Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Carlos M, Guardia"'
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111268- (2024)
Summary: As advantageous as sexual reproduction is during progeny generation, it is also an expensive and treacherous reproductive strategy. The viviparous eukaryote has evolved to survive stress before, during, and after pregnancy. An important and
Externí odkaz:
https://doaj.org/article/cd418c5c682d4ae3a50309d1e507057f
Autor:
Elodie Mailler, Carlos M. Guardia, Xiaofei Bai, Michal Jarnik, Chad D. Williamson, Yan Li, Nunziata Maio, Andy Golden, Juan S. Bonifacino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
ATG9A is transmembrane autophagic machinery protein that delivers phospholipids to expanding autophagosomes. Mailler et al. show that ATG9A is required to mobilize lipids from lipid droplets for autophagosome expansion as well as mitochondrial fatty
Externí odkaz:
https://doaj.org/article/bc3b482686c54ef6a34fb727e681922d
Autor:
Amra Saric, Spencer A. Freeman, Chad D. Williamson, Michal Jarnik, Carlos M. Guardia, Michael S. Fernandopulle, David C. Gershlick, Juan S. Bonifacino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Endoplasmic reticulum (ER)-interorganelle membrane contact sites have emerged as key regulators of organelle dynamics. Here, the authors report that the ER-resident protein SNX19 mediates ER-endolysosome membrane contacts to maintain the perinuclear
Externí odkaz:
https://doaj.org/article/31d67507b07347d8ba1e4e2dbd2246c1
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/1cfc8656ceff4c329290c2ab95f1db38
Autor:
Aysegul Dilsizoglu Senol, Maura Samarani, Sylvie Syan, Carlos M Guardia, Takashi Nonaka, Nalan Liv, Patricia Latour-Lambert, Masato Hasegawa, Judith Klumperman, Juan S Bonifacino, Chiara Zurzolo
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001287 (2021)
The accumulation of α-synuclein (α-syn) aggregates in specific brain regions is a hallmark of synucleinopathies including Parkinson disease (PD). α-Syn aggregates propagate in a "prion-like" manner and can be transferred inside lysosomes to recipi
Externí odkaz:
https://doaj.org/article/8d3afd767fd24d5ca05e43b7ded91e8a
Autor:
Carlos M. Guardia, Xiao-Feng Tan, Tengfei Lian, Mitra S. Rana, Wenchang Zhou, Eric T. Christenson, Augustus J. Lowry, José D. Faraldo-Gómez, Juan S. Bonifacino, Jiansen Jiang, Anirban Banerjee
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107837- (2020)
Summary: Autophagy is a catabolic process involving capture of cytoplasmic materials into double-membraned autophagosomes that subsequently fuse with lysosomes for degradation of the materials by lysosomal hydrolases. One of the least understood comp
Externí odkaz:
https://doaj.org/article/c2bbdec4aa9f4899827cc7fabd64a7b9
Autor:
Morié Ishida, María G Otero, Christina Freeman, Pedro A Sánchez-Lara, Carlos M Guardia, Tyler Mark Pierson, Juan S Bonifacino
Publikováno v:
Human Molecular Genetics. 32:1162-1174
ADP-ribosylation factor 1 (ARF1) is a small GTPase that regulates membrane traffic at the Golgi apparatus and endosomes through recruitment of several coat proteins and lipid-modifying enzymes. Here, we report a pediatric patient with an ARF1-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c264be6b3180f891d38dc67d0f64b56d
https://doi.org/10.1093/hmg/ddac279
https://doi.org/10.1093/hmg/ddac279
Autor:
Carlos M Guardia, Raffaella De Pace, Aritra Sen, Amra Saric, Michal Jarnik, David A Kolin, Ambarish Kunwar, Juan S Bonifacino
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000279 (2019)
We report the development and characterization of a method, named reversible association with motor proteins (RAMP), for manipulation of organelle positioning within the cytoplasm. RAMP consists of coexpressing in cultured cells (i) an organellar pro
Externí odkaz:
https://doaj.org/article/5ac32a12a8e441d4a457f7d9e2882e54
Autor:
Carlos M. Guardia, Erin Kane, Alison G. Tebo, Anna A. W. M. Sanders, Devrim Kaya, Kathleen E. Grogan
Publikováno v:
Proceedings of the Royal Society B: Biological Sciences. 290
To attain a faculty position, postdoctoral fellows submit job applications that require considerable time and effort to produce. Although mentors and colleagues review these applications, postdocs rarely receive iterative feedback from reviewers with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56e20a2638e53d602d881cd58678cab3
https://doi.org/10.1098/rspb.2023.0124
https://doi.org/10.1098/rspb.2023.0124
Autor:
Chad D. Williamson, Yan Li, Juan S. Bonifacino, Carlos M. Guardia, Andy Golden, Michal Jarnik, Nunziata Maio, Elodie Mailler, Xiaofei Bai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
The multispanning membrane protein ATG9A is a scramblase that flips phospholipids between the two membrane leaflets, thus contributing to the expansion of the phagophore membrane in the early stages of autophagy. Herein, we show that depletion of ATG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1980586d818cfe1cc746966098f437a1
https://doaj.org/article/bc3b482686c54ef6a34fb727e681922d
https://doaj.org/article/bc3b482686c54ef6a34fb727e681922d