Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Carlos Perez-Stable"'
Publikováno v:
PeerJ, Vol 1, p e144 (2013)
Castration-resistant prostate cancer (CRPC) expresses high levels of the anti-apoptotic proteins Bcl-2, Bcl-xL and Mcl-1, resulting in resistance to apoptosis and association with poor prognosis. Docetaxel, an antimitotic drug that is the first-line
Externí odkaz:
https://doaj.org/article/e9900c02c7694390852beec45f123d5a
Autor:
Dominick G A Burton, Maria G Giribaldi, Anisleidys Munoz, Katherine Halvorsen, Asmita Patel, Merce Jorda, Carlos Perez-Stable, Priyamvada Rai
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68003 (2013)
Androgen deprivation (AD) is an effective method for initially suppressing prostate cancer (PC) progression. However, androgen-refractory PC cells inevitably emerge from the androgen-responsive tumor, leading to incurable disease. Recent studies have
Externí odkaz:
https://doaj.org/article/e8c108d649c24e299fff0ac2f2a92555
Autor:
Teresita Reiner, Ricardo Parrondo, Alicia de Las Pozas, Deanna Palenzuela, Carlos Perez-Stable
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56234 (2013)
Inhibition of the ubiquitin-proteasome system (UPS) of protein degradation is a valid anti-cancer strategy and has led to the approval of bortezomib for the treatment of multiple myeloma. However, the alternative approach of enhancing the degradation
Externí odkaz:
https://doaj.org/article/795885cb68f6470d90c2741e1022e824
Autor:
Meghan A. Rice, Kerry L. Burnstein, Travis Yates, P Miller, Priyamvada Rai, Derek M. Dykxhoorn, Thirupandiyur S. Udayakumar, Fiorella Magani, Reema A. Ishteiwy, Teresita Reiner, Ramiro E. Verdun, Carlos Perez-Stable
Publikováno v:
Oncogene. 35:4752-4761
Deregulation of microRNAs (miRs) contributes to progression and metastasis of prostate and other cancers. miR-23b and -27b, encoded in the same miR cluster (miR-23b/-27b), are downregulated in human metastatic prostate cancer compared with primary tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c1c3c0bfe05363066a9735eca2b820
https://doi.org/10.1038/onc.2016.6
https://doi.org/10.1038/onc.2016.6
Autor:
Deanna Palenzuela, Priyamvada Rai, Teresita Reiner, Ricardo Parrondo, Carlos Perez-Stable, Alicia de las Pozas, William Cayuso
Publikováno v:
Oncoscience
The anti-apoptotic protein Mcl-1 is highly expressed in castration-resistant prostate cancer (CRPC), resulting in resistance to apoptosis and association with poor prognosis. Although predominantly localized in the cytoplasm, there is evidence that M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725632871b960f0d5334ae8c11b714b5
https://doi.org/10.18632/oncoscience.231
https://doi.org/10.18632/oncoscience.231
Autor:
Carlos Perez-Stable, Virginia De Cesare, Teresita Reiner, Matthias Trost, Alicia de las Pozas
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Prostate cancer (PCa), a leading cause of cancer-related death in men, becomes resistant to androgen deprivation therapy by inducing androgen receptor (AR) activity, which is known as castration-resistant PCa (CRPC). Enzalutamide is an approved drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3609ea8e7780e645da01298791a0927d
https://pubmed.ncbi.nlm.nih.gov/30177856
https://pubmed.ncbi.nlm.nih.gov/30177856
Autor:
Carlos Perez-Stable, Asmita Patel, Alexander Cohen, Wayne Balkan, Priyamvada Rai, Maria G. Giribaldi, Samer Singh, Dominick G. A. Burton, Dao M. Nguyen, David J. Robbins, Anisleidys Munoz, Teresita Reiner, Katherine Halvorsen
Publikováno v:
Oncogene
Oncogenic RAS promotes production of reactive oxygen species (ROS), which mediate pro-malignant signaling but can also trigger DNA damage-induced tumor suppression. Thus RAS-driven tumor cells require redox-protective mechanisms to mitigate the damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bf63d447b718ad4854955f56c95e69
https://doi.org/10.1038/onc.2014.195
https://doi.org/10.1038/onc.2014.195
Autor:
Miriam Redrado, Carlos Perez-Stable, Ricardo Parrondo, Roque Diaz, Alfonso Calvo, Irene Manrique, Paul Nguewa
Publikováno v:
ResearcherID
Id-1 is a member of the helix-loop-helix family of proteins that regulates the activity of transcription factors to suppress cellular differentiation and to promote cell growth. Overexpression of Id-1 in tumor cells correlates with increased malignan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b815b528bd0e3b07bab1f9165b9afbf
https://doi.org/10.2174/1566524013666131203100643
https://doi.org/10.2174/1566524013666131203100643
Autor:
Carmen Rios, Megan E. Rieger, Gaëtan J.-R. Delcroix, Guy A. Howard, Jimmy El Hokayem, Paul C. Schiller, Kevin M. Curtis, Carlos Perez-Stable, Ricardo Parrondo, Lourdes A. Gomez, Alicia de las Pozas, Gianluca D'Ippolito
Publikováno v:
Stem cells and development. 25(11)
Human bone marrow multipotent mesenchymal stromal cell (hMSC) number decreases with aging. Subpopulations of hMSCs can differentiate into cells found in bone, vasculature, cartilage, gut, and other tissues and participate in their repair. Maintaining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a219b43efe161c810063ea3dbd8315
https://pubmed.ncbi.nlm.nih.gov/27059084
https://pubmed.ncbi.nlm.nih.gov/27059084
Autor:
Guy A. Howard, Paul C. Schiller, Carlos Perez-Stable, Bernard A. Roos, Ketian Chen, Gianluca D'Ippolito
Publikováno v:
Bone. 49:1194-1204
Human bone marrow-derived stem cells (hMSCs) are a major source of osteoprogenitors. Hepatocyte growth factor (HGF), a glycoprotein constitutively produced by hMSCs, is reported to act on differentiated osteoblasts and also osteoclasts. Moreover, HGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9aa2291a1a1dee7bb8c5b3363c21fd
https://doi.org/10.1016/j.bone.2011.08.023
https://doi.org/10.1016/j.bone.2011.08.023