Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Carlos M. Roggero"'
Autor:
Carlos M. Roggero, Victoria Esser, Lingling Duan, Allyson M. Rice, Shihong Ma, Ganesh V. Raj, Michael K. Rosen, Zhi-Ping Liu, Josep Rizo
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
The androgen receptor (AR) plays a central role in prostate cancer. Development of castration resistant prostate cancer (CRPC) requires androgen-independent activation of AR, which involves its large N-terminal domain (NTD) and entails extensive epig
Externí odkaz:
https://doaj.org/article/e7e67b262a224e239c6fb362756b46b7
Autor:
Collin Gilbreath, Shihong Ma, Lan Yu, Rajni Sonavane, Carlos M. Roggero, Anvita Devineni, Ryan Mauck, Neil B. Desai, Aditya Bagrodia, Ralf Kittler, Ganesh V. Raj, Yi Yin
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100898- (2021)
The study of DNA damage repair response (DDR) in prostate cancer is restricted by the limited number of prostate cancer cell lines and lack of surrogates for heterogeneity in clinical samples. Here, we sought to leverage our experience with patient d
Externí odkaz:
https://doaj.org/article/81556393fb8f47888a4c4ffdabdcfa43
Autor:
Xihui Liu, Suryavathi Viswanadhapalli, Shourya Kumar, Tae-Kyung Lee, Andrew Moore, Shihong Ma, Liping Chen, Michael Hsieh, Mengxing Li, Gangadhara R. Sareddy, Karla Parra, Eliot B. Blatt, Tanner C. Reese, Yuting Zhao, Annabel Chang, Hui Yan, Zhenming Xu, Uday P. Pratap, Zexuan Liu, Carlos M. Roggero, Zhenqiu Tan, Susan T. Weintraub, Yan Peng, Rajeshwar R. Tekmal, Carlos L. Arteaga, Jennifer Lippincott-Schwartz, Ratna K. Vadlamudi, Jung-Mo Ahn, Ganesh V. Raj
Publikováno v:
Nature Cancer. 3:866-884
Triple-negative breast cancer (TNBC) has a poor clinical outcome, due to a lack of actionable therapeutic targets. Herein we define lysosomal acid lipase A (LIPA) as a viable molecular target in TNBC and identify a stereospecific small molecule (ERX-
Autor:
Shihong Ma, Ganesh V. Raj, Carlos M. Roggero, Michael K. Rosen, Zhi Ping Liu, Allyson M. Rice, Victoria Esser, Lingling Duan, Josep Rizo
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0258876 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0258876 (2022)
The androgen receptor (AR) plays a central role in prostate cancer. Development of castration resistant prostate cancer (CRPC) requires androgen-independent activation of AR, which involves its large N-terminal domain (NTD) and entails extensive epig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97beabc4f18f2c8ebeba91780ffa450e
https://doi.org/10.1101/2021.10.08.463684
https://doi.org/10.1101/2021.10.08.463684
Autor:
Diego Masone, Matías A. Bustos, Diego Martin Bustos, Claudia N. Tomes, María Florencia Quevedo, Carlos M. Roggero
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:612-622
Sperm must undergo the regulated exocytosis of its dense core granule (the acrosome reaction, AR) to fertilize the egg. We have previously described that Rabs3 and 27 are organized in a RabGEF cascade within the signaling pathway elicited by exocytos
Autor:
Rajni Sonavane, Ganesh V. Raj, Aditya Bagrodia, Anvita Devineni, Ralf Kittler, Yi Yin, Lan Yu, Collin Gilbreath, Carlos M. Roggero, Shihong Ma, Neil Desai, Ryan Mauck
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100898-(2021)
Translational Oncology
Translational Oncology
The study of DNA damage repair response (DDR) in prostate cancer is restricted by the limited number of prostate cancer cell lines and lack of surrogates for heterogeneity in clinical samples. Here, we sought to leverage our experience with patient d
Autor:
Hongwei Zhao, Carlos M. Roggero, Junhang Luo, Ming Wang, Rui Tao Wang, Elizabeth Hernandez, Chun Mien Chang, Zhi Ping Liu, Jason Gao, Qing Jun Zhang, Josep Rizo, Yanping Liang, Kai Jiang Yu, Jian Lu, Guanghua Xiao, Rey Chen Pong, Yong Fang, Jun Lu, Jung-Mo Ahn, David T. Hoang, Jer Tsong Hsieh, Payal Kapur, Jiazheng Cao, Zhenhua Chen, Andrew Dang, Lingling Duan
Publikováno v:
Nucleic Acids Research
Alternative splicing is emerging as an oncogenic mechanism. In prostate cancer, generation of constitutively active forms of androgen receptor (AR) variants including AR-V7 plays an important role in progression of castration-resistant prostate cance
Autor:
Arthur P H, de Jong, Carlos M, Roggero, Meng-Ru, Ho, Man Yan, Wong, Chad A, Brautigam, Josep, Rizo, Pascal S, Kaeser
Publikováno v:
Neuron. 98(2)
Rapid and efficient synaptic vesicle fusion requires a pool of primed vesicles, the nearby tethering of Ca(2+) channels, and the presence of the phospholipid PIP(2) in the target membrane. While the presynaptic active zone mediates the first two requ
Publikováno v:
Journal of Biological Chemistry. 285:26269-26278
Regulated secretion is a fundamental process underlying the function of many cell types. In particular, acrosomal exocytosis in mammalian sperm is essential for egg fertilization. In general, exocytosis is initiated by a cytosolic calcium increase. I
Autor:
Pascal S. Kaeser, Arthur P.H. de Jong, Josep Rizo, Meng-Ru Ho, Chad A. Brautigam, Man Yan Wong, Carlos M. Roggero
Publikováno v:
Neuron. 98:335-349.e7
Rapid and efficient synaptic vesicle fusion requires a pool of primed vesicles, the nearby tethering of Ca2+ channels, and the presence of the phospholipid PIP2 in the target membrane. Although the presynaptic active zone mediates the first two requi