Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Carlos G Vanoye"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1010038 (2022)
Recent advances in experimental and computational protein structure determination have provided access to high-quality structures for most human proteins and mutants thereof. However, linking changes in structure in protein mutants to functional impa
Externí odkaz:
https://doaj.org/article/1f65416cef8842b48e5fb3c0a0a06b46
Autor:
Dina Simkin, Kelly A Marshall, Carlos G Vanoye, Reshma R Desai, Bernabe I Bustos, Brandon N Piyevsky, Juan A Ortega, Marc Forrest, Gabriella L Robertson, Peter Penzes, Linda C Laux, Steven J Lubbe, John J Millichap, Alfred L George Jr, Evangelos Kiskinis
Publikováno v:
eLife, Vol 10 (2021)
Mutations in KCNQ2, which encodes a pore-forming K+ channel subunit responsible for neuronal M-current, cause neonatal epileptic encephalopathy, a complex disorder presenting with severe early-onset seizures and impaired neurodevelopment. The conditi
Externí odkaz:
https://doaj.org/article/77a9457c95724ba991f9276aa4d1ab55
Autor:
Georg Kuenze, Carlos G Vanoye, Reshma R Desai, Sneha Adusumilli, Kathryn R Brewer, Hope Woods, Eli F McDonald, Charles R Sanders, Alfred L George Jr, Jens Meiler
Publikováno v:
eLife, Vol 9 (2020)
The function of the voltage-gated KCNQ1 potassium channel is regulated by co-assembly with KCNE auxiliary subunits. KCNQ1-KCNE1 channels generate the slow delayed rectifier current, IKs, which contributes to the repolarization phase of the cardiac ac
Externí odkaz:
https://doaj.org/article/eb5503437d7d4717b295c6786fb43fec
Autor:
Georg Kuenze, Amanda M Duran, Hope Woods, Kathryn R Brewer, Eli Fritz McDonald, Carlos G Vanoye, Alfred L George, Charles R Sanders, Jens Meiler
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0220415 (2019)
The voltage-gated potassium channel KCNQ1 (KV7.1) assembles with the KCNE1 accessory protein to generate the slow delayed rectifier current, IKS, which is critical for membrane repolarization as part of the cardiac action potential. Loss-of-function
Externí odkaz:
https://doaj.org/article/34428767e7f74f1ab409652801eb3dd6
Autor:
Xinghang Jiang, Olivia T. Ly, Hanna Chen, Ziwei Zhang, Beatriz A. Ibarra, Mahmud A. Pavel, Grace E. Brown, Arvind Sridhar, David Tofovic, Abigail Swick, Richard Marszalek, Carlos G. Vanoye, Fritz Navales, Alfred L. George, Jr., Salman R. Khetani, Jalees Rehman, Yu Gao, Dawood Darbar, Ankur Saxena
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110395- (2024)
Summary: Developmental causes of the most common arrhythmia, atrial fibrillation (AF), are poorly defined, with compensation potentially masking arrhythmic risk. Here, we delete 9 amino acids (Δ9) within a conserved domain of the giant protein titin
Externí odkaz:
https://doaj.org/article/489be31f1fb44db7b69aaaf61e69c5c9
Autor:
K. Ashley Fetterman, Malorie Blancard, Davi M. Lyra-Leite, Carlos G. Vanoye, Hananeh Fonoudi, Mariam Jouni, Jean-Marc L. DeKeyser, Brian Lenny, Yadav Sapkota, Alfred L. George, Jr., Paul W. Burridge
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114160- (2024)
Summary: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) recapitulate numerous disease and drug response phenotypes, but cell immaturity may limit their accuracy and fidelity as a model system. Cell culture medium modification
Externí odkaz:
https://doaj.org/article/df419155f7fa4cacb87f83b0c98d9bc2
Autor:
Kathryn R. Brewer, Georg Kuenze, Carlos G. Vanoye, Alfred L. George, Jens Meiler, Charles R. Sanders
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The cardiac action potential is critical to the production of a synchronized heartbeat. This electrical impulse is governed by the intricate activity of cardiac ion channels, among them the cardiac voltage-gated potassium (Kv) channels KCNQ1 and hERG
Externí odkaz:
https://doaj.org/article/9513fb6290644222a02f780f87dc44b7
Autor:
Abdelhak Belamadni, Dongjun Ren, Nirupa Jayaraj, Richard J. Miller, Carlos G. Vanoye, Alfred L. George, Daniela M. Menichella
Publikováno v:
The Journal of Pain. 24:4-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b59df46c7895a5b84ec0431cc696acaa
https://doi.org/10.1016/j.jpain.2023.02.017
https://doi.org/10.1016/j.jpain.2023.02.017
Autor:
Georg Kuenze, Carlos G. Vanoye, Mason C. Wilkinson, Reshma R. Desai, Sneha Adusumilli, Charles R. Sanders, Alfred L. George, Jens Meiler
The voltage-gated potassium channel KCNQ1 (KV7.1) is important for the repolarizing phase of the cardiac action potential. Activators of KCNQ1 may provide a strategy for the pharmacological treatment of congenital long QT syndrome, a genetic disorder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ddb51d78639b0d4eb552b681ceef5e0
https://doi.org/10.1101/2022.05.31.494217
https://doi.org/10.1101/2022.05.31.494217
Autor:
Z. Ji, E. Fitch, N. Ghabra, J. Nishtha, Dianalee McKnight, Ingo Helbig, Amanda Lindy, Edward C. Cooper, N. Jairam, Alfred L. George, Sneha Adusumilli, F. Zou, Carlos G. Vanoye, Reshma R. Desai, Kimberly Helbig
Publikováno v:
JCI Insight. 7
Hundreds of KCNQ2 variants have been identified by genetic testing of children with early onset epilepsy and/or developmental disability. Voltage-clamp recording from heterologous cells has proved useful for establishing deleterious functional effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a2b04e6b56b3728567dadde584236f
https://doi.org/10.1172/jci.insight.156314
https://doi.org/10.1172/jci.insight.156314