Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Carlos J. Rodriguez-Ortiz"'
Autor:
David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C. Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I. Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A. Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J. Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P. Matheos, Xinyi Ma, Celia Da Cunha, Ken C. Walls, Rahasson R. Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J. Tenner, Grant R. MacGregor, Marcelo Wood, Kim N. Green, Frank M. LaFerla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelli
Externí odkaz:
https://doaj.org/article/1e311a8bbdd34a96bb987b252f4dfaaf
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Externí odkaz:
https://doaj.org/article/25efe09cb2254ee3a9fc053075e54365
Autor:
David Baglietto-Vargas, Masashi Kitazawa, Elaine J. Le, Tatiana Estrada-Hernandez, Carlos J. Rodriguez-Ortiz, Rodrigo Medeiros, Kim N. Green, Frank M. LaFerla
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 407-415 (2014)
Recent studies on tauopathy animal models suggest that the concomitant expression of the endogenous murine tau delays the pathological accumulation of human tau, and interferes with the disease progression. To elucidate the role of endogenous murine
Externí odkaz:
https://doaj.org/article/2e1978d880a945a6ae992d34a6d1b1c9
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Carlos J. Rodriguez‐Ortiz, Max A. Thorwald, Ruben Rodriguez, Marina Mejias‐Ortega, Zanett Kieu, Neilabjo Maitra, Charlesice Hawkins, Joanna Valenzuela, Marcus Peng, Akira Nishiyama, Rudy M. Ortiz, Masashi Kitazawa
Publikováno v:
Clinical and experimental pharmacologyphysiologyREFERENCES.
Metabolic syndrome (MetS) is a rapidly increasing health concern during midlife and is an emerging risk factor for the development of neurodegenerative diseases, such as Alzheimer's disease (AD). While angiotensin receptor blockers (ARB) are widely u
Autor:
Carlos J. Rodriguez-Ortiz, Victoria Gallup, Siok Lam Lim, Emmanuel Villanueva, Sagar Ghiaar, Zanett Kieu, Diana Nguyen Tran, Masashi Kitazawa, David H. Cribbs, Christine Chen, Joannee Zumkehr
Publikováno v:
Molecular neurobiology, vol 57, iss 5
Mol Neurobiol
Mol Neurobiol
Microglial dysregulation, pertaining to impairment in phagocytosis, clearance and containment of amyloid-β (Aβ), and activation of neuroinflammation, has been posited to contribute to the pathogenesis of Alzheimer's disease (AD). Detailed cellular
Autor:
Antonia Gutierrez, Rahasson R. Ager, Angela Gomez-Arboledas, Amanda McQuade, Carlos J. Rodriguez-Ortiz, Jose Carlos Davila, Jimmy Phan, Mathew Blurton-Jones, Stefania Forner, Celia da Cunha, Masashi Kitazawa, Laura Trujillo-Estrada, Melanie Tram, David Baglietto-Vargas, Alessandra C. Martini, Jordan-Vu Ha, Dominic I. Javonillo, Emma Danhash, Rodrigo Medeiros, Frank M. LaFerla
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance As we age, the innate immune system becomes dysregulated and is characterized by persistent inflammatory responses, and the chronic inflammation mediated by inflammatory receptors represents a key mechanism by which amyloid-beta (Aβ) dr
Autor:
Jie Wu, Heng-Wei Hsu, Masashi Kitazawa, Janielle Vidal, Pinar Ayata, Jason Kilian, Siok Lam Lim, Joannee Zumkehr, Carlos J. Rodriguez-Ortiz
Publikováno v:
J Trace Elem Med Biol
Background Copper (Cu) is an essential metal mediating a variety of vital biological reactions with its redox property. Its dyshomeostasis has been associated with accelerated cognitive decline and neurodegenerative disorders, such as Alzheimer’s d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570da0ea0939a419bba6b75f8a5f2daa
https://escholarship.org/uc/item/63b2t126
https://escholarship.org/uc/item/63b2t126
Publikováno v:
Neuroscience
Effective clearance of neurotoxic amyloid-beta (Aβ) from the brain is a critical process to prevent Alzheimer’s disease (AD). One major clearance mechanism is Aβ transcytosis mediated by low-density lipoprotein receptor-related protein 1 (LRP1) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e67fb7512a293c6d117233671d721a1
https://europepmc.org/articles/PMC7796931/
https://europepmc.org/articles/PMC7796931/
Autor:
Masashi Kitazawa, Frank M. LaFerla, Carlos J. Rodriguez-Ortiz, Alessandra C. Martini, David Baglietto-Vargas, Laura Trujillo-Estrada, Stefania Forner, Gilberto Aleph Prieto, Carl W. Cotman
Publikováno v:
Aging Cell
Aging cell, vol 19, iss 3
Aging cell, vol 19, iss 3
MicroRNAs play a pivotal role in rapid, dynamic, and spatiotemporal modulation of synaptic functions. Among them, recent emerging evidence highlights that microRNA‐181a (miR‐181a) is particularly abundant in hippocampal neurons and controls the e