Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Carlos J. V. Simões"'
Autor:
Maryam Abbasi, Beatriz P. Santos, Tiago C. Pereira, Raul Sofia, Nelson R. C. Monteiro, Carlos J. V. Simões, Rui Brito, Bernardete Ribeiro, José L. Oliveira, Joel P. Arrais
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Drug design is an important area of study for pharmaceutical businesses. However, low efficacy, off-target delivery, time consumption, and high cost are challenges and can create barriers that impact this process. Deep Learning models are em
Externí odkaz:
https://doaj.org/article/7198e0181ce94996b3f69a3a3350a466
Autor:
Nelson R. C. Monteiro, Carlos J. V. Simões, Henrique V. Ávila, Maryam Abbasi, José L. Oliveira, Joel P. Arrais
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract Background Several computational advances have been achieved in the drug discovery field, promoting the identification of novel drug–target interactions and new leads. However, most of these methodologies have been overlooking the importan
Externí odkaz:
https://doaj.org/article/ce862bbbb14f4e208b0489dee1f9f22c
Autor:
Maryam Abbasi, Beatriz P. Santos, Tiago C. Pereira, Raul Sofa, Nelson R. C. Monteiro, Carlos J. V. Simões, Rui M. M. Brito, Bernardete Ribeiro, José L. Oliveira, Joel P. Arrais
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/ccc789eb92534ee6ab688a2fcb874b75
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
In silico methodologies have opened new avenues of research to understanding and predicting drug resistance, a pressing health issue that keeps rising at alarming pace. Sequence-based interpretation systems are routinely applied in clinical context i
Externí odkaz:
https://doaj.org/article/aad212a950484fa5b9b3b14567a1fe1e
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2977
Volume 24
Issue 3
Pages: 2977
Influenza viruses are responsible for significant morbidity and mortality worldwide in winter seasonal outbreaks and in flu pandemics. Influenza viruses have a high rate of evolution, requiring annual vaccine updates and severely diminishing the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8e0ea56984ce84a7f83d41e5ae7b9f
https://doi.org/10.3390/ijms24032977
https://doi.org/10.3390/ijms24032977
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 5; Pages: 2599
Interleukin-1 receptor type 1 (IL-1R1) is a key player in inflammation and immune responses. This receptor regulates IL-1 activity in two forms: as a membrane-bound form and as a soluble ectodomain. The details and differences between the conformatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757badb646fc94aa11f2b7115980bc67
https://pubmed.ncbi.nlm.nih.gov/35269739
https://pubmed.ncbi.nlm.nih.gov/35269739
Autor:
Teresa Nascimento, Denise Francisco, Helena Barroso, Américo J. S. Alves, Carlos J. V. Simões, João Rocha, Diana Fontinha, Miguel Prudêncio, Nuno G. Alves, Marta Machado, Bruno Sepodes, Helder Mota-Filipe, Bruna S. Santos, António P Alves de Matos, Rui Pinto, Nuno Taveira, Teresa M. V. D. Pinho e Melo, Maria Eduardo Figueira, Inês Bártolo
Publikováno v:
ACS infectious diseases. 7(2)
The high burden of malaria and HIV/AIDS prevents economic and social progress in developing countries. A continuing need exists for development of novel drugs and treatment regimens for both diseases in order to address the tolerability and long-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170b82ce1253edf46d3e2681f6bce479
https://pubmed.ncbi.nlm.nih.gov/33395253
https://pubmed.ncbi.nlm.nih.gov/33395253
Autor:
Denise Francisco, Inês Bártolo, Maria I. L. Soares, Nuno G. Alves, Susana Lopes, Teresa M. V. D. Pinho e Melo, Américo J. S. Alves, Nuno Taveira, Diana Fontinha, Miguel Prudêncio, Carlos J. V. Simões
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
© 2021 Elsevier Masson SAS. All rights reserved.
The synthesis and antimicrobial activity of new spiro-β-lactams is reported. The design of the new molecules was based on the structural modulation of two previously identified lead spiro-penici
The synthesis and antimicrobial activity of new spiro-β-lactams is reported. The design of the new molecules was based on the structural modulation of two previously identified lead spiro-penici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e9998b1b0974b5f04598640674932e
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1731, p 1731 (2022)
The interleukin-1 receptor type 1 (IL-1R1) holds pivotal roles in the immune system, as it is positioned at the “epicenter” of the inflammatory signaling networks. Increased levels of the cytokine IL-1 are a recognized feature of the immune respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6876449458dbc64d3686d1c80fd6517
https://doi.org/10.3390/ijms23031731
https://doi.org/10.3390/ijms23031731
Autor:
Zaida L. Almeida, João Melo Beirão, Filipa Bezerra, Rui M. M. Brito, Maria João Saraiva, Carlos J. V. Simões, Teresa M. V. D. Pinho e Melo, Maria Rosário Almeida, Ana L. Cardoso
Publikováno v:
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 26(sup1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b65f328b472adcd6b17f53dbba5debe
https://pubmed.ncbi.nlm.nih.gov/31343302
https://pubmed.ncbi.nlm.nih.gov/31343302