Zobrazeno 1 - 10
of 542
pro vyhledávání: '"Carlos López-Otín"'
Autor:
Dido Carrero, Maria Pascual-Torner, Diana Álvarez-Puente, Víctor Quesada, Claudia García-Gómez, Carlos López-Otín
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The demersal fish orange roughy (Hoplostethus atlanticus) can live for up to 250 years, twenty times more than its congener silver roughy (Hoplostethus mediterraneus). Studies of Hoplostethus have focused mainly on its ecology and conservati
Externí odkaz:
https://doaj.org/article/b566199f51bc4c4a9df5343f96ee3835
Autor:
Vijay Swahari, Ayumi Nakamura, Emilie Hollville, Yu-Han Hung, Matt Kanke, C. Lisa Kurtz, Xurde M. Caravia, David Roiz-Valle, Shenghui He, Janakiraman Krishnamurthy, Sahil Kapoor, Varun Prasad, Cornelius Flowers, Matt Beck, Jeanette Baran-Gale, Norman Sharpless, Carlos López-Otín, Praveen Sethupathy, Mohanish Deshmukh
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Aging is a consequence of complex molecular changes, but whether a single microRNA (miRNA) can drive aging remains unclear. A miRNA known to be upregulated during both normal and premature aging is miR-29. We find miR-29 to also be among the
Externí odkaz:
https://doaj.org/article/d2e2c9171b5d43a3bb38718b4bf3ccda
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Aging and cancer exhibit apparent links that we will examine in this review. The null hypothesis that aging and cancer coincide because both are driven by time, irrespective of the precise causes, can be confronted with the idea that aging a
Externí odkaz:
https://doaj.org/article/76a80a11eeb04a7db0a55d5c00f815dd
Autor:
Carlos López-Otín, Guido Kroemer
Publikováno v:
Cell Stress, Vol 8, Pp 21-50 (2024)
The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7;184(1):33-63) include features of spatial compartmentalization (integrity of barriers, containment of local perturbations), maintenance of homeostasis over time (
Externí odkaz:
https://doaj.org/article/85fe0bd3bb85439eaab224c8be653abe
Autor:
Diana Campos-Iglesias, Alejandro A. Montero, Francisco Rodríguez, Carlos López-Otín, José M.P. Freije
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110135- (2024)
Summary: ADAM29 (a disintegrin and metalloprotease domain 29) is a member of the membrane-anchored ADAM family of proteins, which is highly expressed in testis and may mediate different physiological and pathological processes. Although the functions
Externí odkaz:
https://doaj.org/article/44b07d4090cd452bb51bdb7460a4f5d5
Publikováno v:
Frontiers in Aging, Vol 5 (2024)
The inexorability of the aging process has sparked the curiosity of human beings since ancient times. However, despite this interest and the extraordinary scientific advances in the field, the complexity of the process has hampered its comprehension.
Externí odkaz:
https://doaj.org/article/fa03d5557f4f46fd8f470e852aab3d77
Autor:
Yan Qiu, Benjamin Fernández-García, H. Immo Lehmann, Guoping Li, Guido Kroemer, Carlos López-Otín, Junjie Xiao
Publikováno v:
Journal of Sport and Health Science, Vol 12, Iss 1, Pp 8-35 (2023)
Exercise has long been known for its active role in improving physical fitness and sustaining health. Regular moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative and therapeutic strategy for vario
Externí odkaz:
https://doaj.org/article/13a5f00e7d88481b96a4cfd8261a7d3f
Autor:
Diana Campos-Iglesias, Julia M. Fraile, Gabriel Bretones, Alejandro A. Montero, Elena Bonzon-Kulichenko, Jesús Vázquez, Carlos López-Otín, José M. P. Freije
Publikováno v:
Cell Death and Disease, Vol 14, Iss 1, Pp 1-7 (2023)
Abstract The spindle assembly checkpoint (SAC) is an essential mechanism that ensures the accurate chromosome segregation during mitosis, thus preventing genomic instability. Deubiquitinases have emerged as key regulators of the SAC, mainly by determ
Externí odkaz:
https://doaj.org/article/494225a6be484efc921f890a1b484580
Autor:
Fernando Martin-Sanchez, Martín Lázaro, Carlos López-Otín, Antoni L Andreu, Juan Cruz Cigudosa, Milagros Garcia-Barbero
Publikováno v:
JMIR Medical Education, Vol 9, p e46366 (2023)
Externí odkaz:
https://doaj.org/article/c4f4f40564dc4bfb91e8d2d907102604
Personalized Precision Medicine for Health Care Professionals: Development of a Competency Framework
Autor:
Fernando Martin-Sanchez, Martín Lázaro, Carlos López-Otín, Antoni L Andreu, Juan Cruz Cigudosa, Milagros Garcia-Barbero
Publikováno v:
JMIR Medical Education, Vol 9, p e43656 (2023)
BackgroundPersonalized precision medicine represents a paradigm shift and a new reality for the health care system in Spain, with training being fundamental for its full implementation and application in clinical practice. In this sense, health care
Externí odkaz:
https://doaj.org/article/2227ecd6c35747c68d9f8d345f96a752