Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Carlos García-Crespo"'
Autor:
Brenda Martínez-González, María Eugenia Soria, Pablo Mínguez, Ramón Lorenzo-Redondo, Llanos Salar-Vidal, Alberto López-García, Mario Esteban-Muñoz, Antoni Durán-Pastor, Pilar Somovilla, Carlos García-Crespo, Ana Isabel de Ávila, Jordi Gómez, Jaime Esteban, Ricardo Fernández-Roblas, Ignacio Gadea, Esteban Domingo, Celia Perales
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionSARS-CoV-2 isolates of a given clade may contain low frequency genomes that encode amino acids or deletions which are typical of a different clade.MethodsHere we use high resolution ultra-deep sequencing to analyze SARS-CoV-2 mutant spect
Externí odkaz:
https://doaj.org/article/2458e84b3aad42eba6e7b16a7f27dfbb
Autor:
Carlos García-Crespo, Irene Francisco-Recuero, Isabel Gallego, Marina Camblor-Murube, María Eugenia Soria, Ana López-López, Ana Isabel de Ávila, Antonio Madejón, Javier García-Samaniego, Esteban Domingo, Aurora Sánchez-Pacheco, Celia Perales
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionCellular epigenetic modifications occur in the course of viral infections. We previously documented that hepatitis C virus (HCV) infection of human hepatoma Huh-7.5 cells results in a core protein-mediated decrease of Aurora kinase B (AUR
Externí odkaz:
https://doaj.org/article/b3cc1a83b8ad4731aee542b53c738838
Autor:
Carlos García-Crespo, Lucía Vázquez-Sirvent, Pilar Somovilla, María Eugenia Soria, Isabel Gallego, Ana Isabel de Ávila, Brenda Martínez-González, Antoni Durán-Pastor, Esteban Domingo, Celia Perales
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
We report a quantification of the decrease of effectiveness of antiviral agents directed to hepatitis C virus, when the agents are added during an ongoing infection in cell culture vs. when they are added at the beginning of the infection. Major dete
Externí odkaz:
https://doaj.org/article/73c6d82bbe8845b18dff3ceda6ce6cbc
Autor:
Brenda Martínez-González, Lucía Vázquez-Sirvent, María E. Soria, Pablo Mínguez, Llanos Salar-Vidal, Carlos García-Crespo, Isabel Gallego, Ana I. de Ávila, Carlos Llorens, Beatriz Soriano, Ricardo Ramos-Ruiz, Jaime Esteban, Ricardo Fernandez-Roblas, Ignacio Gadea, Carmen Ayuso, Javier Ruíz-Hornillos, Concepción Pérez-Jorge, Esteban Domingo, Celia Perales
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Replication of SARS-CoV-2 in the human population is defined by distributions of mutants that are present at different frequencies within the infected host and can be detected by ultra-deep sequencing techniques. In this study, we examined the SARS-C
Externí odkaz:
https://doaj.org/article/a4878f2c6b334c20baf2fe61091dfbe2
SARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease Outcomes
Autor:
Brenda Martínez-González, María Eugenia Soria, Lucía Vázquez-Sirvent, Cristina Ferrer-Orta, Rebeca Lobo-Vega, Pablo Mínguez, Lorena de la Fuente, Carlos Llorens, Beatriz Soriano, Ricardo Ramos, Marta Cortón, Rosario López-Rodríguez, Carlos García-Crespo, Isabel Gallego, Ana Isabel de Ávila, Jordi Gómez, Luis Enjuanes, Llanos Salar-Vidal, Jaime Esteban, Ricardo Fernandez-Roblas, Ignacio Gadea, Carmen Ayuso, Javier Ruíz-Hornillos, Nuria Verdaguer, Esteban Domingo, Celia Perales
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Mutant spectra of RNA viruses are important to understand viral pathogenesis and response to selective pressures. There is a need to characterize the complexity of mutant spectra in coronaviruses sampled from infected patients. In particular
Externí odkaz:
https://doaj.org/article/6d9736d4a3d14394be76e5f75a5176ca
Autor:
Soledad Delgado, Celia Perales, Carlos García-Crespo, María Eugenia Soria, Isabel Gallego, Ana Isabel de Ávila, Brenda Martínez-González, Lucía Vázquez-Sirvent, Cecilio López-Galíndez, Federico Morán, Esteban Domingo
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT RNA viruses replicate as complex mutant spectra termed viral quasispecies. The frequency of each individual genome in a mutant spectrum depends on its rate of generation and its relative fitness in the replicating population ensemble. The ad
Externí odkaz:
https://doaj.org/article/041d5980a232449789212264732757dd
Autor:
Rosario Sabariegos, Laura Albentosa-González, Blanca Palmero, Pilar Clemente-Casares, Eugenio Ramírez, Carlos García-Crespo, Isabel Gallego, Ana Isabel de Ávila, Celia Perales, Esteban Domingo, Antonio Mas
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Hepatitis C virus (HCV) is a single-stranded RNA virus of positive polarity [ssRNA(+)] that replicates its genome through the activity of one of its proteins, called NS5B. This viral protein is responsible for copying the positive-polarity RNA genome
Externí odkaz:
https://doaj.org/article/7e93660b90394470ad74cb791ef93d3e
Autor:
Brenda Martínez-González, María Eugenia Soria, Lucía Vázquez-Sirvent, Cristina Ferrer-Orta, Rebeca Lobo-Vega, Pablo Mínguez, Lorena de la Fuente, Carlos Llorens, Beatriz Soriano, Ricardo Ramos-Ruíz, Marta Cortón, Rosario López-Rodríguez, Carlos García-Crespo, Pilar Somovilla, Antoni Durán-Pastor, Isabel Gallego, Ana Isabel de Ávila, Soledad Delgado, Federico Morán, Cecilio López-Galíndez, Jordi Gómez, Luis Enjuanes, Llanos Salar-Vidal, Mario Esteban-Muñoz, Jaime Esteban, Ricardo Fernández-Roblas, Ignacio Gadea, Carmen Ayuso, Javier Ruíz-Hornillos, Nuria Verdaguer, Esteban Domingo, Celia Perales
Publikováno v:
Pathogens, Vol 11, Iss 6, p 662 (2022)
Populations of RNA viruses are composed of complex and dynamic mixtures of variant genomes that are termed mutant spectra or mutant clouds. This applies also to SARS-CoV-2, and mutations that are detected at low frequency in an infected individual ca
Externí odkaz:
https://doaj.org/article/1a2a6aef651b4189a3f7cf754f253bd4
Publikováno v:
Viruses, Vol 13, Iss 9, p 1882 (2021)
The error rate displayed during template copying to produce viral RNA progeny is a biologically relevant parameter of the replication complexes of viruses. It has consequences for virus–host interactions, and it represents the first step in the div
Externí odkaz:
https://doaj.org/article/9243b0e9000f4ef088731b8a3c6b8983
Autor:
Carlos García-Crespo, Isabel Gallego, María Eugenia Soria, Ana Isabel de Ávila, Brenda Martínez-González, Lucía Vázquez-Sirvent, Rebeca Lobo-Vega, Elena Moreno, Jordi Gómez, Carlos Briones, Josep Gregori, Josep Quer, Esteban Domingo, Celia Perales
Publikováno v:
Viruses, Vol 13, Iss 4, p 616 (2021)
Replication of RNA viruses is characterized by exploration of sequence space which facilitates their adaptation to changing environments. It is generally accepted that such exploration takes place mainly in response to positive selection, and that fu
Externí odkaz:
https://doaj.org/article/814414a9f9ba4609b11b9c04f46cf904