Výsledky vyhledávání - "Carlos H. Vieira-Vieira"

Akademický článek

Cryo-EM captures early ribosome assembly in action

Autor: Bo Qin, Simon M. Lauer, Annika Balke, Carlos H. Vieira-Vieira, Jörg Bürger, Thorsten Mielke, Matthias Selbach, Patrick Scheerer, Christian M. T. Spahn, Rainer Nikolay

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)

The production of ribosomes is a precisely orchestrated energy consuming cellular process of highest priority. Here, the authors use cryo-EM to show that bacterial ribosomal subunits, self-assembled from their purified RNA and protein components, mat

Externí odkaz: https://doaj.org/article/7f05dc87951a42e88a650b99b95bd061

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Akademický článek

HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins

Autor: Ulrike Zinnall, Miha Milek, Igor Minia, Carlos H. Vieira-Vieira, Simon Müller, Guido Mastrobuoni, Orsalia-Georgia Hazapis, Simone Del Giudice, David Schwefel, Nadine Bley, Franka Voigt, Jeffrey A. Chao, Stefan Kempa, Stefan Hüttelmaier, Matthias Selbach, Markus Landthaler

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)

RNA binding protein HDLBP (or Vigilin) localizes in the endoplasmic reticulum (ER) membrane. Here the authors show that HDLBP contributes to translation of ER-targeted mRNAs.

Externí odkaz: https://doaj.org/article/540eabd8ef794660a1b89d9588fee403

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Akademický článek

Purification of cross-linked RNA-protein complexes by phenol-toluol extraction

Autor: Erika C. Urdaneta, Carlos H. Vieira-Vieira, Timon Hick, Hans-Herrmann Wessels, Davide Figini, Rebecca Moschall, Jan Medenbach, Uwe Ohler, Sander Granneman, Matthias Selbach, Benedikt M. Beckmann

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

RNA binding proteins are important regulators of RNA function. Here the authors describe a method for isolation of RNA-protein complexes that does not rely on a specific RNA sequence or motif, and demonstrate the approach by providing the global RNA-

Externí odkaz: https://doaj.org/article/4c172901827e4b4c9950ae7fba3c2b89

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Akademický článek

Opportunities and Challenges in Global Quantification of RNA-Protein Interaction via UV Cross-Linking

Autor: Carlos H. Vieira-Vieira, Matthias Selbach

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

RNA-binding proteins (RBPs) are key mediators of posttranscriptional gene expression control. However, the links between cell signaling on the one hand and RBP function on the other are understudied. While thousands of posttranslational modification

Externí odkaz: https://doaj.org/article/53a24504b7124457906f31b61b798d57

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Time-resolved cryo-EM reveals early ribosome assembly in action

Autor: Bo Qin, Simon M. Lauer, Annika Balke, Carlos H. Vieira-Vieira, Jörg Bürger, Thorsten Mielke, Matthias Selbach, Patrick Scheerer, Christian M. T. Spahn, Rainer Nikolay

Ribosome biogenesis is a fundamental multi-step cellular process in all domains of life that involves the production, processing, folding, and modification of ribosomal RNAs (rRNAs) and ribosomal proteins. To obtain insights into the still unexplored

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f57f4dda8cb83526b3f939baceeae40
https://doi.org/10.1101/2022.11.12.516267

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Proteome-wide quantitative RNA interactome capture (qRIC) identifies phosphorylation sites with regulatory potential in RBM20

Autor: Michael Gotthardt, Carlos H. Vieira-Vieira, Matthias Selbach, Vita Dauksaite

SummaryRNA-binding proteins (RBPs) are major regulators of gene expression at the post-transcriptional level. While many posttranslational modification sites in RBPs have been identified, little is known about how these modifications regulate RBP fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88abccd38ec07dfca2acaa4b69f1a0c0
https://doi.org/10.1101/2021.07.12.452044

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HDLBP binds ER-targeted mRNAs by multivalent interactions to promote protein synthesis of transmembrane and secreted proteins

Publikováno v: Nature communications. 13(1)

The biological role of RNA-binding proteins in the secretory pathway is not well established. Here, we describe that human HDLBP/Vigilin directly interacts with more than 80% of ER-localized mRNAs. PAR-CLIP analysis reveals that these transcripts rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4395dc5f0698ebfa7f4e384696eba1
https://pubmed.ncbi.nlm.nih.gov/35585045

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OUP accepted manuscript

Publikováno v: Human Molecular Genetics.

Primary autosomal recessive microcephaly and Seckel syndrome spectrum disorders (MCPH-SCKS) include a heterogeneous group of autosomal recessive inherited diseases characterized by primary (congenital) microcephaly, the absence of visceral abnormalit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc21b12d915fc61434d361bca0460169
https://doi.org/10.1093/hmg/ddab160

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