Výsledky vyhledávání - "Carlos J. E. Niemegeers"

Survey on the pharmacodynamics of the new antipsychotic risperidone

Autor: Anton Megens, J. E. Leysen, Theo F. Meert, Carlos J. E. Niemegeers, Christine Dugovic, Alain Schotte, Frans Awouters

Publikováno v: Psychopharmacology. 114:9-23

This review reports on the pharmacodynamics of the new antipsychotic risperidone. The primary action of risperidone is serotonin 5-HT2 receptor blockade as shown by displacement of radioligand binding (Ki: 0.16 nM), activity on isolated tissues (EC50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949e82103102d1878b482b5339e85be3
https://doi.org/10.1007/bf02245439

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Loperamide

Autor: Frans Awouters, J. A. J. Schuurkes, Paul A. J. Janssen, Anton Megens, M. Verlinden, Carlos J. E. Niemegeers

Publikováno v: Digestive Diseases and Sciences. 38:977-995

In castor oil challenged rats, low doses of loperamide inhibit diarrhea and normalize intestinal propulsion. Unlike other opioids, loperamide is devoid of central opiate-like effects, including blockade of intestinal propulsion, up to the highest sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597d98529899a261ccc6c242aaad7371
https://doi.org/10.1007/bf01295711

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Antipsychotic profile and side-effect liability of haloperidol, risperidone, and ocaperidone as predicted from their differential interaction with amphetamine in rats

Autor: Carlos J. E. Niemegeers, Anton Megens, Frans Awouters

Publikováno v: Drug Development Research. 26:129-145

Motor activity effects of haloperidol, risperidone, and ocaperidone were studied in rats challenged with amphetamine. At a low dose of amphetamine, the compounds were about equipotent in reducing amphetamine-induced hyperactivity to normal values (lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fea8b048a1b3a5d31d00387d821e089a
https://doi.org/10.1002/ddr.430260203

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Comparison of the in vivo pharmacological profiles of sabeluzole and its enantiomers

Autor: Anton Megens, Raymond Antoine Stokbroekx, Carlos J. E. Niemegeers, Leen Werbrouck

Publikováno v: Drug Development Research. 24:41-51

Sabeluzole, a compound with pronounced cognitive enhancing, antihypoxic, and anticonvulsant properties, is the racemic mixture of the enantiomers R 84 439 (R-configuration) and R 84 440 (S-configuration). Sabeluzole and its separate enantiomers were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a03fd7ca99e51e852f6824a62c2da60
https://doi.org/10.1002/ddr.430240104

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Levocabastine: pharmacological profile of a highly effective inhibitor of allergic reactions

Autor: Anton Megens, Frans Awouters, Carlos J. E. Niemegeers, T. Jansen, P. A. J. Janssen

Publikováno v: Agents and actions. 35(1-2)

Levocabastine, selected from a series of cyclohexylpiperidine derivatives protects rats from compound 48/80-induced anaphylactic shock for at least 16 h at the oral dose of 0.0015 mg/kg. At the same dose histamine skin reactions and at slightly highe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822aebae205a4b5ef9eb174c94c8be22
https://pubmed.ncbi.nlm.nih.gov/1354927

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Normalization of small intestinal propulsion with loperamide-like antidiarrheals in rats

Autor: Luc L. J. Canters, Frans Awouters, Carlos J. E. Niemegeers, Anton Megens

Publikováno v: European journal of pharmacology. 178(3)

Gastrointestinal propulsion and the presence of diarrhea were assessed in rats pretreated with various opioids and challenged orally with either castor or paraffin oil, which both contained phenol red as a marker of gastrointestinal propulsion. In so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa90a8d39a2361f7c357ede9dafd6e1
https://pubmed.ncbi.nlm.nih.gov/2340864

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Serotonin Involvement in the Action of Antipsychotic Drugs

Autor: Frans Awouters, P. A. J. Janssen, Carlos J. E. Niemegeers

Publikováno v: Serotonin ISBN: 9789401073530

The study of the interaction of antipsychotic drugs with central neurotransmission has implicated serotonin at least as early as dopamine. The interest in serotonin antagonism was not sustained because central dopamine D2 antagonism was found to be t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d676edcfba9859d9ba95b5fdd975cd7
https://doi.org/10.1007/978-94-009-1912-9_70

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