Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Carlos F Lagos"'
Autor:
Denis Houzelstein, Caroline Eozenou, Carlos F. Lagos, Maëva Elzaiat, Joelle Bignon-Topalovic, Inma Gonzalez, Vincent Laville, Laurène Schlick, Somboon Wankanit, Prochi Madon, Jyotsna Kirtane, Arundhati Athalye, Federica Buonocore, Stéphanie Bigou, Gerard S. Conway, Delphine Bohl, John C. Achermann, Anu Bashamboo, Ken McElreavey
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The Y-linked SRY gene initiates mammalian testis-determination. However, how the expression of SRY is regulated remains elusive. Here, we demonstrate that a conserved steroidogenic factor-1 (SF-1)/NR5A1 binding enhancer is required for appro
Externí odkaz:
https://doaj.org/article/4d468f3ebfe74e169182e3c50aa5412e
Autor:
Víctor A Cortés, Susan V Smalley, Denisse Goldenberg, Carlos F Lagos, María I Hodgson, José L Santos
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87173 (2014)
Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by extreme reduction of white adipose tissue (WAT) mass. CGL type 1 is the most frequent form and is caused by mutations in AGPAT2. Genetic and clinical s
Externí odkaz:
https://doaj.org/article/835a1b893c3c4e508357da8867ee5eec
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/c231c7709baa436eb13d7b888f0d9842
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59695 (2013)
Cocaine and Amphetamine Regulated Transcript (CART) peptides are anorexigenic neuropeptides. The L34F mutation in human CART peptide precursor (proCART) has been linked to obesity (Yanik et al. Endocrinology 147: 39, 2006). Decrease in CART peptide l
Externí odkaz:
https://doaj.org/article/b971e2fe16254055a5ddc9741e277de0
Pathogenic variants in the human m6A reader YTHDC2 are associated with primary ovarian insufficiency
Autor:
Sinéad M. McGlacken-Byrne, Ignacio Del Valle, Polona Le Quesne Stabej, Laura Bellutti, Luz Garcia-Alonso, Louise A. Ocaka, Miho Ishida, Jenifer P. Suntharalingham, Andrey Gagunashvili, Olumide K. Ogunbiyi, Talisa Mistry, Federica Buonocore, GOSgene, Berta Crespo, Nadjeda Moreno, Paola Niola, Tony Brooks, Caroline E. Brain, Mehul T. Dattani, Daniel Kelberman, Roser Vento-Tormo, Carlos F. Lagos, Gabriel Livera, Gerard S. Conway, John C. Achermann
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Primary ovarian insufficiency (POI) affects 1% of women and carries significant medical and psychosocial sequelae. Approximately 10% of POI has a defined genetic cause, with most implicated genes relating to biological processes involved in early fet
Externí odkaz:
https://doaj.org/article/8de8a399e8464d42b747b0aa3003ebbc
Autor:
Loreto Arrieta-Rodríguez, Daniela Espinoza-Rosales, Gonzalo Vera, Young Hwa Cho, David Cabezas, David Vásquez-Velásquez, Jaime Mella-Raipán, Carlos F. Lagos, Gonzalo Recabarren-Gajardo
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 528 (2021)
A new series of twenty-two C-5 substituted N-arylsulfonylindoles was prepared with the aim of exploring the influence of C-5 substitution on 5-HT6 receptor affinity. Eleven compounds showed moderate to high affinity at the receptor (Ki = 58–403 nM)
Externí odkaz:
https://doaj.org/article/1ab2e19e8e9c45508fb70a1c5c597cd3
Autor:
Andrea Vecchiola, Cristóbal A. Fuentes, Cristian A. Carvajal, Carmen Campino, Fidel Allende, Alejandra Tapia-Castillo, Carlos F. Lagos, Carlos E. Fardella
Publikováno v:
Revista médica de Chile. 149:1539-1543
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad5b09d1218c68351432eebae9686c92
https://doi.org/10.4067/s0034-98872021001101539
https://doi.org/10.4067/s0034-98872021001101539
Autor:
Anni Guo, Huiqi Zhang, Huanhuan Li, Arthur Chiu, Claudia García-Rodríguez, Carlos F. Lagos, Juan C. Sáez, Chunyue Geoffrey Lau
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(45)
Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy, yet approximately one-third of patients are refractory to current anticonvulsive drugs, which target neurons and synapses. Astrocytic and microglial dysfunction is commonly fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113a7ff374fc2c7279653f5ef2f22825
https://pubmed.ncbi.nlm.nih.gov/36322757
https://pubmed.ncbi.nlm.nih.gov/36322757
Publikováno v:
Transportation Science. 54:998-1015
The occurrence of unexpected aircraft maintenance tasks can produce expensive changes in an airline’s operation. When it comes to critical tasks, it might even cancel programmed flights. Despite this, the challenge of scheduling aircraft maintenanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d659a11cbd86efeb12767644e6f7875
https://doi.org/10.1287/trsc.2020.0984
https://doi.org/10.1287/trsc.2020.0984
Autor:
Luis A. Cea, Carlos F. Lagos, Daniel F. Escobar, Rosalba Escamilla, Carlos Puebla, Juan C. Sáez, Hugo Gaete, Esteban Barnafi, Paola Fernández, María Francisca Matus, Cristian Vilos, Bruno A. Cisterna, Aníbal A. Vargas, Christopher Cardozo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased plasma membrane permeability, reduced resting membrane potential and accelerated protein catabolism. The factors that induce th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68677d62d43cb9f0269dcbba41739ae0
http://link.springer.com/article/10.1038/s41467-019-14063-8
http://link.springer.com/article/10.1038/s41467-019-14063-8