Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Carlos F Lagos"'
Autor:
Denis Houzelstein, Caroline Eozenou, Carlos F. Lagos, Maëva Elzaiat, Joelle Bignon-Topalovic, Inma Gonzalez, Vincent Laville, Laurène Schlick, Somboon Wankanit, Prochi Madon, Jyotsna Kirtane, Arundhati Athalye, Federica Buonocore, Stéphanie Bigou, Gerard S. Conway, Delphine Bohl, John C. Achermann, Anu Bashamboo, Ken McElreavey
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The Y-linked SRY gene initiates mammalian testis-determination. However, how the expression of SRY is regulated remains elusive. Here, we demonstrate that a conserved steroidogenic factor-1 (SF-1)/NR5A1 binding enhancer is required for appro
Externí odkaz:
https://doaj.org/article/4d468f3ebfe74e169182e3c50aa5412e
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/c231c7709baa436eb13d7b888f0d9842
Autor:
Nitin Bharat Charbe, Carlos F. Lagos, Cristian Andrés Vilos Ortiz, Murtaza Tambuwala, Sushesh Srivatsa Palakurthi, Flavia C. Zacconi
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113428- (2022)
Ligand-based targeting of the receptors that are overexpressed explicitly on cancer cells represents an effective drug delivery approach to enhance the chemotherapeutic efficacy. Proprotein convertase subtilisin/kexin type 9 (PCSK9) which is a serine
Externí odkaz:
https://doaj.org/article/0ae72f54e64e447f8145db44c7ce1d5e
Pathogenic variants in the human m6A reader YTHDC2 are associated with primary ovarian insufficiency
Autor:
Sinéad M. McGlacken-Byrne, Ignacio Del Valle, Polona Le Quesne Stabej, Laura Bellutti, Luz Garcia-Alonso, Louise A. Ocaka, Miho Ishida, Jenifer P. Suntharalingham, Andrey Gagunashvili, Olumide K. Ogunbiyi, Talisa Mistry, Federica Buonocore, GOSgene, Berta Crespo, Nadjeda Moreno, Paola Niola, Tony Brooks, Caroline E. Brain, Mehul T. Dattani, Daniel Kelberman, Roser Vento-Tormo, Carlos F. Lagos, Gabriel Livera, Gerard S. Conway, John C. Achermann
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Primary ovarian insufficiency (POI) affects 1% of women and carries significant medical and psychosocial sequelae. Approximately 10% of POI has a defined genetic cause, with most implicated genes relating to biological processes involved in early fet
Externí odkaz:
https://doaj.org/article/8de8a399e8464d42b747b0aa3003ebbc
Autor:
Bruno A. Cisterna, Aníbal A. Vargas, Carlos Puebla, Paola Fernández, Rosalba Escamilla, Carlos F. Lagos, María F. Matus, Cristian Vilos, Luis A. Cea, Esteban Barnafi, Hugo Gaete, Daniel F. Escobar, Christopher P. Cardozo, Juan C. Sáez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Denervation of muscle fibres induces muscle atrophy, via mechanisms that remain unclear. Here, the authors show that binding of acetylcoline to its receptor at the neuromuscular junction represses the expression of connexins 43 and 45, which promote
Externí odkaz:
https://doaj.org/article/a63161896eea490ebe56ede16c508aaf
Autor:
Hugo E. Tobar, Luis R. Cataldo, Trinidad González, Ricardo Rodríguez, Valentina Serrano, Antonio Arteaga, Ana Álvarez-Mercado, Carlos F. Lagos, Lucas Vicuña, José P. Miranda, Ana Pereira, Carolina Bravo, Concepción M. Aguilera, Susana Eyheramendy, Ricardo Uauy, Álvaro Martínez, Ángel Gil, Omar Francone, Attilio Rigotti, José L. Santos
Publikováno v:
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-10 (2019)
Abstract Background Lecithin-cholesterol acyltransferase (LCAT) is a plasma enzyme that esterifies cholesterol in high- and low-density lipoproteins (HDL and LDL). Mutations in LCAT gene causes familial LCAT deficiency, which is characterized by very
Externí odkaz:
https://doaj.org/article/08593db270244f0995b5209d4d00e7b3
Autor:
Andrea Vecchiola, Cristóbal A. Fuentes, Isidora Solar, Carlos F. Lagos, Maria Cecilia Opazo, Natalia Muñoz-Durango, Claudia A. Riedel, Gareth I. Owen, Alexis M. Kalergis, Carlos E. Fardella
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Introduction: Mineralocorticoid receptor (MR) activation within adipose tissue, triggers inflammation and metabolic syndrome development. The pharmacological blockade of MR provides beneficial effects for adipose tissue. Our study evaluates the impac
Externí odkaz:
https://doaj.org/article/ff0efca0491648a4a82847b55c577659
Autor:
Loreto Arrieta-Rodríguez, Daniela Espinoza-Rosales, Gonzalo Vera, Young Hwa Cho, David Cabezas, David Vásquez-Velásquez, Jaime Mella-Raipán, Carlos F. Lagos, Gonzalo Recabarren-Gajardo
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 528 (2021)
A new series of twenty-two C-5 substituted N-arylsulfonylindoles was prepared with the aim of exploring the influence of C-5 substitution on 5-HT6 receptor affinity. Eleven compounds showed moderate to high affinity at the receptor (Ki = 58–403 nM)
Externí odkaz:
https://doaj.org/article/1ab2e19e8e9c45508fb70a1c5c597cd3
Autor:
Fabián Santana-Romo, Carlos F. Lagos, Yorley Duarte, Francisco Castillo, Yanina Moglie, Miguel A. Maestro, Nitin Charbe, Flavia C. Zacconi
Publikováno v:
Molecules, Vol 25, Iss 3, p 491 (2020)
The coagulation cascade is the process of the conversion of soluble fibrinogen to insoluble fibrin that terminates in production of a clot. Factor Xa (FXa) is a serine protease involved in the blood coagulation cascade. Moreover, FXa plays a vital ro
Externí odkaz:
https://doaj.org/article/c44b7840d55a4af6b00e7dbf344236fa
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
The corticotropin-releasing factor (CRF) system is a key mediator of the stress response and addictive behavior. The CRF system includes four peptides: The CRF system includes four peptides: CRF, urocortins I–III, CRF binding protein (CRF-BP) that
Externí odkaz:
https://doaj.org/article/995c517ec61a42a6b0aa074acdf77830