Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Carlos J. Bosques"'
Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation
Autor:
Christopher Beneduce, Stephanie Nguyen, Nathaniel Washburn, John Schaeck, Robin Meccariello, Kimberly Holte, Daniel Ortiz, Anthony M. Manning, Carlos J. Bosques, Elma Kurtagic
Publikováno v:
Cells, Vol 12, Iss 17, p 2130 (2023)
Immunoglobulin (IgG) Fc glycosylation has been shown to be important for the biological activity of antibodies. Fc sialylation is important for the anti-inflammatory activity of IgGs. However, evaluating the structure–activity relationship (SAR) of
Externí odkaz:
https://doaj.org/article/596cb9d1b1e841fbb5b6fd29af19e280
Autor:
Elizabeth M. Bailey, Amit Choudhury, Harika Vuppula, Daniel F. Ortiz, John Schaeck, Anthony M. Manning, Carlos J. Bosques, Adam D. Hoppe
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
The inhibition of Fcγ receptors (FcγR) is an attractive strategy for treating diseases driven by IgG immune complexes (IC). Previously, we demonstrated that an engineered tri-valent arrangement of IgG1 Fc domains (SIF1) potently inhibited FcγR act
Externí odkaz:
https://doaj.org/article/8a739341b0694c8a9728764280839ac7
Autor:
Nathaniel Washburn, Robin Meccariello, Shaohui Hu, Maurice Hains, Naveen Bhatnagar, Hetal Sarvaiya, Bulbul Kapoor, John Schaeck, Ignacio Pino, Anthony Manning, Jonathan C Lansing, Carlos J Bosques
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181251 (2017)
Intravenous immunoglobulin (IVIg) is a complex mixture drug comprising diverse immunoglobulins and non-IgG proteins purified from the plasma of thousands of healthy donors. Approved IVIg products on the market differ regarding source of plasma, isola
Externí odkaz:
https://doaj.org/article/810e740f2ece44d3987135491a036d73
Autor:
Robert Prenovitz, Nathaniel Washburn, Jay Duffner, Carlos J. Bosques, Anthony M. Manning, Ganesh Kaundinya, Robin Meccariello, Jonathan C. Lansing, Thomas Prod’homme, Ishan Capila, Karunya Srinivasan, Kristen Getchell, Kimberly Holte
Publikováno v:
Molecular & Cellular Proteomics : MCP
Characterization of endogenous FcγRIII glycosylation from healthy donors with different FcγRIIIb genotypes reveals site specific, and allele specific differences in glycosylation as well as noncananonical sequence specific differences in glycosylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefb5da0df94b01a05bcaf91520eaf3c
https://doi.org/10.1074/mcp.ra118.001142
https://doi.org/10.1074/mcp.ra118.001142
Publikováno v:
International journal of cosmetic scienceReferences. 43(1)
Because of the strong consumer driver towards more natural or higher sustainability cosmetic products, silk fibroin was evaluated to help develop a formulation with natural and effective ingredients for personal care. In order to exploit the physical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43dfa75c9cca356db757edcbe2a3ed7d
https://pubmed.ncbi.nlm.nih.gov/33259636
https://pubmed.ncbi.nlm.nih.gov/33259636
Autor:
Pauline M. Rudd, Anthony M. Manning, Lori B. Daniels, Ganesh Kaundinya, Simone Albrecht, John B. Gordon, Laura Koppes, Jane C. Burns, Jun Oyamada, Carlos J. Bosques, Radka Saldova, Shinsuke Hoshino, Adriana H. Tremoulet, Hetal Sarvaiya, Victor Farutin, Andrew M. Kahn, Ishan Capila, Jay Duffner, Nur Sibel Gunay, Jamey Guess, Henning Stöckmann, Chisato Shimizu, Leona E. Ling, Dorota A. Bulik, Bulbul Kapoor, Ciara A. McManus, Bryan Gutierrez, Miroslaw Lech
Publikováno v:
Circulation: Genomic and Precision Medicine. 12
Background: The sequelae of Kawasaki disease (KD) vary widely with the greatest risk for future cardiovascular events among those who develop giant coronary artery aneurysms (CAA). We sought to define the molecular signature associated with different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caf60c78db9a49756983e235c1e4006
https://doi.org/10.1161/circgen.118.002433
https://doi.org/10.1161/circgen.118.002433
Publikováno v:
Current topics in microbiology and immunology. 423
Over 80 different autoimmune disorders have been identified. A common denominator across most of these disorders is the presence of pathogenic autoantibodies. The pathogenic and inflammatory nature of antibodies is well accepted, and over the last th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc7634710cc8695a18b10b633f7fffbd
https://pubmed.ncbi.nlm.nih.gov/30790077
https://pubmed.ncbi.nlm.nih.gov/30790077
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783030310523
Over 80 different autoimmune disorders have been identified. A common denominator across most of these disorders is the presence of pathogenic autoantibodies. The pathogenic and inflammatory nature of antibodies is well accepted, and over the last th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6047d47269d3d9da4735c403bce6a1b1
https://doi.org/10.1007/82_2019_148
https://doi.org/10.1007/82_2019_148
Autor:
Yannic C. Bartsch, Vinidhra Mani, Kai-Ting C. Shade, Thorsten R. Mempel, Michelle E. Conroy, Edda Fiebiger, Barbara Platzer, Carlos J. Bosques, Jose D. Pagan, Nathaniel Washburn, Robert M. Anthony
Publikováno v:
The Journal of Experimental Medicine
Shade et al. demonstrate the requirement for IgE glycosylation in allergic reactions.
Immunoglobulin ε (IgE) antibodies are the primary mediators of allergic diseases, which affect more than 1 in 10 individuals worldwide. IgE specific for innoc
Immunoglobulin ε (IgE) antibodies are the primary mediators of allergic diseases, which affect more than 1 in 10 individuals worldwide. IgE specific for innoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a22aafe2ebabd0804c0b953d5e39ca
https://doi.org/10.1084/jem.20142182
https://doi.org/10.1084/jem.20142182
Autor:
Laura Rutitzky, Daniel F. Ortiz, Jonathan C. Lansing, Julia Brown, Joseph Paquette, Kevin Garofalo, Josephine D'Alessandro, Naveen Bhatnagar, Maurice Hains, Abhinav Gupta, Stan Lee, Radouane Zouaoui, Jason Wang, John Schaeck, Salvatore Marchese, Robin Meccariello, Nathaniel Washburn, Kimberly Holte, Carlos J. Bosques, Anthony M. Manning
Publikováno v:
Cancer Research. 79:3244-3244
Numerous therapeutic monoclonal antibodies (mAbs) rely on antibody-dependent cell cytotoxicity (ADCC), antibody-dependent cell phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC) Fc effector functions to deplete target cells and achieve c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf0c014a499f281c36f74e93ab3210ff
https://doi.org/10.1158/1538-7445.am2019-3244
https://doi.org/10.1158/1538-7445.am2019-3244