RC1339/APRc from Rickettsia conorii is a novel aspartic protease with properties of retropepsin-like enzymes.

Autor: Rui Cruz, Pitter Huesgen, Sean P Riley, Alexander Wlodawer, Carlos Faro, Christopher M Overall, Juan J Martinez, Isaura Simões

Publikováno v: PLoS Pathogens, Vol 10, Iss 8, p e1004324 (2014)

Members of the species Rickettsia are obligate intracellular, gram-negative, arthropod-borne pathogens of humans and other mammals. The life-threatening character of diseases caused by many Rickettsia species and the lack of reliable protective vacci

Externí odkaz: https://doaj.org/article/105628fee5024d54a96e868ae1aab42a

Cardosin A endocytosis mediated by integrin leads to lysosome leakage and apoptosis of epithelial cells

Autor: Carlos Faro, Pedro Castanheira, Hao Wu, Jordan Tang

Publikováno v: Proteins: Structure, Function, and Bioinformatics. 87:502-511

Cardosin A is an aspartic protease present in large amount in the pistils of cardoon flowers. This protease is known to contain an -Arg-Gly-Asp- (RGD) motif located on the molecular surface. In this study, we found that isolated recombinant cardosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410a358cc539cf809c4b9e29f8a56305
https://doi.org/10.1002/prot.25672

An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana

Autor: Rosário Faro, Pitter F. Huesgen, Alice Y. Cheung, Andreas Loos, Andre Luis Ramos Soares, Carlos Faro, Isaura Simões, Stefan Niedermaier, Bruno Manadas

Publikováno v: The journal of experimental botany 70(7), 2157–2171 (2019). doi:10.1093/jxb/erz059

Few atypical aspartic proteases (APs) present in plants have been functionally studied to date despite having been implicated in developmental processes and stress responses. Here we characterize a novel atypical AP that we name Atypical Aspartic Pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04909acf5e2fa822cef7f37f1fe85a8d
https://pubmed.ncbi.nlm.nih.gov/30778561

The draft genome sequence of cork oak

Autor: Carlos Faro, Leandra Rodrigues, Isabel Carrasquinho, Nelson J. M. Saibo, Conceição Egas, Maria Carolina Varela, Filomena Nóbrega, A. M. Ramos, Cândido Pinto Ricardo, M. Margarida Oliveira, Tiago Capote, Sónia Gonçalves, Joana Guimarães, Célia Miguel, Fernanda Simões, José Manuel Matos, Isabel A. Abreu, Pedro M. Barros, Inês Chaves, Diogo Mendonça, Ana Usié, Pedro Barbosa

Publikováno v: Scientific Data
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Cork oak (Quercus suber) is native to southwest Europe and northwest Africa where it plays a crucial environmental and economical role. To tackle the cork oak production and industrial challenges, advanced research is imperative but dependent on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6c48b268199c959e1650e77016450a

Functional and structural characterization of synthetic cardosin B-derived rennet

Autor: Carla Malaquias Almeida, Daniel Bur, Pedro Pereira, Bruno Manadas, Ana C. Figueiredo, Liliana Antunes, Rui Cruz, Carlos Faro, José A. Manso, Isaura Simões

Publikováno v: Applied microbiology and biotechnology. 101(18)

The potential of using a synthetic cardosin-based rennet in cheese manufacturing was recently demonstrated with the development and optimization of production of a recombinant form of cardosin B in Kluyveromyces lactis. With the goal of providing a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156ab0a5729ff5f55eca9fd45357f8a3
https://pubmed.ncbi.nlm.nih.gov/28770303