Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Carlos O Medina"'
Autor:
Siwen Hu-Lieskovan, Ngan Nguyen, Magdalena Kovacsovics-Bankowski, John Hyngstrom, Li-Chun Cheng, Jordan P McPherson, Umang Swami, Matthew H Spitzer, Johanna M Sweere, Connor P Healy, Natalia Sigal, William D Chronister, Shane A Evans, John Marsiglio, Berit Gibson, Alyssa Erickson-Wayman, Yoko S Derose, Annaleah Larson Eliason, Carlos O Medina, Ramji Srinivasan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Background Immune-related adverse events (irAEs) are major barriers of clinical management and further development of immune checkpoint inhibitors (ICIs) for cancer therapy. Therefore, biomarkers associated with the onset of severe irAEs are needed.
Externí odkaz:
https://doaj.org/article/33adf4f87d5845b590a6128eac8e0678
Autor:
Ievgen O. Koliesnik, Hedwich F. Kuipers, Carlos O. Medina, Svenja Zihsler, Dan Liu, Jonas D. Van Belleghem, Paul L. Bollyky
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The heparan sulfate mimetic PG545 (pixatimod) is under evaluation as an inhibitor of angiogenesis and metastasis including in human clinical trials. We have examined the effects of PG545 on lymphocyte phenotypes and function. We report that PG545 tre
Externí odkaz:
https://doaj.org/article/196bb47efb1d4f318ce01345ffefa341
Autor:
Hunter A. Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K. Reid, Nadine Nagy, Graham Barlow, Ben A. Falk, Carlos O. Medina, Aviv Hargil, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H. Meyer, Lucile E. Wrenshall, James D. Lord, K. Christopher Garcia, Theo D. Palmer, Lawrence Steinman, Gerald T. Nepom, Thomas N. Wight, Paul L. Bollyky, Hedwich F. Kuipers
FOXP3+regulatory T cells (Treg) depend on exogenous IL-2 for their survival and function, but circulating levels of IL-2 are low, making it unclear how Treg access this critical resourcein vivo. Here, we show that Treg use heparanase (HPSE) to access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d3a27b1b35c15b8513b6ec998e27215
https://doi.org/10.1101/2023.02.26.529772
https://doi.org/10.1101/2023.02.26.529772
Autor:
Gabrielle McDonald, Carlos O. Medina, Monika Pilichowska, John F. Kearney, Reiko Shinkura, Erik Selsing, Henry H. Wortis, Tasuku Honjo, Thereza Imanishi-Kari
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
564Igi mice have knocked-in immunoglobulin (Ig) heavy (H) and light (L) chain genes that encode an autoantibody recognizing RNA. Previously, we showed that these mice produce pathogenic IgG autoantibodies when activation-induced deaminase (AID) is ex
Externí odkaz:
https://doaj.org/article/99eb2eb4dcf34b0d9210e8223770182f
Autor:
Hunter A. Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K. Reid, Nadine Nagy, Graham Barlow, Ben A. Falk, Carlos O. Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H. Meyer, Lucile E. Wrenshall, James D. Lord, K. Christopher Garcia, Theo D. Palmer, Lawrence Steinman, Gerald T. Nepom, Thomas N. Wight, Paul L. Bollyky, Hedwich F. Kuipers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Although FOXP3+ regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are low, making it unclear how Treg access this critical resource. Here, we show that Tre
Externí odkaz:
https://doaj.org/article/378775d4b0fd41108905367cda2de0de
Autor:
Nadine Nagy, Kathryn S. Czepiel, Gernot Kaber, Darko Stefanovski, Aviv Hargil, Nina Pennetzdorfer, Robert Targ, Saranya C. Reghupaty, Thomas N. Wight, Robert B. Vernon, Rebecca L. Hull-Meichle, Payton Marshall, Carlos O. Medina, Hunter Martinez, Anissa Kalinowski, Rudolph D. Paladini, Stavros Garantziotis, Joshua W. Knowles, Paul L. Bollyky
Publikováno v:
Cells, Vol 13, Iss 20, p 1727 (2024)
Given that the extracellular matrix polymer hyaluronan (HA) has been implicated in longevity, we asked whether 4-methylumbelliferone (4-MU), an inhibitor of HA synthesis, impacts lifespan in mice. We designed a prospective study of long-term administ
Externí odkaz:
https://doaj.org/article/da7d8866843c4dd994d1c93481a81662