Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Carlos J Rosado"'
Autor:
Ruth M Kennan, Wilson Wong, Om P Dhungyel, Xiaoyan Han, David Wong, Dane Parker, Carlos J Rosado, Ruby H P Law, Sheena McGowan, Shane B Reeve, Vita Levina, Glenn A Powers, Robert N Pike, Stephen P Bottomley, A Ian Smith, Ian Marsh, Richard J Whittington, James C Whisstock, Corrine J Porter, Julian I Rood
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001210 (2010)
Many bacterial pathogens produce extracellular proteases that degrade the extracellular matrix of the host and therefore are involved in disease pathogenesis. Dichelobacter nodosus is the causative agent of ovine footrot, a highly contagious disease
Externí odkaz:
https://doaj.org/article/468ef5017baf44698c215e055cd8aa6f
Autor:
Chris Tikellis, Gardner N. Robinson, Carlos J. Rosado, Duygu Batu, Maria A. Zuniga-Gutierrez, Raelene J. Pickering, Merlin C. Thomas
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 987 (2022)
Circulating levels of soluble ACE2 are increased by diabetes. Although this increase is associated with the presence and severity of cardiovascular disease, the specific role of soluble ACE2 in atherogenesis is unclear. Previous studies suggested tha
Externí odkaz:
https://doaj.org/article/8055f66bf6ed4d62bf58da6cb400a7df
Publikováno v:
Journal of Colloid and Interface Science. 591:96-105
Proteins generally tend to aggregate with less desirable properties in numerous solvents, which is one of the major challenges in the development of solvents for functional proteins. This work aims to utilize fluorescence spectroscopy and small angle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d762d42a7aadd6a6a964c1d2d6fbeb75
https://doi.org/10.1016/j.jcis.2021.02.002
https://doi.org/10.1016/j.jcis.2021.02.002
Autor:
Yasith Mathangasinghe, Niels Alberts, Carlos J. Rosado, Dezerae Cox, Natalie L. Payne, Angelique R. Ormsby, Keziban Merve Alp, Roman Sakson, Sanjeev Uthishtran, Thomas Ruppert, Senthil Arumugam, Danny M. Hatters, Harm H. Kampinga, Nadinath B. Nillegoda
The collapse of protein homeostasis manifests itself in a toxic protein aggregation cascade, which is associated with degenerative diseases and aging. To solubilize aggregates, dedicated protein disaggregases exist in unicellular organisms, but these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a69941d43c1683cb66bf8250eaca6b39
https://doi.org/10.1101/2022.06.25.497591
https://doi.org/10.1101/2022.06.25.497591
Autor:
Thomas W.H. Kay, Nisha Venkatesh, Helen E. Thomas, Carlos J. Rosado, Natalie Astbury, Balasubramanian Krishnamurthy, Evan Pappas, David N O'Neal, Merlin C. Thomas, Richard J MacIsaac
Publikováno v:
Diabetic Medicine
Aims Aim of this study is to report severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, responsible for coronavirus disease 2019 (COVID‐19), as a possible cause for type 1 diabetes by providing an illustrative clinical case
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1386bea208c6cf56b146bbd9e41399e
https://pubmed.ncbi.nlm.nih.gov/34043837
https://pubmed.ncbi.nlm.nih.gov/34043837
Publikováno v:
Journal of nephrology. 33(5)
Increased glycolytic flux into the diabetic kidney, combined with glycolytic inefficiencies introduced by oxidative stress, acts to increase the generation of triose-phosphate intermediates, which spontaneously degrade to form methylglyoxal. At the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f332caec32454936f8204e9a23eabc
https://pubmed.ncbi.nlm.nih.gov/32170575
https://pubmed.ncbi.nlm.nih.gov/32170575
Autor:
Christos Tikellis, Carlos J. Rosado, Karin Jandeleit-Dahm, Elizabeth K. M. Johnstone, Ruth M. Seeber, Mark E. Cooper, Kevin D. G. Pfleger, Raelene Pickering, Monique Smith, Jonathan Golledge, Merlin C. Thomas, Rekhati S. Abhayawardana, Yutang Wang, Alexandra Dimitropoulos, Olivier Huet, Despina Tsorotes
Activation of the type 1 angiotensin II receptor (AT(1)) triggers proinflammatory signaling through pathways independent of classical Gq signaling that regulate vascular homeostasis. Here, we report that the AT(1) receptor preformed a heteromeric com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f0ba1f9f1baf6d6c1fd7d64ac2904c
https://europepmc.org/articles/PMC6307942/
https://europepmc.org/articles/PMC6307942/
Autor:
Arpeeta Sharma, Geetha Mathew, Judy B. de Haan, Raelene Pickering, Magith Thambi, Mazhuvancherry Kesavan Unnikrishnan, Carlos J. Rosado, Jeremie Lemarie, Jayesh Mudgal, Sarine Sebastian, Karin Jandeleit-Dahm
Publikováno v:
Free radical research. 52(10)
Inflammation is a protective immune response against invading pathogens, however, dysregulated inflammation is detrimental. As the complex inflammatory response involves multiple mediators, including the involvement of reactive oxygen species, concom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bea2fe5b0f0d67e1cdbc84c97187d2
https://pubmed.ncbi.nlm.nih.gov/30422019
https://pubmed.ncbi.nlm.nih.gov/30422019
Autor:
Arpeeta Sharma, Shareefa Buksh, Judy B. de Haan, Raelene Pickering, Mitchel Tate, Carlos J. Rosado
Publikováno v:
Clinical & Translational Immunology
Diabetes is considered a major burden on the healthcare system of Western and non‐Western societies with the disease reaching epidemic proportions globally. Diabetic patients are highly susceptible to developing micro‐ and macrovascular complicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8300ccafd100d49b1adf55bf797c6009
https://pubmed.ncbi.nlm.nih.gov/29713471
https://pubmed.ncbi.nlm.nih.gov/29713471
Autor:
Wilson Wong, James C. Whisstock, Ruth M. Kennan, Carlos J. Rosado, Corrine Joy Porter, Julian I. Rood
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 66:289-293
Dichelobacter nodosus is the principal causative agent of ovine footrot, a disease of significant economic importance to the sheep industry. D. nodosus secretes a number of subtilisin-like serine proteases which mediate tissue damage and presumably c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a28e3b746f51f28533d2230ea98072e
https://doi.org/10.1107/s1744309110000333
https://doi.org/10.1107/s1744309110000333