Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Carlos Gerngroß"'
Autor:
Peter Herhaus, Stefan Habringer, Tibor Vag, Katja Steiger, Julia Slotta-Huspenina, Carlos Gerngroß, Benedikt Wiestler, Hans-Jürgen Wester, Markus Schwaiger, Ulrich Keller
Publikováno v:
EJNMMI Research, Vol 7, Iss 1, Pp 1-4 (2017)
Abstract CXCR4 belongs to the family of chemokine receptors. Together with its sole known ligand CXCL12 (SDF-1alpha), it has a pivotal role during organogenesis and for homing of hematopoietic stem cells. CXCR4 is overexpressed in various malignancie
Externí odkaz:
https://doaj.org/article/d27fa8ca46b04e728ce4fb19001f868c
Autor:
Kathrin Philipp‐Abbrederis, Ken Herrmann, Stefan Knop, Margret Schottelius, Matthias Eiber, Katharina Lückerath, Elke Pietschmann, Stefan Habringer, Carlos Gerngroß, Katharina Franke, Martina Rudelius, Andreas Schirbel, Constantin Lapa, Kristina Schwamborn, Sabine Steidle, Elena Hartmann, Andreas Rosenwald, Saskia Kropf, Ambros J Beer, Christian Peschel, Hermann Einsele, Andreas K Buck, Markus Schwaiger, Katharina Götze, Hans‐Jürgen Wester, Ulrich Keller
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 4, Pp 477-487 (2015)
Abstract CXCR4 is a G‐protein‐coupled receptor that mediates recruitment of blood cells toward its ligand SDF‐1. In cancer, high CXCR4 expression is frequently associated with tumor dissemination and poor prognosis. We evaluated the novel CXCR4
Externí odkaz:
https://doaj.org/article/b94bc3fe20304d139146df2d3df76b5d
Autor:
Peter Herhaus, Stefan Habringer, Kathrin Philipp-Abbrederis, Tibor Vag, Carlos Gerngross, Margret Schottelius, Julia Slotta-Huspenina, Katja Steiger, Torben Altmann, Tanja Weißer, Sabine Steidle, Markus Schick, Laura Jacobs, Jolanta Slawska, Catharina Müller-Thomas, Mareike Verbeek, Marion Subklewe, Christian Peschel, Hans-Jürgen Wester, Markus Schwaiger, Katharina Götze, Ulrich Keller
Publikováno v:
Haematologica, Vol 101, Iss 8 (2016)
Acute myeloid leukemia originates from leukemia-initiating cells that reside in the protective bone marrow niche. CXCR4/CXCL12 interaction is crucially involved in recruitment and retention of leukemia-initiating cells within this niche. Various drug
Externí odkaz:
https://doaj.org/article/aea51815605e4cdeb5c6de70fdf59817
Autor:
Michael Quante, Timothy C. Wang, Hans-Jürgen Wester, Antonia R. Sepulveda, Anja A. Kühl, Wilko Weichert, Moritz Jesinghaus, Carlos Gerngroß, Katja Steiger, Gabriele Multhoff, Stefan Stangl, Michael Schauer, Haibo Liu, Jonas Ingermann, Margret Schottelius, Natasha Stephens Münch, Hsin-Yu Fang
(a) Gating example of flow cytometric analysis for CXCR4+CD45+CD11b+ myeloid cells, neutrophils (CD45+CD11b+Ly6G+F480-.), and macrophages (CD45+CD11b+Ly6G-F480+). (b-d) Flow cytometric analysis of ILCs (CD45+Cd3-Cd90.2+), NK cells (CD45+CD3-NK1.1+) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e352f02048a22923fd4883e87b53f6e
https://doi.org/10.1158/1078-0432.22464863
https://doi.org/10.1158/1078-0432.22464863
Autor:
Michael Quante, Timothy C. Wang, Hans-Jürgen Wester, Antonia R. Sepulveda, Anja A. Kühl, Wilko Weichert, Moritz Jesinghaus, Carlos Gerngroß, Katja Steiger, Gabriele Multhoff, Stefan Stangl, Michael Schauer, Haibo Liu, Jonas Ingermann, Margret Schottelius, Natasha Stephens Münch, Hsin-Yu Fang
A trend appears that more CXCR4+proliferating cells are present in high-grade dysplasia mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e016ce443854afd591750a505681c664
