Výsledky vyhledávání - "Carlos F De La Cruz-Herrera"

Akademický článek

Epstein-Barr Virus BGLF2 commandeers RISC to interfere with cellular miRNA function.

Autor: Ashley M Campbell, Carlos F De La Cruz-Herrera, Edyta Marcon, Jack Greenblatt, Lori Frappier

Publikováno v: PLoS Pathogens, Vol 18, Iss 1, p e1010235 (2022)

The Epstein-Barr virus (EBV) BGLF2 protein is a tegument protein with multiple effects on the cellular environment, including induction of SUMOylation of cellular proteins. Using affinity-purification coupled to mass-spectrometry, we identified the m

Externí odkaz: https://doaj.org/article/b3b53002be3b443c821c04be51800811

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Akademický článek

A genome-wide screen of Epstein-Barr virus proteins that modulate host SUMOylation identifies a SUMO E3 ligase conserved in herpesviruses.

Autor: Carlos F De La Cruz-Herrera, Kathy Shire, Umama Z Siddiqi, Lori Frappier

Publikováno v: PLoS Pathogens, Vol 14, Iss 7, p e1007176 (2018)

Many cellular processes pertinent for viral infection are regulated by the addition of small ubiquitin-like modifiers (SUMO) to key regulatory proteins, making SUMOylation an important mechanism by which viruses can commandeer cellular pathways. Epst

Externí odkaz: https://doaj.org/article/ac67598a869947b5aaddc437f4e57c09

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SUMOylation modulates the stability and function of PI3K-p110β

Autor: Maite Baz-Martínez, Emilio Lecona, Mariano Esteban, Ahmed El Motiam, Yanis Hichem Bouzaher, Anxo Vidal, Manuel S. Rodriguez, Carlos F. de la Cruz-Herrera, Carmen Rivas, Rocío Seoane, Manuel Collado, Santiago Vidal

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78, pp.4053-4065. ⟨10.1007/s00018-021-03826-6⟩
Cellular and Molecular Life Sciences, 2021, 78, pp.4053-4065. ⟨10.1007/s00018-021-03826-6⟩

Class I PI3K are heterodimers composed of a p85 regulatory subunit and a p110 catalytic subunit involved in multiple cellular functions. Recently, the catalytic subunit p110β has emerged as a class I PI3K isoform playing a major role in tumorigenesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27ff17659e1f2a1cf96ba0400d33eff
http://hdl.handle.net/10261/269302

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Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function

Autor: Carmen Rivas, Rune Matthiesen, Sabela Da Silva-Álvarez, Manuel Collado, Ahmed El Motiam, Ana Sofia Carvalho, Hans Christian Beck, Carlos F. de la Cruz-Herrera, Maite Baz-Martínez, Anxo Vidal, Dimitris P. Xirodimas, Santiago Vidal, Rocío Seoane, Manuel S. Rodriguez

Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2019, ⟨10.1096/fj.201800341RR⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2018, ⟨10.1096/fj.201800341RR⟩
El Motiam, A, Vidal, S, de la Cruz-Herrera, C F, Da Silva-Álvarez, S, Baz-Martínez, M, Seoane, R, Vidal, A, Rodríguez, M S, Xirodimas, D P, Carvalho, A S, Beck, H C, Matthiesen, R, Collado, M & Rivas, C 2019, ' Interplay between SUMOylation and NEDDylation regulates RPL11 localization and function ', F A S E B Journal, vol. 33, no. 1, pp. 643-651 . https://doi.org/10.1096/fj.201800341RR
FASEB Journal, 2019, ⟨10.1096/fj.201800341RR⟩

The ribosomal protein L11 (RPL11) integrates different types of stress into a p53-mediated response. Here, we analyzed the impact of the ubiquitin-like protein SUMO on the RPL11-mouse double-minute 2 homolog-p53 signaling. We show that small ubiquiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d29259aa76e95ecfac8d6b58c1ff08
http://hdl.handle.net/10261/240641

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Phosphorylable tyrosine residue 162 in the double-stranded RNA-dependent kinase PKR modulates its interaction with SUMO

Autor: Maite Baz-Martínez, Carmen Rivas, Mariano Esteban, Santiago Vidal, Carlos F. de la Cruz-Herrera, Manuel S. Rodriguez, Ahmed El Motiam, Anxo Vidal, Manuel Collado

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)

Activated dsRNA-dependent serine/threonine kinase PKR phosphorylates the alpha subunit of eukaryotic initiation factor 2 (eIF2α), resulting in a shut-off of general translation, induction of apoptosis, and inhibition of virus replication. PKR can be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb280d6b5e31ff646387536e0a61a66
https://doi.org/10.1038/s41598-017-12777-7

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Regulation of Ebola virus VP40 matrix protein by SUMO

Autor: Ahmed El Motiam, Paula Ruibal, Manuel S. Rodriguez, Maite Baz-Martínez, Carmen San Martín, Carmen Rivas, Manuel Collado, César Muñoz-Fontela, Gabriela N. Condezo, Valérie Lang, Carlos F. de la Cruz-Herrera

Publikováno v: Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Scientific Reports

The matrix protein of Ebola virus (EBOV) VP40 regulates viral budding, nucleocapsid recruitment, virus structure and stability, viral genome replication and transcription, and has an intrinsic ability to form virus-like particles. The elucidation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4e4546f5d514f3a3a8a568b2bde7bf
https://hdl.handle.net/10347/15973

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A genome-wide screen of Epstein-Barr virus proteins that modulate host SUMOylation identifies a SUMO E3 ligase conserved in herpesviruses

Autor: Kathy Shire, Lori Frappier, Umama Z. Siddiqi, Carlos F. de la Cruz-Herrera

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 7, p e1007176 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae151c25c2fe405155fc1f83b9fb14b
https://doi.org/10.1371/journal.ppat.1007176

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Activation of the double-stranded RNA-dependent protein kinase PKR by small ubiquitin-like modifier (SUMO)

Autor: S. Gutiérrez, María Ángel García, Michela Campagna, Anxo Vidal, Carlos F. de la Cruz-Herrera, Valérie Lang, Mariano Esteban, Manuel S. Rodriguez, Laura Marcos-Villar, Maite Baz-Martínez, Carmen Rivas

Publikováno v: RUNA. Repositorio da Consellería de Sanidade e Sergas
Servizo Galego de Saúde (SERGAS)

Journal Article; Research Support, Non-U.S. Gov't; The dsRNA-dependent kinase PKR is an interferon-inducible protein with ability to phosphorylate the α subunit of the eukaryotic initiation factor (eIF)-2 complex, resulting in a shut-off of general

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe4702a71da096ed84320c1037a4e77
http://hdl.handle.net/20.500.11940/4558

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Analysis of SUMOylated proteins using SUMO-traps

Autor: Carlos F. de la Cruz-Herrera, Carmen Rivas, Elisa Da Silva-Ferrada, Valérie Lang, Itziar Martín-Ruiz, Seth J. Goldenberg, Patrick England, Wendy Xolalpa, Manuel S. Rodriguez, Arkaitz Carracedo, Fabienne Aillet, Fernando Lopitz-Otsoa

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
Scientific Reports
Scientific Reports, 2013, 3 (1), pp.1690. ⟨10.1038/srep01690⟩

6 p. [+ 7 p. Supplementary Information] SUMO-modified proteins are recognized by SUMO interacting motifs (SIMs), thus triggering diverse cellular responses. Here SIMs were used to develop SUMO-traps to capture endogenous SUMOylated proteins. Our resu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64bb71087509ab450d135061f8048e5a
http://hdl.handle.net/10810/11390

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