Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Carlos P. Modenutti"'
Autor:
Kevin P. Guay, Roberta Ibba, J.L. Kiappes, Snežana Vasiljević, Francesco Bonì, Maria De Benedictis, Ilaria Zeni, James D. Le Cornu, Mario Hensen, Anu V. Chandran, Anastassia L. Kantsadi, Alessandro T. Caputo, Juan I. Blanco Capurro, Yusupha Bayo, Johan C. Hill, Kieran Hudson, Andrea Lia, Juliane Brun, Stephen G. Withers, Marcelo Martí, Emiliano Biasini, Angelo Santino, Matteo De Rosa, Mario Milani, Carlos P. Modenutti, Daniel N. Hebert, Nicole Zitzmann, Pietro Roversi
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107919- (2023)
Summary: Misfolded glycoprotein recognition and endoplasmic reticulum (ER) retention are mediated by the ER glycoprotein folding quality control (ERQC) checkpoint enzyme, UDP-glucose glycoprotein glucosyltransferase (UGGT). UGGT modulation is a promi
Externí odkaz:
https://doaj.org/article/65e937022caf475ebc2513beca012f73
Autor:
Diego A. Caraballo, Lucila I. Buzzi, Carlos P. Modenutti, Ana Acosta-Montalvo, Olga A. Castro, María S. Rossi
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 2, Pp 755-768 (2020)
UDP- glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein folding. It is known that vertebrates and Caenorhabditis genomes harbor tw
Externí odkaz:
https://doaj.org/article/ef44b2352d1f4ae08c7f27cdad334e68
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Galectins (formerly known as “S-type lectins”) are a subfamily of soluble proteins that typically bind β-galactoside carbohydrates with high specificity. They are present in many forms of life, from nematodes and fungi to animals, where they per
Externí odkaz:
https://doaj.org/article/754c793355b4420786be1721f1e58ff5
Autor:
Lucas A. Defelipe, Juan Pablo Arcon, Carlos P. Modenutti, Marcelo A. Marti, Adrián G. Turjanski, Xavier Barril
Publikováno v:
Molecules, Vol 23, Iss 12, p 3269 (2018)
Simulations of molecular dynamics (MD) are playing an increasingly important role in structure-based drug discovery (SBDD). Here we review the use of MD for proteins in aqueous solvation, organic/aqueous mixed solvents (MDmix) and with small ligands,
Externí odkaz:
https://doaj.org/article/14e5b95b103e43228886840c33e01d16
Autor:
Gabor Tax, Kevin P Guay, Tatiana Solde, Charlie J Hitchman, Johan C Hill, Snezana Vasilievic, Andrea Lia, Carlos P Modenutti, Kornelis R Straatman, Maurizio Molinari, Angelo Santino, Daniel N Hebert, Nicole Zitzmann, Pietro Roversi, Marco Trerotola
Publikováno v:
bioRxiv
Endoplasmic reticulum (ER) retention of mis-folded glycoproteins is mediated by the ER- localised eukaryotic glycoprotein secretion checkpoint, UDP-glucose glycoprotein glucosyl-transferase (UGGT). The enzyme recognises a mis-folded glycoprotein and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90fd45800bd78bfd0c9fe66596f07ed
https://doi.org/10.1101/2023.05.30.542711
https://doi.org/10.1101/2023.05.30.542711
Autor:
Carlos P. Modenutti, Ana María Masini-Repiso, Victoria Peyret, Gabriela Coux, Liliana Muñoz, Juan Pablo Nicola, Mariano Martín, Mirta Miras, Mauco Lucas Gil Rosas, Nora B. Calcaterra, Nancy Carrasco, Romina Celeste Geysels, Graciela Testa, Gabriela Sobrero, Carlos Eduardo Bernal Barquero, Marcelo A. Martí, Malvina Signorino
Publikováno v:
J Clin Endocrinol Metab
Context Iodide transport defect (ITD) (Online Mendelian Inheritance in Man No. 274400) is an uncommon cause of dyshormonogenic congenital hypothyroidism due to loss-of-function variants in the SLC5A5 gene, which encodes the sodium/iodide symporter (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9172eddb540ebed457d1fba818d3f123
https://doi.org/10.1210/clinem/dgab283
https://doi.org/10.1210/clinem/dgab283
Autor:
Lucila I Buzzi, Carlos P. Modenutti, Diego A. Caraballo, Olga A. Castro, Ana Acosta-Montalvo, Maria Susana Rossi
Publikováno v:
G3: Genes|Genomes|Genetics
G3 (Bethesda)
G3: Genes, Genomes, Genetics, Vol 10, Iss 2, Pp 755-768 (2020)
G3 (Bethesda)
G3: Genes, Genomes, Genetics, Vol 10, Iss 2, Pp 755-768 (2020)
UDP- glucose: glycoprotein glucosyltransferase (UGGT) is a protein that operates as the gatekeeper for the endoplasmic reticulum (ER) quality control mechanism of glycoprotein folding. It is known that vertebrates and Caenorhabditis genomes harbor tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b505a597e14ecaab0098e379da58ab13
https://doi.org/10.1534/g3.119.400868
https://doi.org/10.1534/g3.119.400868
Autor:
Kevin P. Guay, Roberta Ibba, JL Kiappes, Maria De Benedictis, Ilaria Zeni, James D. Le Cornu, Mario Hensen, Anu V. Chandran, Anastassia L. Kantsadi, Alessandro T. Caputo, Juan I. Blanco Capurro, Yusupha Bayo, Johan C. Hill, Kieran Hudson, Andrea Lia, Snežana Vasiljević, Carlos P. Modenutti, Stephen G. Withers, Marcelo Martí, Emiliano Biasini, Angelo Santino, Daniel N. Hebert, Nicole Zitzmann, Pietro Roversi
Publikováno v:
SSRN Electronic Journal.
The Endoplasmic Reticulum (ER) glycoprotein folding Quality Control (ERQC) machinery aids folding of glycoproteins in the ER. Misfolded glycoprotein recognition and ER-retention is mediated by the ERQC checkpoint enzyme, the 170 kDa UDP-Glucose glyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8259f0d04ef73bea11036072882346
https://doi.org/10.2139/ssrn.4290052
https://doi.org/10.2139/ssrn.4290052
Publikováno v:
Biochimie. 197
Short linear motifs (SLiMs) are key to cell physiology mediating reversible protein-protein interactions. Precise identification of SLiMs remains a challenge, being the main drawback of most bioinformatic prediction tools, their low specificity (high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043184ed8474db182bfdac8041c5fa5b
https://pubmed.ncbi.nlm.nih.gov/35134457
https://pubmed.ncbi.nlm.nih.gov/35134457
Short linear motifs (SLiMs) are key to cell physiology mediating reversible protein-protein interactions. Precise identification of SLiMs remains a challenge, being the main drawback of most bioinformatic prediction tools their low specificity (high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cb0cc0c4fc08ff6e60310e83019c7c0
https://doi.org/10.1101/2021.08.05.455287
https://doi.org/10.1101/2021.08.05.455287