Efficient Direct Halogenation of Unsymmetrical N-Benzyl- and N-Phenylureas with Trihaloisocyanuric Acids

Autor: Carlos M. Sanabria, Gil Mendes Viana, Marcio C. S. de Mattos, Bruno Costa, L. C. S. Aguiar

Publikováno v: Synthesis. 50:1359-1367

A simple and efficient methodology for the direct halogenation of N-phenylureas was developed using trihaloisocyanuric acids in acetonitrile at room temperature. This protocol proved to be effective for the construction of N-phenylureas with differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ed8969359378e39b8680f7a04560f1d
https://doi.org/10.1055/s-0036-1589149

Unexpected ring-closure products derived from 3-(2-allylanilino)-3-phenylacrylate esters: crystal and molecular structures of 3-acetyl-8-allyl-6-methyl-2-phenylquinolin-4-yl acetate and (2RS)-2,8-dimethyl-4-phenyl-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinolin-6-one

Autor: Justo Cobo, Carlos M. Sanabria, Alirio Palma, Adriana L. Luque, Christopher Glidewell

Publikováno v: Acta Crystallographica Section C Structural Chemistry. 72:619-626

The reactions of two 3-(2-allylanilino)-3-phenylacrylate esters with acetic anhydride and with strong acids has revealed a richly diverse reactivity providing a number of unexpected products. Thus, acetylation of ethyl 3-(2-allylanilino)-3-phenylacry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02005a7e680415155cd8df4e0e4f903a
https://doi.org/10.1107/s2053229616011062

Crystal structures of five new substituted tetrahydro-1-benzazepines with potential antiparasitic activity

Autor: Carlos M. Sanabria, Pascal Roussel, Mario A. Macías, Gilles H. Gauthier, Lina María Vélez Acosta, Leopoldo Suescun, Alirio Palma

Publikováno v: Acta Crystallographica Section C : Structural Chemistry [2014-...]
Acta Crystallographica Section C : Structural Chemistry [2014-..], 2016, 72 (5), pp.363-372. ⟨10.1107/S2053229616004885⟩
Acta Crystallographica Section C Structural Chemistry
Acta Crystallographica Section C Structural Chemistry, International Union of Crystallography, 2016, 72 (5), pp.363-372. ⟨10.1107/S2053229616004885⟩

Tetrahydro-1-benzazepines have been described as potential antiparasitic drugs for the treatment of chagas disease and leishmaniasis, two of the most important so-called `forgotten tropical diseases' affecting South and Central America, caused byTryp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6f6f0adc27f113d24f2663d8e1cde5
https://hal.science/hal-02263668

Four related benzazepine derivatives in a reaction pathway leading to a benzazepine carboxylic acid : hydrogen-bonded assembly in zero, one, two and three dimensions

Autor: Sergio A. Guerrero, Justo Cobo, Carlos M. Sanabria, Alirio Palma, Christopher Glidewell

(2R*,4S*)-Methyl 2,3,4,5-tetrahydro-1,4-epoxy-1H-benz[b]azepine-2-carboxylate, C12H13NO3, (I), and its reduction product (2R*,4S*)-methyl 4-hydroxy-2,3,4,5-tetrahydro-1H-benz[b]azepine-2-carboxylate, C12H15NO3, (II), both crystallize as single enanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe92549bb39417a95ff1ca3c2e5e3b2
https://hdl.handle.net/10023/5258

Four 1-naphthyl-substituted tetrahydro-1,4-epoxy-1-benzazepines: hydrogen-bonded structures in one, two and three dimensions

Autor: Alirio Palma, Carlos M. Sanabria, Christopher Glidewell, Sandra L. Gómez, Justo Cobo

Publikováno v: Acta crystallographica. Section C, Crystal structure communications. 66(Pt 11)

(2S*,4R*)-2-exo-(1-Naphthyl)-2,3,4,5-tetrahydro-1H-1,4-epoxy-1-benzazepine, C(20)H(17)NO, (I), crystallizes with Z' = 2 in the space group P2(1); the two independent molecules have the same absolute configuration, although this configuration is indet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3996355b88522a9fb5b0a087c6a8a968
https://pubmed.ncbi.nlm.nih.gov/21051821