Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Carlos María Galmarini"'
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/a19bbf8b0a2b4a18b22c58ddd8940424
Autor:
María Virtudes Céspedes, María José Guillén, Pedro Pablo López-Casas, Francesca Sarno, Alberto Gallardo, Patricia Álamo, Carmen Cuevas, Manuel Hidalgo, Carlos María Galmarini, Paola Allavena, Pablo Avilés, Ramón Mangues
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 12, Pp 1461-1471 (2016)
We explored whether the combination of lurbinectedin (PM01183) with the antimetabolite gemcitabine could result in a synergistic antitumor effect in pancreatic ductal adenocarcinoma (PDA) mouse models. We also studied the contribution of lurbinectedi
Externí odkaz:
https://doaj.org/article/e04dcc56fc9a4aa0b3725eaea00d395c
Autor:
Jean-Marc Egly, Carlos María Galmarini, Pablo Aviles, Frédéric Coin, Emmanuel Compe, Juan Fernando Martínez-Leal, Christophe Giraudon, Carlos Mario Genes Robles, Gema Santamaría Nuñez
Figure S2. Lurbinectedin inhibits RNA synthesis and promotes Pol II degradation in different cancer cell lines. (A) Kinetics of RNA synthesis. Ewing sarcoma (A673), colon (HCT-116), cervix (HeLa) and breast (MDA-MB-231) cancer cells were treated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8da166862674f25a646031cf11cb5c
https://doi.org/10.1158/1535-7163.22503247.v1
https://doi.org/10.1158/1535-7163.22503247.v1
Autor:
Jean-Marc Egly, Carlos María Galmarini, Pablo Aviles, Frédéric Coin, Emmanuel Compe, Juan Fernando Martínez-Leal, Christophe Giraudon, Carlos Mario Genes Robles, Gema Santamaría Nuñez
Figure S3. NER machinery remains active in the presence of DRB. A dual incision assay (48) was performed by the co-incubation of NER (XPC, TFIIH, XPA, RPA, XPG and XPF) components with increasing amount of DRB (10, 20, 50 and 100µM).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cc5d82fce0c707d47533e216684b39
https://doi.org/10.1158/1535-7163.22503244.v1
https://doi.org/10.1158/1535-7163.22503244.v1
Autor:
Jean-Marc Egly, Carlos María Galmarini, Pablo Aviles, Frédéric Coin, Emmanuel Compe, Juan Fernando Martínez-Leal, Christophe Giraudon, Carlos Mario Genes Robles, Gema Santamaría Nuñez
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2b4d67b3fe474b639919f464e67012
https://doi.org/10.1158/1535-7163.22503232.v1
https://doi.org/10.1158/1535-7163.22503232.v1
Autor:
Jean-Marc Egly, Carlos María Galmarini, Pablo Aviles, Frédéric Coin, Emmanuel Compe, Juan Fernando Martínez-Leal, Christophe Giraudon, Carlos Mario Genes Robles, Gema Santamaría Nuñez
Figure S4. Proposed mechanism of action of lurbinectedin Upon administration to cancer cells, (I) lurbinectedin targets GC rich regions; (II) Pol II starts the elongation phase of transcription of activated genes after being sequentially phosphorylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd2f8e2b0670ef4b22d3a908819c18f
https://doi.org/10.1158/1535-7163.22503241.v1
https://doi.org/10.1158/1535-7163.22503241.v1
Autor:
Jean-Marc Egly, Carlos María Galmarini, Pablo Aviles, Frédéric Coin, Emmanuel Compe, Juan Fernando Martínez-Leal, Christophe Giraudon, Carlos Mario Genes Robles, Gema Santamaría Nuñez
Growth inhibitory activity of lurbinectedin on different cancer cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4d4cab59f37f97496836e65702bf37
https://doi.org/10.1158/1535-7163.22503229
https://doi.org/10.1158/1535-7163.22503229
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
Supplementary Figure S6 A) In vitro validation of NR0B1 immunofluorescent assay. Data shows images and quantitation of TC32 control cells or TC32 cells following siRNA silencing of NR0B1. B) ki67 and cleaved caspase 3 staining of Ewing sarcoma xenogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b2f345a1354049abb2c9433fb5c3aa
https://doi.org/10.1158/0008-5472.22411779
https://doi.org/10.1158/0008-5472.22411779
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
There is a great need to develop novel approaches to target oncogenic transcription factors with small molecules. Ewing sarcoma is emblematic of this need, as it depends on the continued activity of the EWS-FLI1 transcription factor to maintain the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a41e5fed271b51614f576d25c55afa1
https://doi.org/10.1158/0008-5472.c.6508293.v1
https://doi.org/10.1158/0008-5472.c.6508293.v1
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
Supplementary Table S3 Table showing list of EWS-FLI1 targets with corresponding references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8d3f08885189be9bcfca07658f53b4
https://doi.org/10.1158/0008-5472.22411770.v1
https://doi.org/10.1158/0008-5472.22411770.v1