Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Carlos H. Villa"'
Autor:
Ian Kracalik, Alyssa G. Kent, Carlos H. Villa, Paige Gable, Pallavi Annambhotla, Gillian McAllister, Deborah Yokoe, Charles R. Langelier, Kelly Oakeson, Judith Noble-Wang, Orieji Illoh, Alison Laufer Halpin, Anne F. Eder, Sridhar V. Basavaraju
Publikováno v:
Emerging Infectious Diseases, Vol 29, Iss 10, Pp 1979-1989 (2023)
During May 2018‒December 2022, we reviewed transfusion-transmitted sepsis cases in the United States attributable to polymicrobial contaminated apheresis platelet components, including Acinetobacter calcoaceticus‒baumannii complex or Staphylococc
Externí odkaz:
https://doaj.org/article/22513e47652c4f89aae3a2be2cbd34be
Autor:
Jacob S. Brenner, Daniel C. Pan, Jacob W. Myerson, Oscar A. Marcos-Contreras, Carlos H. Villa, Priyal Patel, Hugh Hekierski, Shampa Chatterjee, Jian-Qin Tao, Hamideh Parhiz, Kartik Bhamidipati, Thomas G. Uhler, Elizabeth D. Hood, Raisa Yu. Kiseleva, Vladimir S. Shuvaev, Tea Shuvaeva, Makan Khoshnejad, Ian Johnston, Jason V. Gregory, Joerg Lahann, Tao Wang, Edward Cantu, William M. Armstead, Samir Mitragotri, Vladimir Muzykantov
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Unwanted uptake in the liver and limited accumulation in target organs is a major obstacle to targeted drug delivery. Here, the authors report on the hitchhiking of nanocarriers on red blood cells and the targeted upstream delivery to different targe
Externí odkaz:
https://doaj.org/article/362e0eed733347a8aa0df110774ccc31
Autor:
Carlos H. Villa, Daniel C. Pan, Ian H. Johnston, Colin F. Greineder, Landis R. Walsh, Elizabeth D. Hood, Douglas B. Cines, Mortimer Poncz, Don L. Siegel, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 2, Iss 3, Pp 165-176 (2018)
Abstract: Carriage of drugs by red blood cells (RBCs) modulates pharmacokinetics, pharmacodynamics, and immunogenicity. However, optimal targets for attaching therapeutics to human RBCs and adverse effects have not been studied. We engineered nonhuma
Externí odkaz:
https://doaj.org/article/a2921fc5daff4bd8bbb9bbefa4a0a492
Autor:
Colin F. Greineder, Ian H. Johnston, Carlos H. Villa, Kandace Gollomp, Charles T. Esmon, Douglas B. Cines, Mortimer Poncz, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 1, Iss 18, Pp 1452-1465 (2017)
Abstract: Diverse human illnesses are characterized by loss or inactivation of endothelial thrombomodulin (TM), predisposing to microvascular inflammation, activation of coagulation, and tissue ischemia. Single-chain antibody fragment (scFv)/TM) fusi
Externí odkaz:
https://doaj.org/article/5eaf34428b9e4bf6807c10cf61c2e8ce
Autor:
Patrick M. Glassman, Carlos H. Villa, Anvay Ukidve, Zongmin Zhao, Paige Smith, Samir Mitragotri, Alan J. Russell, Jacob S. Brenner, Vladimir R. Muzykantov
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 440 (2020)
Red blood cells (RBC) have great potential as drug delivery systems, capable of producing unprecedented changes in pharmacokinetics, pharmacodynamics, and immunogenicity. Despite this great potential and nearly 50 years of research, it is only recent
Externí odkaz:
https://doaj.org/article/5d42c92668354cb59734d4c52a279b66
Autor:
Jennifer C. Villa, Danica Chiu, Alissa H. Brandes, Freddy E. Escorcia, Carlos H. Villa, William F. Maguire, Cheng-Jun Hu, Elisa de Stanchina, M. Celeste Simon, Sangram S. Sisodia, David A. Scheinberg, Yue-Ming Li
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1077-1092 (2014)
γ-Secretase is composed of four proteins that are obligatory for protease activity: presenilin, nicastrin, Aph1, and Pen-2. Despite the progress toward understanding the function of these individual subunits, there is no information available pertai
Externí odkaz:
https://doaj.org/article/6ceae860ea3b4e31a5527f0d58cad229
Autor:
Patrick M. Glassman, Carlos H. Villa, Oscar A. Marcos-Contreras, Elizabeth D. Hood, Landis R. Walsh, Colin F. Greineder, Jacob W. Myerson, Tea Shuvaeva, Laura Puentes, Jacob S. Brenner, Don L. Siegel, Vladimir R. Muzykantov
Publikováno v:
Bioconjugate Chemistry. 33:1286-1294
Engineering drug delivery systems for prolonged pharmacokinetics (PK) has been an ongoing pursuit for nearly 50 years. The gold standard for PK enhancement is the coating of nanoparticles with polymers, namely polyethylene glycol (PEGylation), which
Autor:
David A. Scheinberg, Robert Benezra, Ronald G. Blasberg, Peter Smith-Jones, Carlos H. Villa, Michael R. McDevitt, Erik Henke, Freddy E. Escorcia
Supplementary Methods, Figures 1-3 from Selective Killing of Tumor Neovasculature Paradoxically Improves Chemotherapy Delivery to Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744e274e0b77f8de873badc578ddb575
https://doi.org/10.1158/0008-5472.22384244.v1
https://doi.org/10.1158/0008-5472.22384244.v1
Autor:
Vladimir R. Muzykantov, Anna D. Protopopova, J. Eric Russell, John W. Weisel, Carlos H. Villa, Rustem I. Litvinov, David R. Myers, Wilbur A. Lam, Chandrasekaran Nagaswami, Valerie Tutwiler, Don L. Siegel, Osheiza Abdulmalik, Eric Woods
Publikováno v:
J Thromb Haemost
BACKGROUND: Blood clot contraction, volume shrinkage of the clot, is driven by platelet contraction and accompanied by compaction of the erythrocytes and their gradual shape change from biconcave to polyhedral, with the resulting cells named polyhedr
Autor:
Laura T. Ferguson, Elizabeth D. Hood, Tea Shuvaeva, Vladimir V. Shuvaev, Maria C. Basil, Zhicheng Wang, Jia Nong, Xiaonan Ma, Jichuan Wu, Jacob W. Myerson, Oscar A. Marcos-Contreras, Jeremy Katzen, Justine M. Carl, Edward E. Morrisey, Edward Cantu, Carlos H. Villa, Samir Mitragotri, Vladimir R. Muzykantov, Jacob S. Brenner
Publikováno v:
ACS Nano
A long-standing goal of nanomedicine is to improve a drug’s benefit by loading it into a nanocarrier that homes solely to a specific target cell and organ. Unfortunately, nanocarriers usually end up with only a small percentage of the injected dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27890969e38ca28d17e3ff872c3569de
https://europepmc.org/articles/PMC9339245/
https://europepmc.org/articles/PMC9339245/