Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Carlos Fernandez‐Patron"'
Autor:
Faraz S. Hussain, Ramanaguru S. Piragasam, Hassan Sarker, Derrick Blackmore, Elaine Yacyshyn, Carlos Fernandez-Patron, Richard P. Fahlman, Zaeem A. Siddiqi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Myasthenia Gravis (MG) is an autoimmune disease associated with severe neuromuscular weakness. Diagnostic confirmation of MG is typically delayed and secured in about 85% and 50% of patients with generalized and ocular MG, respectively with
Externí odkaz:
https://doaj.org/article/528713063f13476c8e161b56fb4f1514
Publikováno v:
Cells, Vol 12, Iss 13, p 1699 (2023)
We advance the notion that much like artificial nanoparticles, relatively more complex biological entities with nanometric dimensions such as pathogens (viruses, bacteria, and other microorganisms) may also acquire a biomolecular corona upon entering
Externí odkaz:
https://doaj.org/article/fca08cbd00ae4541a53c1153e894f3f6
Autor:
Hassan Sarker, Rashmi Panigrahi, Eugenio Hardy, J. N. Mark Glover, Shokrollah Elahi, Carlos Fernandez-Patron
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Dexamethasone may reduce mortality in COVID-19 patients. Whether dexamethasone or endogenous glucocorticoids, such as cortisol, biochemically interact with SARS-CoV-2 spike 1 protein (S1), or its cellular receptor ACE2, is unknown. Using molecular dy
Externí odkaz:
https://doaj.org/article/be11089b18fa4f2a9f1e7f6b349437a0
Autor:
Eugenio Hardy, Carlos Fernandez-Patron
Publikováno v:
Cells, Vol 11, Iss 19, p 2955 (2022)
Endogenous glucocorticoids and their synthetic analogues, such as dexamethasone, stimulate receptor-mediated signal transduction mechanisms on target cells. Some of these mechanisms result in beneficial outcomes whereas others are deleterious in the
Externí odkaz:
https://doaj.org/article/a0862a42b82841c6bbb7978fe52c2ef3
Autor:
Carlos Fernandez-Patron, Eugenio Hardy
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 692 (2022)
Much has been written about matrix metalloproteinases (MMPs) in health and disease conditions, but their roles in the setting of COVID-19 and associated illnesses remain understudied [...]
Externí odkaz:
https://doaj.org/article/37843942633f43aaaf4dd0ba15ae0c5c
Autor:
Hassan Sarker, Eugenio Hardy, Ayman Haimour, Mahmoud A. Karim, Sabine Scholl-Bürgi, John A. Martignetti, Lorenzo D. Botto, Carlos Fernandez-Patron
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Deficiency of matrix metalloproteinase 2 (MMP-2) causes a complex syndrome characterized by multicentric osteolysis, nodulosis, and arthropathy (MONA) as well as cardiac valve defects, dwarfism and hirsutism. MMP-2 deficient (Mmp2–/–) mice are a
Externí odkaz:
https://doaj.org/article/f6b97806d45d42d3941163ee1c6bf138
Autor:
Eugenio Hardy, Carlos Fernandez-Patron
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Bone is a dynamic organ that undergoes constant remodeling, an energetically costly process by which old bone is replaced and localized bone defects are repaired to renew the skeleton over time, thereby maintaining skeletal health. This review provid
Externí odkaz:
https://doaj.org/article/cd2a86335f8f4c53ba41d3daa0d63c8a
Autor:
Siva S. V. P. Sakamuri, Russell Watts, Abhijit Takawale, Xiuhua Wang, Samuel Hernandez-Anzaldo, Wesam Bahitham, Carlos Fernandez-Patron, Richard Lehner, Zamaneh Kassiri
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Tissue inhibitor of metalloproteases (TIMPs) are inhibitors of matrix metalloproteinases (MMPs) that regulate tissue extracellular matrix (ECM) turnover. TIMP4 is highly expressed in adipose tissue, its levels are further elevated following
Externí odkaz:
https://doaj.org/article/fa68f747eb244e7984495198cb3a085e
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 578 (2021)
Matrix metalloproteinases (MMPs) cleave extracellular matrix proteins, growth factors, cytokines, and receptors to influence organ development, architecture, function, and the systemic and cell-specific responses to diseases and pharmacological drugs
Externí odkaz:
https://doaj.org/article/28cd06ee63ff4df1a08e18aa23354dd2
Autor:
Eugenio Hardy, Carlos Fernandez-Patron
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 390 (2021)
Many individuals infected with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) develop no or only mild symptoms, but some can go on onto develop a spectrum of pathologies including pneumonia, acute respiratory distress syndrome, resp
Externí odkaz:
https://doaj.org/article/66776701468747d797b7a165327f7867