Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Carlos F Ibanez"'
Autor:
Zhi Lin, Jason Y Tann, Eddy TH Goh, Claire Kelly, Kim Buay Lim, Jian Fang Gao, Carlos F Ibanez
Publikováno v:
eLife, Vol 4 (2015)
Death domains (DDs) mediate assembly of oligomeric complexes for activation of downstream signaling pathways through incompletely understood mechanisms. Here we report structures of complexes formed by the DD of p75 neurotrophin receptor (p75NTR) wit
Externí odkaz:
https://doaj.org/article/b1f4b79080bc49a0884e4088e703e833
Autor:
Tingqing Guo, Patricia Marmol, Annalena Moliner, Marie Björnholm, Chao Zhang, Kevan M Shokat, Carlos F Ibanez
Publikováno v:
eLife, Vol 3 (2014)
Obesity is associated with blunted β-adrenoreceptor (β-AR)-mediated lipolysis and lipid oxidation in adipose tissue, but the mechanisms linking nutrient overload to catecholamine resistance are poorly understood. We report that targeted disruption
Externí odkaz:
https://doaj.org/article/909ce91d0b794f94bf6e2419ec4a5b1a
Publikováno v:
eLife, Vol 13 (2024)
Perirenal adipose tissue (PRAT) is a unique visceral depot that contains a mixture of brown and white adipocytes. The origin and plasticity of such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic li
Externí odkaz:
https://doaj.org/article/31f30b9ec13d4d74b221cd05436b8dac
Autor:
Diana Fernández-Suárez, Favio A Krapacher, Katarzyna Pietrajtis, Annika Andersson, Lilian Kisiswa, Alvaro Carrier-Ruiz, Marco A Diana, Carlos F Ibáñez
Publikováno v:
PLoS Biology, Vol 19, Iss 11, p e3001350 (2021)
The medial habenula (mHb) is an understudied small brain nucleus linking forebrain and midbrain structures controlling anxiety and fear behaviors. The mechanisms that maintain the structural and functional integrity of mHb neurons and their synapses
Externí odkaz:
https://doaj.org/article/a81eeea4f70a466bb47cb01ec936e466
Publikováno v:
eLife, Vol 9 (2020)
Adaptation to nutrient availability is crucial for survival. Upon nutritional stress, such as during prolonged fasting or cold exposure, organisms need to balance the feeding of tissues and the maintenance of body temperature. The mechanisms that reg
Externí odkaz:
https://doaj.org/article/591e10b7c7154552a4c38052534bff74
Publikováno v:
eLife, Vol 5 (2016)
Neocortical GABAergic interneuron migration and thalamo-cortical axon (TCA) pathfinding follow similar trajectories and timing, suggesting they may be interdependent. The mechanisms that regulate the radial dispersion of neocortical interneurons are
Externí odkaz:
https://doaj.org/article/8e6fbf5035a34567a6f89f0fc7604fd3