https://doi.org/10.1158/1078-0432.22464860
https://doi.org/10.1158/1078-0432.22464860
Autor:
Michael Quante, Timothy C. Wang, Hans-Jürgen Wester, Antonia R. Sepulveda, Anja A. Kühl, Wilko Weichert, Moritz Jesinghaus, Carlos Gerngroß, Katja Steiger, Gabriele Multhoff, Stefan Stangl, Michael Schauer, Haibo Liu, Jonas Ingermann, Margret Schottelius, Natasha Stephens Münch, Hsin-Yu Fang
Purpose: Barrett's esophagus represents an early stage in carcinogenesis leading to esophageal adenocarcinoma. Considerable evidence supports a major role for chronic inflammation and diverse chemokine pathways in the development of Barrett's esophag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91e7808aa9255158c95ca104bb3e28c
https://doi.org/10.1158/1078-0432.c.6525836.v1
https://doi.org/10.1158/1078-0432.c.6525836.v1
Autor:
Michael Quante, Timothy C. Wang, Hans-Jürgen Wester, Antonia R. Sepulveda, Anja A. Kühl, Wilko Weichert, Moritz Jesinghaus, Carlos Gerngroß, Katja Steiger, Gabriele Multhoff, Stefan Stangl, Michael Schauer, Haibo Liu, Jonas Ingermann, Margret Schottelius, Natasha Stephens Münch, Hsin-Yu Fang
CXCR4 immunohistochemistry of a patient with EAC that has been imaged by [68Ga]CXCR4-PET/CT showing moderate infiltration with immune cells (open arrow) expressing CXCR4. Only very few epithelial tumor cells were detectable within this biopsy and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ba6ac8fcf3aa4a9e29b75a7ee7c1e2
https://doi.org/10.1158/1078-0432.22464857.v1
https://doi.org/10.1158/1078-0432.22464857.v1
Autor:
Margret Schottelius, Anja A. Kühl, Wilko Weichert, Timothy C. Wang, Gabriele Multhoff, Hans-Jürgen Wester, Carlos Gerngroß, Natasha Stephens Münch, Jonas Ingermann, Moritz Jesinghaus, Antonia R. Sepulveda, Haibo Liu, Hsin-Yu Fang, Stefan Stangl, Michael Quante, Michael Schauer, Katja Steiger
Publikováno v:
Clinical Cancer Research. 24:1048-1061
Purpose: Barrett's esophagus represents an early stage in carcinogenesis leading to esophageal adenocarcinoma. Considerable evidence supports a major role for chronic inflammation and diverse chemokine pathways in the development of Barrett's esophag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::279dec3ea5bb56c13dd1744a6f88d304
https://doi.org/10.1158/1078-0432.ccr-17-1756
https://doi.org/10.1158/1078-0432.ccr-17-1756
Publikováno v:
Journal of Nuclear Medicine. 58:1104-1110
Brown adipose tissue (BAT) provides a means of nonshivering thermogenesis. In humans, active BAT can be visualized by 18F-FDG uptake as detected by PET combined with CT. The retrospective analysis of clinical scans is a valuable source to identify an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7236aa08015e31eb322061ad649141cc
https://doi.org/10.2967/jnumed.116.183988
https://doi.org/10.2967/jnumed.116.183988
Autor:
Kathrin Philipp-Abbrederis, Markus Schwaiger, Peter Herhaus, Frank-Philipp Graner, Ulrich Keller, Matthias Eiber, Hans-Jürgen Wester, Tibor Vag, Johannes Ettl, Carlos Gerngross
Publikováno v:
Journal of Nuclear Medicine. 57:741-746
CXCR4 is a chemokine receptor that is overexpressed in various human cancers and is involved in tumor metastasis. The aim of this proof-of-concept study was to evaluate a novel CXCR4-targeted PET probe in patients with solid cancers with reported in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1682eca4e1f379bdb555a922c1cbb0
https://doi.org/10.2967/jnumed.115.161034
https://doi.org/10.2967/jnumed.115.161034