Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Carlos G. Dotti"'
Autor:
Marta Carús-Cadavieco, Sandra González de la Fuente, Inés Berenguer López, Miguel A. Serrano-Lope, Begoña Aguado, Francesc Guix, Ernest Palomer, Carlos G. Dotti
Publikováno v:
Nutrition & Diabetes, Vol 14, Iss 1, Pp 1-6 (2024)
Abstract Analyzing changes in gene expression within specific brain regions of individuals with Type 2 Diabetes (T2DM) who do not exhibit significant cognitive deficits can yield valuable insights into the mechanisms underlying the progression toward
Externí odkaz:
https://doaj.org/article/70cd37f4b7fb459896f3bbf948cdd13b
Autor:
Mauricio G. Martín, Carlos G. Dotti
Publikováno v:
Pharmacological Research, Vol 194, Iss , Pp 106879- (2023)
Externí odkaz:
https://doaj.org/article/4299ac0c95c44ad1bcffaa9f642f2178
Autor:
Mauricio G. Martín, Carlos G. Dotti
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
One of the characteristics of aging is a gradual hypo-responsiveness of cells to extrinsic stimuli, mainly evident in the pathways that are under hormone control, both in the brain and in peripheral tissues. Age-related resistance, i.e., reduced resp
Externí odkaz:
https://doaj.org/article/86b9a8baf1934785a055fc95c2e8ea68
Autor:
Álvaro Casadomé-Perales, Sara Naya, Elisa Fernández-Martínez, Bea G. Mille, Marta Guerrero-Valero, Héctor Peinado, Francesc X. Guix, Carlos G. Dotti, Ernest Palomer
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5986 (2023)
Ageing is associated with notorious alterations in neurons, i.e., in gene expression, mitochondrial function, membrane degradation or intercellular communication. However, neurons live for the entire lifespan of the individual. One of the reasons why
Externí odkaz:
https://doaj.org/article/d0efd33f36e74584bf1203b371322caa
Autor:
Silvia de Vidania, Irene Palomares-Perez, Ana Frank-García, Takashi Saito, Takaomi C. Saido, Jonathan Draffin, María Szaruga, Lucía Chávez-Gutierrez, Miguel Calero, Miguel Medina, Francesc X. Guix, Carlos G. Dotti
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
In humans, a considerable number of the autopsy samples of cognitively normal individuals aged between 57 and 102 years have revealed the presence of amyloid plaques, one of the typical signs of AD, indicating that many of us use mechanisms that defe
Externí odkaz:
https://doaj.org/article/b8f75df402f046f794db3d97e1ac37b1
Autor:
Daniel Almansa, Héctor Peinado, Raquel García-Rodríguez, Álvaro Casadomé-Perales, Carlos G. Dotti, Francesc X. Guix
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1371 (2022)
Extracellular vesicles (EVs) play an important role in intercellular communication and are involved in both physiological and pathological processes. In the central nervous system (CNS), EVs secreted from different brain cell types exert a sundry of
Externí odkaz:
https://doaj.org/article/82ca0e5b18bb4f00aaaa32c9ae8aad49
Autor:
Isabel H. Salas, Akila Weerasekera, Tariq Ahmed, Zsuzsanna Callaerts-Vegh, Uwe Himmelreich, Rudi D'Hooge, Detlef Balschun, Takaomi C. Saido, Bart De Strooper, Carlos G. Dotti
Publikováno v:
Neurobiology of Disease, Vol 113, Iss , Pp 82-96 (2018)
Type 2 diabetes (T2DM) and obesity might increase the risk for AD by 2-fold. Different attempts to model the effect of diet-induced diabetes on AD pathology in transgenic animal models, resulted in opposite conclusions. Here, we used a novel knock-in
Externí odkaz:
https://doaj.org/article/c03c28b61bb84166ae5f8f5a7191241f
Autor:
Adrián Martín-Segura, Álvaro Casadomé-Perales, Pietro Fazzari, José Manuel Mas, Laura Artigas, Raquel Valls, Angel R. Nebreda, Carlos G. Dotti
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Numerous studies suggest that the increased activity of p38MAPK plays an important role in the abnormal immune and inflammatory response observed in the course of neurodegenerative diseases such as Alzheimer's disease. On the other hand, high levels
Externí odkaz:
https://doaj.org/article/51d53101edb548d5bfcae6feb9c2312e
Autor:
Francesc X Guix, Carlos G Dotti
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 1, Pp 7-9 (2017)
Abstract In a most simplified way, we can say that much of the symptomatology that characterizes Alzheimer's disease (AD) can be attributed to a cascade of toxic events initiated by the presence in the interstitial space of the brain of oligomers of
Externí odkaz:
https://doaj.org/article/0afb85dca04e4d3b8b6d9e99789e7ba0
Autor:
Ernest Palomer, Adrián Martín-Segura, Shishir Baliyan, Tariq Ahmed, Detlef Balschun, Cesar Venero, Mauricio G. Martin, Carlos G. Dotti
Publikováno v:
Cell Reports, Vol 16, Iss 11, Pp 2889-2900 (2016)
Cognitive capacities decline with age, an event accompanied by the altered transcription of synaptic plasticity genes. Here, we show that the transcriptional induction of Bdnf by a mnemonic stimulus is impaired in aged hippocampal neurons. Mechanisti
Externí odkaz:
https://doaj.org/article/3e0c2effd8d543e2bf27330e30d4a84e