Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Carlos R, Rodrigues"'
Autor:
Pedro Henrique R. de A. Azevedo, Priscila G. Camargo, Larissa E. C. Constant, Stephany da S. Costa, Celimar Sinézia Silva, Alice S. Rosa, Daniel D. C. Souza, Amanda R. Tucci, Vivian N. S. Ferreira, Thamara Kelcya F. Oliveira, Nathalia R. R. Borba, Carlos R. Rodrigues, Magaly G. Albuquerque, Luiza R. S. Dias, Rafael Garrett, Milene D. Miranda, Diego Allonso, Camilo Henrique da S. Lima, Estela Maris F. Muri
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract COVID-19 is a multisystemic disease caused by the SARS-CoV-2 airborne virus, a member of the Coronaviridae family. It has a positive sense single-stranded RNA genome and encodes two non-structural proteins through viral cysteine-proteases pr
Externí odkaz:
https://doaj.org/article/e01b592981ca41dcbf917ad582e8025a
Autor:
MARCELE C.C. DA SILVA, LETÍCIA C.L. DE ABREU, FLAVIA A. DO CARMO, CARLOS R. RODRIGUES, VALERIA P. DE SOUSA, LUCIO M. CABRAL
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 94, Iss suppl 3 (2022)
Abstract The concern about the risks of viral infections transmission through blood transfusion has led into a search for improvements on screening tests used for the selection of blood donors. Molecular biology techniques applied in researches of vi
Externí odkaz:
https://doaj.org/article/03923ba69e424d1fbb0ebf94f569217b
Autor:
JÉSSICA B. DE JESUS, RAISSA A. DA CONCEIÇÃO, THAYNÁ R. MACHADO, MARIA L.C. BARBOSA, THAISA F.S. DOMINGOS, LUCIO M. CABRAL, CARLOS R. RODRIGUES, BÁRBARA ABRAHIM-VIEIRA, ALESSANDRA M.T. DE SOUZA
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 94, Iss suppl 3 (2022)
Abstract Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are the latest class of drugs approved to treat type 2 DM (T2DM). Although adverse effects are often caused by a metabolite rather than the drug itself, only the safety assessment of disprop
Externí odkaz:
https://doaj.org/article/d7315ccc43f24e79baf2d5d9959383c4
Autor:
BARBÁRA A. ABRAHIM-VIEIRA, ALESSANDRA M.T. DE SOUZA, RITA C. BARROS, FLÁVIA A. DO CARMO, LETÍCIA C.L. DE ABREU, RONYSON S.S. MOREIRA, THIAGO S. HONÓRIO, CARLOS R. RODRIGUES, VALERIA P. DE SOUSA, LUCIO M. CABRAL
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 92, Iss 2 (2020)
Abstract Sildenafil is a potent selective inhibitor of phosphosdiesterase-5 previously used in erectile dysfunction and subsequently approved in 2005 for pulmonary arterial hypertension treatment. Since oral administration of sildenafil shows pharmac
Externí odkaz:
https://doaj.org/article/3ebcc8a015384daaaf5f73f18af76622
Autor:
Daniel T. G. Gonzaga, Felipe H. Oliveira, N. L. von Ranke, G. Q. Pinho, Juliana P. Salles, Murilo L. Bello, Carlos R. Rodrigues, Helena C. Castro, Hellen V. C. M. de Souza, Caroline R. C. Reis, Rennan P. P. Leme, João C. M. Mafra, Luiz C. S. Pinheiro, Lucas V. B. Hoelz, Nubia Boechat, Robson X. Faria
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Twenty new 2-(1H-pyrazol-1-yl)-1,3,4-thiadiazole analogs were synthetized to develop P2X7 receptor (P2X7R) inhibitors. P2X7R inhibition in vitro was evaluated in mouse peritoneal macrophages, HEK-293 cells transfected with hP2X7R (dye uptake assay),
Externí odkaz:
https://doaj.org/article/9ab312f8957145ae9c80d75e8662765a
Autor:
Juliana F. R. Mello, Nathália C. Botelho, Alessandra M. T. Souza, Riethe Oliveira, Monique A. Brito, Bárbara de A. Abrahim-Vieira, Ana Carolina R. Sodero, Helena C. Castro, Lucio M. Cabral, Leonardo A. Miceli, Carlos R. Rodrigues
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 10689-10704 (2015)
Herpes simplex virus infections have been described in the medical literature for centuries, yet the the drugs available nowadays for therapy are largely ineffective and low oral bioavailability plays an important role on the inefficacy of the treatm
Externí odkaz:
https://doaj.org/article/4c44b936310b4d6fb14b26f34c18c6d2
This paper presents a discussion on Enactive Artificial Intelligence about the practical evolution of this field. It has been mostly discussed theoretically, but few are the works that try to implement it. In 2009 were published two paradigmatic work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77364fff7ce23c50f254540b57619791
https://doi.org/10.21203/rs.3.rs-2251292/v1
https://doi.org/10.21203/rs.3.rs-2251292/v1
Autor:
Thayná R. Machado, Letícia V. Faro, Angélica L.do Nascimento Mello, David de O. Silva, Bárbara de A. Abrahim-Vieira, Carlos R. Rodrigues, Rita Hemanuelle S. Silva, Claudio S.Viana Junior, Mauro Sola-Penna, Fernanda da C.S. Boechat, Marcos C. de Souza, Patricia Zancan, Maria Cecília B.V. de Souza, Alessandra M.T. de Souza
Publikováno v:
Journal of Molecular Structure. 1276:134542
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ccaa29539fbfd8e6e43ce0f7bcb5d90
https://doi.org/10.1016/j.molstruc.2022.134542
https://doi.org/10.1016/j.molstruc.2022.134542
Autor:
Alessandra M. T. de Souza, Monique A. de Brito, Lucio M. Cabral, Magaly G. Albuquerque, Juliana F. R. Mello, Carlos R. Rodrigues, Helena C. Castro, Valéria L. Teixeira, Leonardo A. Miceli
Publikováno v:
Marine Drugs, Vol 11, Iss 11, Pp 4127-4143 (2013)
AIDS is a pandemic responsible for more than 35 million deaths. The emergence of resistant mutations due to drug use is the biggest cause of treatment failure. Marine organisms are sources of different molecules, some of which offer promising HIV-1 r
Externí odkaz:
https://doaj.org/article/c442a40fee734ba7bf5ad88d16760c9b
Autor:
Carlos R. Rodrigues, Bruno Leal, Kely N. De Oliveira, Ariane S. S. R. Ferreira, Alice Bernardino, Ricardo J. Nunes, Vitor Ferreira, Maria C. De Souza, Anna C. Cunha, Helena C. Castro
Publikováno v:
Journal of Systemics, Cybernetics and Informatics, Vol 11, Iss 3, Pp 62-65 (2013)
The emergence of multidrug-resistant bacterial strains is a world problem that increases the need for new and more effective antimicrobials. On that purpose, derivatives of cyclic systems may serve as new leads for discovering new active molecules. I
Externí odkaz:
https://doaj.org/article/16b1e6a9030147aaa2d24e34a22bad21