Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Carlos I. Ayala"'
Autor:
Dongsung Kim, Lorenz Herdeis, Dorothea Rudolph, Yulei Zhao, Jark Böttcher, Alberto Vides, Carlos I. Ayala-Santos, Yasin Pourfarjam, Antonio Cuevas-Navarro, Jenny Y. Xue, Andreas Mantoulidis, Joachim Bröker, Tobias Wunberg, Otmar Schaaf, Johannes Popow, Bernhard Wolkerstorfer, Katrin Gabriele Kropatsch, Rui Qu, Elisa de Stanchina, Ben Sang, Chuanchuan Li, Darryl B. McConnell, Norbert Kraut, Piro Lito
Publikováno v:
Nature.
KRAS is one of the most commonly mutated proteins in cancer, and efforts to directly inhibit its function have been continuing for decades. The most successful of these has been the development of covalent allele-specific inhibitors that trap KRAS G1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409e1bd71739f2699717b05ba38036b5
https://doi.org/10.1038/s41586-023-06123-3
https://doi.org/10.1038/s41586-023-06123-3
Autor:
Alicia M. Wilson, George A. Poultsides, John R. Bergquist, Brendan C. Visser, Amy Li, Carlos I. Ayala, Monica M. Dua, Jeffrey A. Norton, Amy C. Lu
Publikováno v:
Journal of Surgical Research. 270:195-202
Background Enhanced Recovery After Surgery (ERAS) protocols have been successfully instituted for pancreaticoduodenectomy (PD). This study evaluates reasons patients fail to meet length of stay (LOS) and areas for pathway improvement. Materials and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924b056f09f1ba732176d5e04cb8c349
https://doi.org/10.1016/j.jss.2021.08.034
https://doi.org/10.1016/j.jss.2021.08.034
Autor:
Susan M. Grimes, Heon Seok Kim, Sharmili Roy, Anuja Sathe, Carlos I. Ayala, Alison F. Almeda-Notestine, Sarah Haebe, Tanaya Shree, Ronald Levy, Billy T. Lau, Hanlee P. Ji
In this proof-of-concept study, we developed a single cell method that identifies somatic alterations found in coding regions of mRNAs and integrates these mutation genotypes with their matching cell transcriptomes. We used nanopore adaptive sampling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8df5a8376e4c8a444fc7f04f4a9b71a
https://doi.org/10.1101/2022.11.22.517284
https://doi.org/10.1101/2022.11.22.517284
Autor:
Anuja Sathe, Susan M. Grimes, Hanlee P. Ji, George A. Poultsides, Carlos I. Ayala, Jiamin Chen
Publikováno v:
Cancer Research. 81:1680-1680
The tumor microenvironment (TME) contains diverse cell phenotypes. This heterogeneity influences the cancer immunity cycle and response to immunotherapy. We examined the effects of immunotherapy in a unique patient-derived ex vivo system that maintai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13e962da252e04a5849aefff8eeb3e00
https://doi.org/10.1158/1538-7445.am2021-1680
https://doi.org/10.1158/1538-7445.am2021-1680
Publikováno v:
Journal of Cell Science.
The self-degradative process of autophagy is important for energy homeostasis and cytoplasmic renewal. This lysosome-mediated pathway is negatively regulated by the target of rapamycin kinase (TOR) under basal conditions, and requires the vesicle tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfec96c5337c3836837a50c031e0301f
https://doi.org/10.1242/jcs.216127
https://doi.org/10.1242/jcs.216127
Autor:
Jung Kim, Melissa K. Gardner, Thomas S. Hays, Amanda L. Neisch, Carlos I. Ayala, Christopher R. Braden, Thomas P. Neufeld, Caroline Mauvezin, Abigail Beltrame
Publikováno v:
Journal of Cell Science.
Degradation of cellular material by autophagy is essential for cell survival and homeostasis, and requires intracellular transport of autophagosomes to encounter acidic lysosomes through unknown mechanisms. Here we identify the PX domain-containing k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7645a706fa5bd26cc8d300a98f4c11c9
https://doi.org/10.1242/jcs.175224
https://doi.org/10.1242/jcs.175224
The term autophagy refers to the engulfment and degradation of cytoplasmic components within the lysosome. This process can benefit cells and organisms by removing damaged, superfluous, or harmful cellular components, and by generating a supply of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732d65271bc9c1994c41579f4117c33a
https://europepmc.org/articles/PMC4048785/
https://europepmc.org/articles/PMC4048785/
Publikováno v:
Journal of Health Disparities Research & Practice. 2019Special issue, Vol. 12 Issue 4, p63-63. 1p.