ddf308149
Publikováno v:
Bio Protoc
Trypanosoma cruzi is a protozoan parasite belonging to the Trypanosomatidae family. Although the trypanosomatids multiply predominantly by clonal generation, the presence of DNA exchange in some of them has been puzzling researchers over the years, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b940b50eb37d1c8be4fa4bd174b2b88
https://pubmed.ncbi.nlm.nih.gov/34532563
https://pubmed.ncbi.nlm.nih.gov/34532563
Autor:
Carlos R, Machado, João P, Vieira-da-Rocha, Isabela Cecilia, Mendes, Matheus A, Rajão, Lucio, Marcello, Mainá, Bitar, Marcela G, Drummond, Priscila, Grynberg, Denise A A, Oliveira, Catarina, Marques, Ben, Van Houten, Richard, McCulloch
Publikováno v:
Molecular Microbiology
Nucleotide excision repair (NER) is a highly conserved genome repair pathway acting on helix distorting DNA lesions. NER is divided into two subpathways: global genome NER (GG-NER), which is responsible for repair throughout genomes, and transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff5458b70d194acd3ef055e84b41465f
https://pubmed.ncbi.nlm.nih.gov/24661334
https://pubmed.ncbi.nlm.nih.gov/24661334