Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Carlos Luri-Rey"'
Autor:
Assunta Cirella, Elixabet Bolaños, Carlos Luri-Rey, Claudia Augusta Di Trani, Irene Olivera, Gabriel Gomis, Javier Glez-Vaz, Beatrice Pinci, Saray Garasa, Sandra Sánchez-Gregorio, Arantza Azpilikueta, Iñaki Eguren-Santamaria, Karmele Valencia, Belén Palencia, Maite Alvarez, Maria C. Ochoa, Álvaro Teijeira, Pedro Berraondo, Ignacio Melero
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 668-682 (2023)
Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with anti-PD-(L)1 monoclonal antibodies. To make the most of these approaches, we have constructed c
Externí odkaz:
https://doaj.org/article/0cbeb48e82c4432eb1d5f41226df6231
Autor:
Maite Alvarez, Carmen Molina, Saray Garasa, Maria C. Ochoa, Maria E Rodriguez-Ruiz, Gabriel Gomis, Assunta Cirella, Irene Olivera, Javier Glez-Vaz, Jose Gonzalez-Gomariz, carlos luri-Rey, arantza azpilikueta, Elixabet Bolaños, Alvaro Teijeira, Pedro Berraondo, Marisol Quintero, Ignacio Melero
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTBO-112 is a poly I:C-based viral mimetic that exerts anti-tumor efficacy when intratumorally delivered in mouse models. Intratumoral BO-112 synergizes in mice with systemic anti-PD-1 mAbs and this combination has attained efficacy in PD1-refr
Externí odkaz:
https://doaj.org/article/44e860c9bad74e59994cd04f69e8b8a5
Autor:
Ignacio Melero, Maria C Ochoa, Carmen Molina, Sandra Sanchez‐Gregorio, Saray Garasa, Carlos Luri‐Rey, Sandra Hervas‐Stubbs, Noelia Casares, Edurne Elizalde, Gabriel Gomis, Assunta Cirella, Pedro Berraondo, Alvaro Teijeira, Maite Alvarez
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract NK‐cell reactivity against cancer is conceivably suppressed in the tumor microenvironment by the interaction of the inhibitory receptor NKG2A with the non‐classical MHC‐I molecules HLA‐E in humans or Qa‐1b in mice. We found that in
Externí odkaz:
https://doaj.org/article/dad7d8e3e32044ab82bb7ccfc15b4a39
Autor:
Arantza Azpilikueta, Ignacio Melero, Sonia Guedan, Alvaro Teijeira, Lieping Chen, Maria C Ochoa, Maite Alvarez, Jose Luis Perez Gracia, Maria E Rodriguez-Ruiz, Miguel F Sanmamed, Assunta Cirella, Javier Glez-Vaz, Irene Olivera, Iñaki Eguren-Santamaria, Carlos Luri-Rey, Xinxin Nie
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background On the basis of efficacy in mouse tumor models, multiple CD137 (4-1BB) agonist agents are being preclinically and clinically developed. The costimulatory molecule CD137 is inducibly expressed as a transmembrane or as a soluble protein (sCD
Externí odkaz:
https://doaj.org/article/73397a239a8744e29c59d4accc19c284
Autor:
Assunta Cirella, Elixabet Bolaños, Claudia Augusta Di Trani, Carlos E. de Andrea, Sandra Sánchez-Gregorio, Iñaki Etxeberria, Jose Gonzalez-Gomariz, Irene Olivera, Davide Brocco, Javier Glez-Vaz, Carlos Luri-Rey, Arantza Azpilikueta, Inmaculada Rodríguez, Myriam Fernandez-Sendín, Josune Egea, Iñaki Eguren, Miguel F. Sanmamed, Belen Palencia, Alvaro Teijeira, Pedro Berraondo, Ignacio Melero
Publikováno v:
Cancer Immunology Research. 11:184-198
IL12-based local gene therapy of cancer constitutes an active area of clinical research using plasmids, mRNAs, and viral vectors. To improve antitumor effects, we have experimentally tested the combination of mRNA constructs encoding IL12 and IL18. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9a8397403353a6bbc17c21071b64cb8
https://doi.org/10.1158/2326-6066.cir-22-0373
https://doi.org/10.1158/2326-6066.cir-22-0373
