Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Carlos Kikuti"'
Autor:
Daniel Auguin, Julien Robert-Paganin, Stéphane Réty, Carlos Kikuti, Amandine David, Gabriele Theumer, Arndt W. Schmidt, Hans-Joachim Knölker, Anne Houdusse
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Inherited cardiomyopathies are common cardiac diseases worldwide, leading in the late stage to heart failure and death. The most promising treatments against these diseases are small molecules directly modulating the force produced by β-car
Externí odkaz:
https://doaj.org/article/363d3a02b7d54aa8bbcb3c56b4a01f3f
Autor:
Louise Canon, Carlos Kikuti, Vicente J. Planelles-Herrero, Tianming Lin, Franck Mayeux, Helena Sirkia, Young il Lee, Leila Heidsieck, Léonid Velikovsky, Amandine David, Xiaoyan Liu, Dihia Moussaoui, Emma Forest, Peter Höök, Karl J. Petersen, Tomos E. Morgan, Aurélie Di Cicco, Julia Sirés-Campos, Emmanuel Derivery, Daniel Lévy, Cédric Delevoye, H. Lee Sweeney, Anne Houdusse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Myosin VI (Myo6) is the only minus-end directed nanomotor on actin, allowing it to uniquely contribute to numerous cellular functions. As for other nanomotors, the proper functioning of Myo6 relies on precise spatiotemporal control of motor
Externí odkaz:
https://doaj.org/article/9c1a197ee24d4bfc8261601e8244d9ad
Autor:
Alessandro Grinzato, Daniel Auguin, Carlos Kikuti, Neha Nandwani, Dihia Moussaoui, Divya Pathak, Eaazhisai Kandiah, Kathleen M. Ruppel, James A. Spudich, Anne Houdusse, Julien Robert-Paganin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract To save energy and precisely regulate cardiac contractility, cardiac muscle myosin heads are sequestered in an ‘off’ state that can be converted to an ‘on’ state when exertion is increased. The ‘off’ state is equated with a folde
Externí odkaz:
https://doaj.org/article/0c05293899494749a2e39fe8e07c3200
Autor:
Fanomezana Moutse Ranaivoson, Vincent Crozet, Matthieu P. M. H. Benoit, Amna Abdalla Mohammed Khalid, Carlos Kikuti, Helena Sirkia, Ahmed El Marjou, Stéphanie Miserey-Lenkei, Ana B. Asenjo, Hernando Sosa, Christoph F. Schmidt, Steven S. Rosenfeld, Anne Houdusse
Publikováno v:
Open Biology, Vol 13, Iss 9 (2023)
KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling between the nucleotide- and microtubule-binding sites of this kinesin
Externí odkaz:
https://doaj.org/article/d507f9c467904d2fad8c1e25083b89b1
Autor:
Lara Katharina Krüger, Matthieu Gélin, Liang Ji, Carlos Kikuti, Anne Houdusse, Manuel Théry, Laurent Blanchoin, Phong T Tran
Publikováno v:
eLife, Vol 10 (2021)
Mitotic spindle function depends on the precise regulation of microtubule dynamics and microtubule sliding. Throughout mitosis, both processes have to be orchestrated to establish and maintain spindle stability. We show that during anaphase B spindle
Externí odkaz:
https://doaj.org/article/5e8cfa0e216d4ab2b63cacf0a66832a1
Autor:
Constanze Erdmann, Roua Hassoun, Sebastian Schmitt, Carlos Kikuti, Anne Houdusse, Antonina J. Mazur, Andreas Mügge, Nazha Hamdani, Matthias Geyer, Kornelia Jaquet, Hans Georg Mannherz
Publikováno v:
Antioxidants, Vol 10, Iss 7, p 1082 (2021)
The human mutant cardiac α-actins p.A295S or p.R312H and p.E361G, correlated with hypertrophic or dilated cardiomyopathy, respectively, were expressed by the baculovirus/Sf21 insect cell system and purified to homogeneity. The purified cardiac actin
Externí odkaz:
https://doaj.org/article/eb753d4bf5df46adb87a057ae7098888
Autor:
I-Mei Yu, Vicente J. Planelles-Herrero, Yannick Sourigues, Dihia Moussaoui, Helena Sirkia, Carlos Kikuti, David Stroebel, Margaret A. Titus, Anne Houdusse
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Cadherin is essential for mechanotransduction and myosin-adaptor-harmonin complexes anchor it to actin. Here the authors present the structures of myosin 7 MF2 domains bound to the harmonin PDZ3c domain and give insights into myosin-adaptor-harmonin
Externí odkaz:
https://doaj.org/article/aa24a24d03664dbc891f02ce9745c6cd
Autor:
Stéphane Frémont, Hussein Hammich, Jian Bai, Hugo Wioland, Kerstin Klinkert, Murielle Rocancourt, Carlos Kikuti, David Stroebel, Guillaume Romet-Lemonne, Olena Pylypenko, Anne Houdusse, Arnaud Echard
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Cytokinetic abscission relies on the local constriction after cytoskeleton disassembly, but it is not known how the actin filaments are disassembled. Here, the authors show that the redox enzyme MICAL1 is recruited by Rab35 and induces oxidation-medi
Externí odkaz:
https://doaj.org/article/ef2347de83094d2db6126f7699dfdbc7
Autor:
Monalisa Mukherjea, M. Yusuf Ali, Carlos Kikuti, Daniel Safer, Zhaohui Yang, Helena Sirkia, Virginie Ropars, Anne Houdusse, David M. Warshaw, H. Lee Sweeney
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1522-1532 (2014)
It is unclear whether the reverse-direction myosin (myosin VI) functions as a monomer or dimer in cells and how it generates large movements on actin. We deleted a stable, single-α-helix (SAH) domain that has been proposed to function as part of a l
Externí odkaz:
https://doaj.org/article/b43640e9c1204849bad421793731c53f
Autor:
Fanomezana Moutse Ranaivoson, Vincent Crozet, Matthieu P.M.H. Benoît, Amna Abdalla Mohammed Khalid, Carlos Kikuti, Helena Sirkia, Ahmed El Marjou, Ana B. Asenjo, Hernando Sosa, Christoph F. Schmidt, Steven S. Rosenfeld, Anne Houdusse
KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling between the nucleotide- and microtubule-binding sites of this kinesin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0572c4ace8cd33584c3000d2d01bd79e
https://doi.org/10.1101/2022.11.10.515925
https://doi.org/10.1101/2022.11.10.515925