Autor:
Alvaro Teijeira, Saray Garasa, Carlos Luri-Rey, Carlos de Andrea, Maria Gato, Carmen Molina, Tsuneyasu Kaisho, Assunta Cirella, Arantza Azpilikueta, Steffanie K. Wculek, Josune Egea, Irene Olivera, Inmaculada Rodriguez, Ana Rouzaut, Vladislav Verkhusha, Karmele Valencia, David Sancho, Pedro Berraondo, Ignacio Melero
Publikováno v:
Cancer Research. 82:4373-4385
The ability of conventional type-1 dendritic cells (cDC1) to cross-present tumor antigens to CD8+ T cells is critical for the induction of antitumor cytotoxic T lymphocytes. Mice that are constitutively deficient in cDC1 cells have been reported to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694ae79b1fbeda21a48d161a9c0fa80e
https://doi.org/10.1158/0008-5472.can-22-1046
https://doi.org/10.1158/0008-5472.can-22-1046
Autor:
Ignacio Melero, Pedro Berraondo, Alvaro Teijeira, Belen Palencia, Miguel F. Sanmamed, Iñaki Eguren, Josune Egea, Myriam Fernandez-Sendín, Inmaculada Rodríguez, Arantza Azpilikueta, Carlos Luri-Rey, Javier Glez-Vaz, Davide Brocco, Irene Olivera, Jose Gonzalez-Gomariz, Iñaki Etxeberria, Sandra Sánchez-Gregorio, Carlos E. de Andrea, Claudia Augusta Di Trani, Elixabet Bolaños, Assunta Cirella
Supplementary figures 1-8 and supplementary table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55de1d63f2018b5b1f25ddd31b7fe707
https://doi.org/10.1158/2326-6066.22546073
https://doi.org/10.1158/2326-6066.22546073
Autor:
Ignacio Melero, Pedro Berraondo, Alvaro Teijeira, Belen Palencia, Miguel F. Sanmamed, Iñaki Eguren, Josune Egea, Myriam Fernandez-Sendín, Inmaculada Rodríguez, Arantza Azpilikueta, Carlos Luri-Rey, Javier Glez-Vaz, Davide Brocco, Irene Olivera, Jose Gonzalez-Gomariz, Iñaki Etxeberria, Sandra Sánchez-Gregorio, Carlos E. de Andrea, Claudia Augusta Di Trani, Elixabet Bolaños, Assunta Cirella
IL12-based local gene therapy of cancer constitutes an active area of clinical research using plasmids, mRNAs, and viral vectors. To improve antitumor effects, we have experimentally tested the combination of mRNA constructs encoding IL12 and IL18. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437f9c251748ad1ccee76718bd3f677d
https://doi.org/10.1158/2326-6066.c.6551084
https://doi.org/10.1158/2326-6066.c.6551084
Autor:
Ignacio Melero, Pedro Berraondo, David Sancho, Karmele Valencia, Vladislav Verkhusha, Ana Rouzaut, Inmaculada Rodriguez, Irene Olivera, Josune Egea, Steffanie K. Wculek, Arantza Azpilikueta, Assunta Cirella, Tsuneyasu Kaisho, Carmen Molina, Maria Gato, Carlos de Andrea, Carlos Luri-Rey, Saray Garasa, Alvaro Teijeira
Supplementary figures 1-5 Supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d97b549cd2feb4a0be5fdf43202298c
https://doi.org/10.1158/0008-5472.22433328.v1
https://doi.org/10.1158/0008-5472.22433328.v1
Autor:
Ignacio Melero, Pedro Berraondo, David Sancho, Karmele Valencia, Vladislav Verkhusha, Ana Rouzaut, Inmaculada Rodriguez, Irene Olivera, Josune Egea, Steffanie K. Wculek, Arantza Azpilikueta, Assunta Cirella, Tsuneyasu Kaisho, Carmen Molina, Maria Gato, Carlos de Andrea, Carlos Luri-Rey, Saray Garasa, Alvaro Teijeira
The ability of conventional type-1 dendritic cells (cDC1) to cross-present tumor antigens to CD8+ T cells is critical for the induction of antitumor CTLs. Mice that are constitutively deficient in cDC1 cells have been reported to fail to respond to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bee62ba1fd2b4abc99634b4a75d146
https://doi.org/10.1158/0008-5472.c.6514338.v1
https://doi.org/10.1158/0008-5472.c.6514338.v1